Obesity promotes carcinogenesis through interlocking metabolic, inflammatory, immune, and hormonal pathways. 2 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Research
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Family history of hypertension may reflect genetic and lifestyle factors. 3 key findings →
Design: cohort study Participants: 9,001 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Over 7,430,253 person-years of follow-up, 11,345 dementia cases occurred (10,863 AD and 2,159 VaD). 5 key findings →
Design: cohort study Participants: 296,001 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
In both the mortality and readmission cohorts we found significant associations with each pollutant. 5 key findings →
Design: retrospective cohort Participants: 118 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
58/100
Hearing impairment is implicated as a risk factor for the incidence of all-cause dementia. 3 key findings →
Design: cohort study Participants: 158,686 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
In the UK Biobank cohort (N = 166,916), MIND diet demonstrated the broadest neuroprotective effects. 5 key findings →
Design: prospective cohort Participants: 166,916 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Research evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. 2 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Data from a total of 458 patients were collected. 4 key findings →
Design: cross-sectional Participants: 458 Evidence: low
Full summary, score breakdown and related studies → Original source
Apolipoprotein E epsilon4 led to increased risk of AD among white subjects but not black subjects. 5 key findings →
Participants: 6,158 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Mean IGF-1 levels were 144 ± 60 μg/L in generation 1 and 114 ± 37 μg/L in generation 2. 3 key findings →
Participants: 789 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
We systematically compared structural imaging patterns of advanced brain aging (ABA) in the general-population, herein defined as significant deviation from typical BA to those found in Alzheimer disease (AD). 5 key findings →
Participants: 2,705 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
The data do not support an association between serum total cholesterol or high density lipoprotein in late life and subsequent risk of dementia or Alzheimer disease (AD). 5 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
The evidence of a preventive treatment effect aimed at vascular risk factors on cognitive decline and dementia in later life is scarce and mostly based on secondary outcome parameters. 4 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Obesity at midlife is associated with an increased risk of dementia and AD later in life. 3 key findings →
Participants: 1,449 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Despite mortality due to communicable diseases, poverty, and human conflicts, dementia incidence is destined to increase in the developing world in tandem with the ageing population. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The Alzheimer type of dementia and stroke are known to increase at comparable rates with age. 2 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
In recent years, accumulating evidence has suggested that vascular risk factors contribute to Alzheimer disease (AD). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The late-life dementia risk index accurately stratified older adults into those with low, moderate, and high risk of developing dementia. 2 key findings →
Participants: 480 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Forty-three patients with PD were demented at follow-up evaluation, equivalent to an incidence rate of 95.3 per 1,000 person-years (95% CI, 68.2 to 122.0). 2 key findings →
Participants: 171 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Over an average follow-up of 4 y, dementia developed in 112 subjects, including 70 who received a diagnosis of AD. 3 key findings →
Design: cross-sectional Participants: 816 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
This risk was not mediated by smaller hippocampal or amygdalar volumes. 2 key findings →
Participants: 503 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Level of cognitively stimulating activity in old age is related to risk of developing dementia. 4 key findings →
Participants: 90 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Higher cardiovascular risk burden may predict decline in episodic memory, working memory, and perceptual speed and is associated with neurodegeneration and vascular lesions in the brain. 4 key findings →
Participants: 378 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Despite lower dementia prevalence, Black participants with dementia had more dementia risk factors, as well as greater cognitive impairment and neuropsychiatric symptom severity than White participants. 1 key finding →
Participants: 5,700 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Sensory impairments were common: 28% had visual impairment, 35% had hearing loss, 22% had poor smell, 12% had touch insensitivity; 26% had more than two impairments, and 5.6% had more than three sensory impairments. 2 key findings →
Participants: 1,810 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
From across this tag
10 of the 3,281 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Effect of initiating an ARB- versus ACEI-based regimen on dementia risk, a target trial emulation of 2.5 million US Veterans
- Fluid Biomarkers of Cognitive Impairments Following Traumatic Brain Injury: A Systematic Review and Meta Analysis
- Multisystem failure, tipping points, and risk of Alzheimer's disease
- Dementia in Sub-Saharan Africa: Risk factors, public perception, and management approaches
- Incidence and Prevalence of Alzheimer’s Disease in Medicare Beneficiaries
- The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us
- Association of Low-Level Ozone with Cognitive Decline in Older Adults
- Metabolic syndrome, hypertension, and nervous system injury: Epidemiological correlates
- Cognitive change is more positively associated with an active lifestyle than with training interventions in older adults at risk of dementia: a controlled interventional clinical trial
- Association of Body Mass Index in Late Life, and Change from Midlife to Late Life, With Incident Dementia in the ARIC Study Participants
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →