27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
The study determined an adequate sample size (KMO = 0.67), with sufficient item correlations for factor analysis (χ2 = 449.74; p < 0.001). 5 key findings →
Participants: 310 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
BackgroundEvidence on the effects of caregiver-assisted combined exercise and cognitive interventions for persons with dementia (PwD) is inconsistent. 2 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Higher MIND diet scores during the follow-up were associated with fewer reactive microglia (i.e., less neuroinflammation) in the hippocampus when controlled for age at death, sex, education, calories, and AD pathology (β=-0.035, SE=0.02, p = 0.045), but not with total microglia (β=-4.88, SE=3.08, p = 0.114). 5 key findings →
Participants: 237 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Cognitive training, whether combined with active or sham tDCS, led to significantly increased fractional anisotropy averaged across all brain regions, indicating an overall improvement in white matter integrity. 5 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Considerable research has linked many risk factors to Alzheimer's Disease and Related Dementias (ADRD). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
In recent years, the idea that sleep is critical for cognitive processing has gained strength. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The APOE gene alleles modify human aging and the response to the diet at many levels with diverse pleotropic effects from gut to brain. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A linear mixed effects model revealed a significant interaction in the right parietal lobe: the MCI group showed increased connectivity while the healthy elders showed decreased connectivity. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Homocysteine (Hcy), a sulfur-containing nonproteinogenic amino acid, is generated as a metabolic intermediate. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Vascular cognitive impairment (VCI) is the second most common type of dementia after Alzheimer's disease (AD). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The collected articles were categorized into studies related to 6 systems or disease types: motor system (17 articles), metabolic system (110 articles), cardiocerebral vascular system (171 articles), nervous system (71 articles), urinary system (2 articles), and cancer (21 articles). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The prevalence of dementia has substantially increased worldwide. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
As patients lose cognitive function, they lose autonomy and increasingly use fiscal, social, and medical resources. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The societal value of strategies that delay the onset and progression of dementia cannot be overstated. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Engaging in targeted exercise interventions is a promising, non-pharmacological strategy to mitigate the deleterious effects of aging and disease on brain health. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Physical activity and exercise have become a central component of medical management of chronic illness, particular for the elderly who suffer from neurodegenerative disorders that impair their cognition and mobility. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A significant body of evidence supports the protective role of exercise training (ET) in cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer disease or even in the recovery of spinal cord injury. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The number of adults with Alzheimer's disease (AD) or related dementia is expected to increase exponentially. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Present demographic changes demonstrate that the number of elderly people is growing at a frenetic pace. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. 1 key finding →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
Dementias, and Alzheimer's disease (AD) in particular, will increasingly become a public health issue. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Dementia is increasing in Australia in line with population ageing and is expected to peak by mid-century. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Increased age is associated with normative declines in both sleep and cognitive functioning. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The endogenous circadian rhythms are one of the cardinal processes that control sleep. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
10 of the 1,856 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →