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Home › Research › Topics › tdp-43

tdp-43

1,157 studies tagged tdp-43, dated 1986-01-01 to 2026-09-25. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia? 2026-09-25
  2. Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration 2026-09-20
  3. Laromestrocel preserves brain volume and cognitive function in Alzheimers disease by inhibiting neuroinflammation 2026-09-17

Studies

1,157 studies carry this tag.

Date range

1986 to 2026

Top journals

  • The Journal of biological chemistry 109
  • The Journal of neuroscience : the official journal of the Society for Neuroscience 42
  • Proceedings of the National Academy of Sciences of the United States of America 39
  • Neuron 28
  • Nature 23

363 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Brain and behavior 2020-01-30 Biomarkers

    Prenatal exposure to low doses of LPS caused AD-related features including behavioral and neuropathological changes from midlife to senectitude.

  2. ATP13A2 deficiency disrupts lysosomal polyamine export

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature 2020-01-29 Brain tissue and pathology

    ATP13A2 (PARK9) is a late endolysosomal transporter that is genetically implicated in a spectrum of neurodegenerative disorders, including Kufor-Rakeb syndrome-a parkinsonism with dementia 1 -and early-onset Parkinson's disease 2 .

  3. Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in pharmacology 2020-01-17 TREM2 and immune genetics

    Quercetin is a polyphenol with multiple biological activities, and results of our preliminary study showed that it could shorten the immobility time of mice in the forced swimming test and tail suspending test.

  4. Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Journal of neurology, neurosurgery, and psychiatry 2020-01-14 Cognitive tests and assessment

    There are few validated fluid biomarkers in frontotemporal dementia (FTD).

  5. Differential role of triggering receptors expressed on myeloid cells 2 R47H in 3 neurodegenerative diseases based on a systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Medicine 2020-01-01 TREM2 and immune genetics

    The AD set included 23,092 cases and 30,920 controls, the ALS set included 7391 cases and 12,442 controls, and the PD set included 8498 patients and 9161 controls.

  6. Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Antioxidants (Basel, Switzerland) 2019-12-31 Prevention trials

    Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson's disease (PD), and seems to play a key role in their development and progression.

  7. Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuron 2019-12-30 Inflammation and the immune system

    Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB).

  8. Effect of fresh pomegranate juice on the level of melatonin, insulin, and fasting serum glucose in healthy individuals and people with impaired fasting glucose

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Food science & nutrition 2019-12-17 Treatments

    Pomegranate juice (PGJ) is rich in unique bioactive compounds that can be used in the management of various diseases/disorders such as cancer, heart disease, Alzheimer disease, hypertension, and diabetes.

  9. Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Acta neuropathologica communications 2019-12-16 Biomarkers

    Activated Caspase-6 (Casp6) is associated with age-dependent cognitive impairment and Alzheimer disease (AD).

  10. Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Aging cell 2019-12-04 TREM2 and immune genetics

    A promising new therapeutic target for the treatment of Alzheimer's disease (AD) is the circadian system.

  11. Thalamic nuclei in frontotemporal dementia: Mediodorsal nucleus involvement is universal but pulvinar atrophy is unique to C9orf72

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Human brain mapping 2019-11-07 Disease mechanisms

    Thalamic atrophy is a common feature across all forms of FTD but little is known about specific nuclei involvement.

  12. ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Arteriosclerosis, thrombosis, and vascular biology 2019-10-31 Genetics

    ApoE4 impairs pericyte-mediated basement membrane formation, potentially contributing to the cerebrovascular effects of apoE4.

  13. CRISPR/Cas13a-Powered Electrochemical Microfluidic Biosensor for Nucleic Acid Amplification-Free miRNA Diagnostics

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Advanced materials (Deerfield Beach, Fla.) 2019-10-30 Getting a diagnosis

    Noncoding small RNAs, such as microRNAs, are becoming the biomarkers of choice for multiple diseases in clinical diagnostics.

  14. Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Molecular immunology 2019-10-04 TREM2 and immune genetics

    Microglia mediate multiple facets of neuroinflammation, which plays a double-edged role in various brain diseases via distinct microglial phenotypes (deleterious M1 and neuroprotective M2).

  15. Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. JCI insight 2019-09-19 Prevention and risk

    Insulin resistance associates with increased risk for cognitive decline and dementia; however, the underpinning mechanisms for this increased risk remain to be fully defined.

  16. Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. JCI insight 2019-09-05 Long-term cohort studies

    With increased life expectancy worldwide, there is an urgent need for improving preventive measures that delay the development of age-related degenerative diseases.

  17. Fecal microbiota transplantation alleviated Alzheimer's disease-like pathogenesis in APP/PS1 transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Translational psychiatry 2019-08-05 Inflammation and the immune system

    Alzheimer's disease (AD) is the most common dementia in the elderly.

  18. Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. The EMBO journal 2019-07-30 Inflammation and the immune system

    Alzheimer's disease is the most prevalent type of dementia and is caused by the deposition of extracellular amyloid-beta and abnormal tau phosphorylation.

  19. Transcriptional regulation of homeostatic and disease-associated-microglial genes by IRF1, LXRβ, and CEBPα

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Glia 2019-07-13 TREM2 and immune genetics

    Microglia transform from homeostatic to disease-associated-microglia (DAM) profiles in neurodegeneration.

  20. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Neuron 2019-07-01 Brain tissue and pathology

    Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD).

  21. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Acta neuropathologica 2019-05-27 Long-term cohort studies

    The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD).

