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Home › Research › Topics › presenilin

presenilin

343 studies tagged presenilin, dated 1985-12-01 to 2026-10-26. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Precision Nanocrystal Theranostics for Neurodegenerative Proteopathies: Strategies to Cross the Blood-Brain Barrier and Target Protein Aggregation 2026-10-26
  2. Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons 2026-10-24
  3. Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization 2026-10-20

Studies

343 studies carry this tag.

Date range

1985 to 2026

Top journals

  • Proceedings of the National Academy of Sciences of the United States of America 35
  • Nature 23
  • Neuron 14
  • The Journal of biological chemistry 14
  • Science (New York, N.Y.) 12

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Precision Nanocrystal Theranostics for Neurodegenerative Proteopathies: Strategies to Cross the Blood-Brain Barrier and Target Protein Aggregation

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Preprints.org 2026-10-26 Vascular contributions

    This review examines nanocrystal-based theranostic platforms as a promising method to overcome the blood-brain barrier (BBB) in neurodegenerative diseases like Alzheimer’s and Parkinson’s. These neurological diseases involve gradual protein misfolding and aggregation, causing neuronal damage and loss.

  2. Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-24 Risk genes beyond APOE

    Familial Alzheimer’s disease (AD) mutations in amyloid precursor protein (APP) alter amyloid-β (Aβ) secretion profiles, but their effects on neuronal protein and lipid homeostasis remain incompletely understood.

  3. Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-20 Inflammation and the immune system

    Soluble amyloid-β (Aβ) oligomers are considered the primary neurotoxic species in Alzheimer’s disease, yet the relationship between oligomer structure and biological activity remains poorly understood.

  4. Mapping post-translational modifications across amyloid-β deposits in Alzheimer’s disease: A neuropathologic survey with in vitro functional analysis of nitration

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-10-18 Treatments

    Distinct PTMs delineate the compartment-specific architectural signatures of Aβ deposits.

  5. Insulin fails to mitigate amyloid pathology but modulates intestinal morphology in the 5xFAD model revealed by synchrotron-based XPCT

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-16 Disease mechanisms

    Intranasal insulin has been investigated as a metabolic intervention in Alzheimer’s disease (AD), but its effects across the brain–gut axis remain unclear.

  6. Carbonic anhydrase inhibition rescues heart function in the Tg2576 Alzheimer’s mouse model by ameliorating cardiac amyloid-β pathology and neurotrophic-signaling impairment

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-09 Vascular contributions

    FDA-approved carbonic anhydrase inhibitors (CAIs) have shown robust efficacy in reducing amyloid-β (Aβ) pathology, neurodegeneration, and cerebrovascular dysfunction in Alzheimer’s disease (AD) and cerebral amyloid angiopathy (CAA) models, highlighting carbonic anhydrase (CAs) as a promising, previously untapped therapeutic target for AD and vascular contribution to dementia.

  7. Distinct Aβ40 and Aβ42 co-assembly pathways with free lipids: Experiment-driven MD study

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-10-02 Risk factors

    Amyloid β-protein (Aβ), which is known for its role in Alzheimer's disease (AD), is also involved in several physiological functions.

  8. Evidence of P-glycoprotein mediated bidirectional transport of beta-amyloid (Ab40 and Ab42) through CLEFF4 cells

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2026-09-25 Risk genes beyond APOE

    2µM FAM labelled β-amyloid 1–40 was transported through CLEFF4 cells with an apparent permeability (Papp) of 4.47x10 − 6 cm/sec in the efflux direction (Basolateral (Bas) to apical (Ap)) while Ap to Bas direction was only 1.67x10 − 6 cm/sec.

  9. Profiling of Aggregated Amyloid β42-induced Proteomic Alterations in KOLF2.1J Induced Pluripotent Stem Cell-derived Neurons

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-09-25 Tau biomarkers

    Amyloid β (Aβ) plaques are a hallmark of Alzheimer’s disease (AD).

  10. Amyloid precursor protein: an Achilles’ heel to exploit in the treatment of prostate cancer

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-09-22 Risk genes beyond APOE

    Drugs that target APP have already been developed for AD and our data suggests they offer an exciting opportunity for repurposing in the treatment of prostate cancer.

  11. Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human Brain

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-09-11 Treatments

    Structural studies of amyloid fibrils extracted from brain tissue have identified disease-specific fibril polymorphs.

  12. Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer’s disease

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv 2026-07-28 Brain scans and imaging

    Structured Abstract INTRODUCTION Alzheimer’s disease (AD) progresses over decades, yet plasma biomarkers that resolve disease stage rather than simply detect disease remain scarce.

  13. CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer's disease patients

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's research & therapy 2025-07-22 Treatments

    Ninety-four proteins differentiated in the high-risk group compared to low-risk (p < 0.05), none surviving FDR correction.

