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Research

31,380 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 126–150 of 497 studies with an author at Johns Hopkins University (US) · free to read (page 6 of 20) · 31,380 in the whole library · How the 0–100 score works

Download bibliography of these 497 studies, in this order: BibTeX (.bib) · RIS (.ris)

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Authors

Names as each record prints them; the same person can appear under two spellings.

Other institutions

From OpenAlex; 16,851 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

Continuity of Care and Health Care Utilization in Older Adults With Dementia in Fee-for-Service Medicare

✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA internal medicine 2016-09-01

Beneficiaries with dementia who had lower levels of continuity of care were younger, had a higher income, and had more comorbid medical conditions. 3 key findings →

Design: retrospective cohort Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

The Association of Late-Life Diabetes Status and Hyperglycemia With Incident Mild Cognitive Impairment and Dementia: The ARIC Study

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Diabetes care 2019-05-21

Diabetes status, poor glycemic control, and longer diabetes duration were associated with worse cognitive outcomes over a median follow-up of 5 years. 4 key findings →

Participants: 5,099 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Association Between Acute Myocardial Infarction and Cognition

✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA neurology 2023-07-01

This cohort study using pooled data from 6 cohort studies found that incident MI was not associated with a decrease in global cognition, memory, or executive function at the time of the event compared with no MI but was associated with faster declines in global cognition, memory, and executive function over time. 5 key findings →

Design: cohort study Participants: 30 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Neuron 2011-09-21

The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases. 2 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment

✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA network open 2024-10-01

It remains unclear which risk factors accelerate brain atrophy along with a progression from normal cognition to mild cognitive impairment (MCI). 4 key findings →

Design: cohort study Participants: 185 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Archives of general psychiatry 2007-12-01

From a longitudinal study of normal (Clinical Dementia Rating [CDR] = 0; n = 77) and mildly impaired (CDR = 0.5; n = 167) participants with 5 or more annual clinical assessments, baseline level of cognitive impairment in daily life was graded using CDR sum of boxes (CDR-SB) and level of cognitive performance impairment was graded using neuropsychological test scores. 4 key findings →

Design: longitudinal study Participants: 77 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Impact of differential attrition on the association of education with cognitive change over 20 years of follow-up: the ARIC neurocognitive study

✓ Peer-reviewed alzhub usefulness score 63 out of 100. American journal of epidemiology 2014-03-13

Studies of long-term cognitive change should account for the potential effects of education on the outcome, since some studies have demonstrated an association of education with dementia risk. 4 key findings →

Design: cohort study Participants: 14,020 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Association of Intracranial Atherosclerotic Disease With Brain β-Amyloid Deposition: Secondary Analysis of the ARIC Study

✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA neurology 2020-03-01

Intracranial atherosclerotic disease (ICAD) is an important cause of stroke and has also been recently identified as an important risk factor for all-cause dementia, but the mechanism of its association with cognitive performance is not fully understood. 4 key findings →

Design: cohort study Participants: 346 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Nature aging 2021-05-14

The plasma proteomic changes that precede the onset of dementia could yield insights into disease biology and highlight new biomarkers and avenues for intervention. 4 key findings →

Participants: 4,110 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Food Insecurity and Cognitive Trajectories in Community-Dwelling Medicare Beneficiaries 65 Years and Older

✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA Network Open 2023-03-24

Of 3037 participants, a weighted 57.8% (raw count, 1345) were younger than 75 years, 56.2% (raw count, 1777) were women, and most (84.9% [raw count, 2268]) were White. 5 key findings →

Design: cohort study Participants: 3,037 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Population Attributable Fraction of Incident Dementia Associated With Hearing Loss

✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA Otolaryngology–Head & Neck Surgery 2025-04-17

Among 2946 participants (mean [SD] age, 74.9 [4.6] years; 1751 [59.4] female; 637 Black [21.6%] and 2309 White [78.4%] individuals), 1947 participants (66.1%) had audiometric hearing loss, and 1097 (37.2%) had self-reported hearing loss. 5 key findings →

Design: cohort study Participants: 2,946 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Machine learning reveals distinct neuroanatomical signatures of cardiovascular and metabolic diseases in cognitively unimpaired individuals

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Nature Communications 2025-03-19

Comorbid cardiovascular and metabolic risk factors (CVM) differentially impact brain structure and increase dementia risk, but their specific magnetic resonance imaging signatures (MRI) remain poorly characterized. 1 key finding →

Design: cohort study Participants: 37,096 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Sex differences in the clinical manifestation of autosomal dominant frontotemporal dementia

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Alzheimer s & Dementia 2025-04-01

While sex differences were not apparent at asymptomatic stages, females showed more rapid declines across all outcomes in symptomatic stages compared to males. 5 key findings →

Design: longitudinal study Participants: 337 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts

✓ Peer-reviewed alzhub usefulness score 62 out of 100. PloS one 2019-02-15

Differences between users and non-users of insulin, metformin and sulfonylurea were assessed in each cohort for cognitive and brain MRI measures using linear regression models, and cognitive decline and dementia/AD risk using mixed effect models and Cox regression analyses, respectively. 4 key findings →

Participants: 3,590 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline

✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2018-07-25

We analyzed data from 11,709 participants without a history of coronary heart disease or stroke who attended the baseline examination (1987-1989) of the prospective Atherosclerosis Risk in Communities (ARIC) study. 4 key findings →

Participants: 11,709 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Relationship of Cigarette Smoking and Time of Quitting with Incident Dementia and Cognitive Decline

✓ Peer-reviewed alzhub usefulness score 62 out of 100. Journal of the American Geriatrics Society 2019-11-01

Understanding how dementia risk is impacted by timing of smoking cessation has public health implications for prevention efforts. 4 key findings →

Design: cohort study Participants: 1,347 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72

✓ Peer-reviewed alzhub usefulness score 62 out of 100. Brain : a journal of neurology 2012-03-01

Intronic expansion of the GGGGCC hexanucleotide repeat within the C9ORF72 gene causes frontotemporal dementia and amyotrophic lateral sclerosis/motor neuron disease in both familial and sporadic cases. 4 key findings →

Participants: 361 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

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Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled.

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomized / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multicenter collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 31,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 31,380 records, built mostly from automated pulls of Europe PMC (65.6% of the library) and OpenAlex (16.2%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,048 records (3.3% of the library) are not peer-reviewed — 973 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed    Where this research is being discussed: events