  22. C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature neuroscience 2019-05-13 Disease mechanisms

    The GGGGCC repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  23. Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neuron 2019-05-07 Lewy body dementia

    Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as frontotemporal dementia and Alzheimer's disease.

  24. Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cell reports 2019-05-01 TREM2 and immune genetics

    Microglia have important remodeling functions in neurodevelopment, aging, and disease, with evidence for molecular diversity.

  25. Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2019-04-29 TREM2 and immune genetics

    Cerebral amyloid angiopathy (CAA) results from amyloid-β deposition in the cerebrovasculature.

  26. Prolong treatment with Trans-ferulic acid mitigates bioenergetics loss and restores mitochondrial dynamics in streptozotocin-induced sporadic dementia of Alzheimer's type

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Neurotoxicology 2019-04-25 Biomarkers

    Alzheimer disease has been well associated with mitochondrial dysfunctions.

  27. Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Autophagy 2019-04-02 Biomarkers

    Imbalance in production and clearance of amyloid beta (Aβ) is the primary reason for its deposition in Alzheimer disease.

  28. The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Frontiers in neuroscience 2019-03-26 Tau biomarkers

    Crocus sativus L. natural compounds have been extensively used in traditional medicine for thousands of years.

  29. RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammation, Apoptosis and Memory Impairments by Modulating TLR4/NF-κB Signaling

    ⚠ Retracted — do not rely on it alzhub usefulness score 16 out of 100. Nutrients 2019-03-17 Biomarkers

    Glial activation and neuroinflammation play significant roles in apoptosis as well as in the development of cognitive and memory deficits.

  30. Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Redox biology 2019-03-09 Down syndrome and Alzheimer's

    Increasing evidences support the notion that the impairment of intracellular degradative machinery is responsible for the accumulation of oxidized/misfolded proteins that ultimately results in the deposition of protein aggregates.

  31. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neuron 2019-03-07 Lewy body dementia

    While cytoplasmic aggregation of TDP-43 is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia, how aggregates form and what drives its nuclear clearance have not been determined.

  32. The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Acta neuropathologica communications 2019-03-06 Disease mechanisms

    Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions.

  33. Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2019-03-05 TREM2 and immune genetics

    Microglia are the principal innate immune defense cells of the centeral nervous system (CNS) and the target of the human immunodeficiency virus type one (HIV-1).

  34. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Science translational medicine 2019-03-01 Disease mechanisms

    Tau inclusions are a shared feature of many neurodegenerative diseases, among them frontotemporal dementia caused by tau mutations.

  35. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neuron 2019-02-27 Lewy body dementia

    TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within degenerating regions of patient postmortem tissue.

  36. The role of liquid-liquid phase separation in aggregation of the TDP-43 low-complexity domain

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of biological chemistry 2019-02-27 Lewy body dementia

    Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with several neurodegenerative disorders, including ALS, frontotemporal dementia, chronic traumatic encephalopathy, and Alzheimer's disease.

  37. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2019-02-15 Clinical safety

    Our in vivo model of c9FTD/ALS is the first to robustly recapitulate hallmark features derived from both sense and antisense C9orf72 repeat-associated transcripts complete with neurodegeneration and behavioral impairments.

  38. Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Frontiers in molecular neuroscience 2019-02-14 Lewy body dementia

    TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism.

  39. PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Cell research 2019-02-06 Brain tissue and pathology

    Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  40. Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2019-01-30 Biomarkers

    It has been well documented that neurotrophins, including brain-derived neurotrophic factor (BDNF), are severely affected in Alzheimer's disease (AD), but their administration faces a myriad of technical challenges.

  41. PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2019-01-28 Disease mechanisms

    Alzheimer's disease (AD) is a heterogeneous disorder with multiple etiologies.

  42. Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Glia 2019-01-25 TREM2 and immune genetics

    Type I interferons (IFN-I) are the principal antiviral molecules of the innate immune system and can be made by most cell types, including central nervous system cells.

  43. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Nature neuroscience 2019-01-14 Lewy body dementia

    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43).

  44. Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Nature reviews. Neuroscience 2019-01-01 Inflammation and the immune system

    Apoptosis is crucial for the normal development of the nervous system, whereas neurons in the adult CNS are relatively resistant to this form of cell death.

  45. Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational psychiatry 2018-12-13 Disease mechanisms

    Mutations in the microtubule-associated protein tau (MAPT) gene cause autosomal dominant frontotemporal lobar degeneration with tau inclusions (FTLD-tau).

  46. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018-12-07 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells-2 (TREM2) is an innate immune receptor that promotes phagocytosis by myeloid cells such as microglia and macrophages.

  47. proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular brain 2018-11-14 Disease mechanisms

    Alzheimer disease (AD) is a complex pathology related to multiple causes including oxidative stress.

  48. Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. JAMA neurology 2018-11-01 Genetics

    The 751 study participants were older (median age [interquartile range], 87 years [51-105 years]), 395 (54%) were women, and 324 (44%) were APOE ε4 carriers.

  49. ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuron 2018-10-18 Disease mechanisms

    Through the generation of humanized FUS mice expressing full-length human FUS, we identify that when expressed at near endogenous murine FUS levels, both wild-type and ALS-causing and frontotemporal dementia (FTD)-causing mutations complement the essential function(s) of murine FUS.

  50. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Molecular psychiatry 2018-10-03 TREM2 and immune genetics

    TYROBP/DAP12 forms complexes with ectodomains of immune receptors (TREM2, SIRPβ1, CR3) associated with Alzheimer's disease (AD) and is a network hub and driver in the complement subnetwork identified by multi-scale gene network studies of postmortem human AD brain.

From across this tag

10 of the 1,153 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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