  14. Chiral Bimetallic Pt@Au Octapods with Spiral Four-Petal Flower-Like Symmetric Configuration as Sensitive SERS Probes

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Angewandte Chemie (International ed. in English) 2025-03-07 Biomarkers

    Here, we synthesized chiral bimetallic Pt@Au octapods by using l/d-cysteine-threonine (CT) dipeptide as chiral ligands.

  15. Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurobiology of aging 2024-10-19 Biomarkers

    The hAβ-KI and APPSAA-KI are two amyloid models that harbor mutations in the endogenous mouse App gene.

  16. Glutamate Transporter 1 as a Novel Negative Regulator of Amyloid β

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cells 2024-09-24 Biomarkers

    Glutamate transporter-1 (GLT-1) dynamics are implicated in excitotoxicity and Alzheimer's disease (AD) progression.

  17. Cortical neurodegeneration caused by Psen1 mutations is independent of Aβ

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2024-08-13 Risk genes beyond APOE

    Mutations in the PSEN genes are the major cause of familial Alzheimer's disease, and presenilin (PS) is the catalytic subunit of γ-secretase, which cleaves type I transmembrane proteins, including the amyloid precursor protein (APP) to release Aβ peptides.

  18. Repurposing Anidulafungin for Alzheimer's Disease via Fragment-Based Drug Discovery

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. ACS chemical neuroscience 2024-08-03 Drug development

    The misfolding and aggregation of beta-amyloid (Aβ) peptides have been implicated as key pathogenic events in the early stages of Alzheimer's disease (AD).

  19. The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv : the preprint server for biology 2024-06-28 Biomarkers

    Aβ42/40 and Aβ37/42 ratios were associated with AAO across PSEN2 variants, strongly driven by PSEN2 variants with PSEN1 homologs.

  20. Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Acta neuropathologica 2024-06-10 Biomarkers

    Β-site amyloid precursor protein (APP) cleaving enzyme (BACE1) is a crucial protease in the production of amyloid-β (Aβ) in Alzheimer's disease (AD) patients.

  21. Palladium nanoballs coupled with smartphone-thermal reader for photothermal lateral flow immunoassay of Aβ 1-40

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of materials chemistry. B 2024-03-06 Cognitive tests and assessment

    Amyloid beta 1-40 (Aβ 1-40) is one of the most abundant substances in the body with the capacity to form insoluble aggregates and is a universal biomarker for the prediction of Alzheimer's disease.

  22. Developing a Gene Therapy for the Treatment of Autosomal Dominant Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Human gene therapy 2023-10 Risk genes beyond APOE

    Autosomal dominant Alzheimer's disease (ADAD) is a rare early-onset form of Alzheimer's disease, caused by dominant mutations in one of three genes: presenilin 1, presenilin 2, and amyloid β precursor protein (APP).

  23. Upregulation of endocytic protein expression in the Alzheimer's disease male human brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging brain 2023-06-21 Biomarkers

    Amyloid-beta (Aβ) is produced from amyloid precursor protein (APP) primarily after APP is internalised by endocytosis and clathrin-mediated endocytic processes are altered in Alzheimer's disease (AD).

  24. β 2 -Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature neuroscience 2023-06-01 Drug development

    Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease (AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to trigger AD-associated degeneration, and whether other additional pathological factors drive AD pathogenesis remains unclear.

  25. Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2023-05-08 Risk genes beyond APOE

    Presenilin 1 (PSEN1) is a part of the gamma secretase complex with several interacting substrates, including amyloid precursor protein (APP), Notch, adhesion proteins and beta catenin.

  26. Amyloid-beta aggregation implicates multiple pathways in Alzheimer's disease: Understanding the mechanisms

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in neuroscience 2023-04-11 Drug development

    Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by tau pathology and accumulations of neurofibrillary tangles (NFTs) along with amyloid-beta (Aβ).

  27. An Alternative View of Familial Alzheimer's Disease Genetics

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2023 Risk genes beyond APOE

    Probabilistic and parsimony-based arguments regarding available genetics data are used to propose that Hardy and Higgin's amyloid cascade hypothesis is valid but is commonly interpreted too narrowly to support, incorrectly, the primacy of the amyloid-β peptide (Aβ) in driving Alzheimer's disease pathogenesis.

  28. PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. International journal of molecular sciences 2022-11-01 Risk genes beyond APOE

    Presenilin-2 (PSEN2) mutation Thr421Met was identified from a 57-years old patient with early onset Alzheimer's disease (EOAD) for the first time in Korea.

  29. Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. International journal of molecular sciences 2022-09-19 Risk factors

    Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset Alzheimer's disease (EOAD).

  30. A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell reports. Medicine 2022-09-12 Risk genes beyond APOE

    The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease's initial preclinical phase.

  31. α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cellular and molecular life sciences : CMLS 2022-08-02 Vascular contributions

    Cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid β (Aβ) deposits and causes dementia and cerebral hemorrhage.

  32. The amyloid plaque proteome in early onset Alzheimer's disease and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica communications 2022-04-13 Down syndrome and Alzheimer's

    Amyloid plaques contain many proteins in addition to beta amyloid (Aβ).

  33. The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular therapy : the journal of the American Society of Gene Therapy 2022-04-04 Disease mechanisms

    The development of new therapeutic avenues that target the early stages of Alzheimer's disease (AD) is urgently necessary.

  34. CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular therapy. Nucleic acids 2022-03-28 Biomarkers

    Presenilin 1 (PS1) is a central component of γ-secretase, an enzymatic complex involved in the generation of the amyloid-β (Aβ) peptide that deposits as plaques in the Alzheimer's disease (AD) brain.

  35. Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2022-03-17 Biomarkers

    Aberrant cleavage of amyloid precursor protein (APP) by γ-secretase is closely associated with Alzheimer’s disease (AD). γ-secretase activating protein (GSAP) specifically promotes γ-secretase–mediated cleavage of APP.

  36. A Possible Pathogenic PSEN2 Gly56Ser Mutation in a Korean Patient with Early-Onset Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. International journal of molecular sciences 2022-03-09 Risk genes beyond APOE

    Early-onset Alzheimer’s disease (EOAD) is characterized by the presence of neurological symptoms in patients with Alzheimer’s disease (AD) before 65 years of age.

  37. Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neural regeneration research 2022-01 Risk genes beyond APOE

    The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form.

  38. Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Brain : a journal of neurology 2021-11-29 Biomarkers

    In vitro studies of autosomal dominant Alzheimer's disease implicate longer amyloid-β peptides in disease pathogenesis; however, less is known about the behaviour of these mutations in vivo.

  39. Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational psychiatry 2021-11-03 Risk genes beyond APOE

    Presenilin (PS) with a genetic mutation generates abundant β-amyloid protein (Aβ) 43.

  40. Targeting γ-Secretase for Familial Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents 2021-05-27 Risk genes beyond APOE

    Familial Alzheimer's disease (FAD) is a rare early-onset genetic form of a common dementia of old age.

  41. Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of nanobiotechnology 2021-04-29 Biomarkers

    Increasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia.

  42. Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of biological chemistry 2021-01-12 Biomarkers

    Production of amyloid β-protein (Aβ) is carried out by the membrane-embedded γ-secretase complex.

  43. Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell reports 2021-01-12 Risk genes beyond APOE

    Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer's disease (fAD).

  44. Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer’s Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's Disease 2021-01-05 Treatments

    In the aducanumab-treated mice, we identified 17 significantly regulated proteins that were associated with 1) mitochondria and metabolism (ACAT2, ATP5J, ETFA, EXOG, HK1, NDUFA4, NDUFS7, PLCB1, PPP2R4), 2) cytoskeleton and axons (ADD1, CAPZB, DPYSL3, MAG), 3) stress response (HIST1H1C/HIST1H1D, HSPA12A), and 4) AβPP trafficking/processing (CD81, GDI2).

  45. From monomer to fibril: Abeta‐amyloid binding to Aducanumab antibody studied by molecular dynamics simulation

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Proteins: Structure, Function, and Bioinformatics 2020-08-03 Treatments

    Alzheimer's disease is one of the most common causes of dementia.

  46. Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's research & therapy 2020-07-06 Biomarkers

    Our findings identify CatD as the principal intracellular Aβ-degrading protease identified to date, one that regulates Aβ42/40 ratios via differential degradation of Aβ42 vs. Aβ40.

  47. Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Seminars in cell & developmental biology 2020-05-14 Risk genes beyond APOE

    The rising prevalence of Alzheimer's disease (AD), together with the lack of effective treatments, portray it as one of the major health challenges of our times.

  48. New Insights into the Molecular Bases of Familial Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of personalized medicine 2020-04-19 Risk genes beyond APOE

    Like several neurodegenerative disorders, such as Prion and Parkinson diseases, Alzheimer's disease (AD) is characterized by spreading mechanism of aggregated proteins in the brain in a typical "prion-like" manner.

  49. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-04-17 Digital health tools

    In addition to Aβ and tau, ANXA5, VGF, GPM6A, and ACTZ are new signature proteins in AD EVs.

  50. Cryo-temperature effects on membrane protein structure and dynamics

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Physical chemistry chemical physics : PCCP 2020-03-11 Biomarkers

    Innovations in cryogenic electron microscopy (Cryo-EM) have led to high-quality structures of important proteins such as the ribosome and γ-secretase, the membrane protease that produces Aβ involved in Alzheimer's disease.

From across this tag

8 of the 343 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts