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prospective
1,139 studies tagged prospective, dated 1978-04-01 to 2026-09-26. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Public awareness of the hearing loss-dementia link and self-reported behavioral changes in middle- to older-aged Canadians 2026-09-26
- Patterns of modifiable lifestyle, behavioural and health-related risk factors and their associations with incident dementia in UK Biobank 2026-09-25
- Excess hypoglycaemia-related hospitalisation in older adults with comorbid type 2 diabetes and dementia: a UK Biobank cohort study 2026-09-16
Studies
1,139 studies carry this tag.
Date range
1978 to 2026
Top journals
- Neurology 134
- Alzheimer s & Dementia 52
- Alzheimer's & dementia : the journal of the Alzheimer's Association 33
- Journal of the American Geriatrics Society 32
- JAMA neurology 27
362 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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High concentrations of Abeta(1-40) but not Abeta(1-42) at baseline were associated with an increased risk of dementia.
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Human immunodeficiency virus-1 (HIV-1)-infected and immune-activated macrophages and microglia secrete neurotoxins.
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41/100
Dementia and age-related macular degeneration (AMD) are major causes of disability in the elderly. n-3 Fatty acids, particularly docosahexaenoic acid (DHA), are highly concentrated in brain and retinal tissue and may prevent or delay the progression of dementia and AMD.
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Moderate intake of unsaturated fats at midlife is protective, whereas a moderate intake of saturated fats may increase the risk of dementia and AD, especially among ApoE epsilon4 carriers.
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During the 6534 person-years of follow-up (mean, 5.02 years per person), 440 subjects were diagnosed as having dementia, including 333 with Alzheimer disease.
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Cognitive function was inversely related to all measures of disease pathology, indicating lower function at more severe levels of pathology.
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In our study, TSH was related neither to risk of AD nor with early MRI markers thereof, arguing against an important role of thyroid function in the development of AD.
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Caregivers had higher levels of 8 am, 5 pm, and 9 pm log cortisol as well as higher perceived stress than noncaregivers.
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Potentially modifiable risk factors from early and midlife, with a cumulative detrimental effect on the brain, contribute to risk of dementia.
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51/100
Vascular risk factors for Alzheimer disease (AD) and vascular dementia (VaD) have been evaluated; however, few studies have compared risks by dementia subtypes and sex.
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This is the first demonstration of gender differences in brain ferritin iron levels.
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Although cross-sectional studies found an association between anaemia and dementia, longitudinal studies provided contradictory results.
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In this large multicentre and long-term population-based study, some well-known risk factors for dementia, of vascular and Alzheimer's type, are confirmed but not others.
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Familism has been pointed out as a key value in Hispanic culture that may or may not be associated with caregiver distress.
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These results suggest that regular exercise is associated with a delay in onset of dementia and Alzheimer disease, further supporting its value for elderly persons.
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Vascular and inflammatory factors may play an important role in the pathogenesis of dementia.
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In the Cardiovascular Health Cognition Study, consumption of fatty fish was associated with a reduced risk of dementia and Alzheimer disease for those without the APOE epsilon4 allele.
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Leisure-time physical activity at midlife at least twice a week was associated with a reduced risk of dementia and AD (odds ratio [OR] 0.48 [95% CI 0.25-0.91] and 0.38 [0.17-0.85], respectively), even after adjustments for age, sex, education, follow-up time, locomotor disorders, APOE genotype, vascular disorders, smoking, and alcohol drinking.
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The gender-specific results for obesity, but not for diabetes, suggests that the underlying mechanisms linking them to cognition may be different.
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Obesity at midlife is associated with an increased risk of dementia and AD later in life.
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The data do not support an association between serum total cholesterol or high density lipoprotein in late life and subsequent risk of dementia or Alzheimer disease (AD).
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Because cardiovascular (CV) risk factors have been associated with declines in cognitive functions and late life dementia, CV risk factors should also be associated with brain atrophy.
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Over an average follow-up of 4 y, dementia developed in 112 subjects, including 70 who received a diagnosis of AD.
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The relation of blood pressure with cognitive function and dementia has, in recent years, received much attention from epidemiological research.
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Older adults with CVD other than stroke had a higher risk of dementia and AD than did those without CVD.
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68/100
Tracking over 10,000 people for 27 years, this landmark study found that being obese in midlife (in your 40s) nearly doubled the risk of developing dementia decades later, and being overweight also raised the risk, independent of whether someone later developed diabetes or heart disease.
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Unsaturated fatty acids are important constituents of neuronal cell membranes and have neuroprotective, antioxidant, and anti-inflammatory properties.
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Vascular disease in the brain is prevalent among incident dementia cases.
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High cholesterol in late life was associated with decreased dementia risk, which is in contrast to previous studies suggesting high cholesterol in mid-life is a risk factor for later dementia.
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61/100
Obesity in middle age increases the risk of future dementia independently of comorbid conditions.
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Physical activity may help preserve cognitive function and decrease dementia risk, but epidemiologic findings are inconsistent.
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Although statin use might be less frequent in those with prevalent dementia, we found no association between statin use and subsequent onset of dementia or AD.
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The presence of multiple cardiovascular risk factors at midlife substantially increases risk of late-life dementia in a dose dependent manner.
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56/100
Family history of dementia was associated with an increased risk of dementia and AD in this very old population, but only among APOE epsilon4 carriers.
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On average, the risk of dementia seems to increase with the number of episodes in depressive and bipolar affective disorders.
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63/100
Employing time-dependent proportional hazards modeling, the authors found no significant association between statin use and incident dementia or probable AD.
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In this population, among those who progressed to dementia, 60% progressed to AD and 33% to VaD.
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Light-to-moderate alcohol intake is associated with a lower prevalence of vascular brain findings and, in APOE epsilon4 carriers, hippocampal and amygdalar atrophy on MRI.
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White matter lesions, especially in the periventricular region, increase the risk of dementia in elderly people.
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Diabetes mellitus increases the risk of dementia, and VaD in particular, in very old people.
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Older age is associated with increased HAD in this HIV-1 cohort.
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We conclude that patients with mild cognitive impairment and depression are at more than twice the risk of developing dementia of Alzheimer type as those without depression.
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A total of 267 (3.8%) women had diabetes and 297 (4.2%) had IFG.
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Energy adjusted niacin intake had a protective effect on development of AD and cognitive decline.
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Renal impairment is associated with an increased risk of carotid atherosclerosis and stroke, determinants of cognitive dysfunction and dementia.
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The recent availability of longitudinal data on the possible association of different lifestyles with dementia and Alzheimer's disease (AD) allow some preliminary conclusions on this topic.
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In the estrogen-alone trial, 47 participants were diagnosed with probable dementia, of whom 28 were assigned to CEE and 19 to placebo (hazard ratio [HR], 1.49; 95% confidence interval [CI], 0.83-2.66).
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Plasma levels of inflammatory proteins are increased before clinical onset of dementia, Alzheimer disease, and vascular dementia.
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Antioxidants have been hypothesized to protect against Alzheimer's disease, but studies conducted in late life have been inconsistent.
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Consumption of up to three servings of wine daily is associated with a lower risk of AD in elderly individuals without the APOE epsilon-4 allele.
From across this tag
8 of the 1,130 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Long‐Term Incidence of Dementia Following Transient Ischemic Attack: A Longitudinal Cohort Study
- Cardiovascular diseases and risk of dementia in the general population
- Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study
- Genetic Risk for Alzheimer Disease, Midlife Hypertension, and Dementia: The ARIC Neurocognitive Study
- Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort
- Vascular risk factors, cognitive decline, and dementia
- Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI
- Dietary antioxidants and long-term risk of dementia