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Home › Research › Topics › presenilin

presenilin

344 studies tagged presenilin, dated 1985-12-01 to 2026-10-26. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Precision Nanocrystal Theranostics for Neurodegenerative Proteopathies: Strategies to Cross the Blood-Brain Barrier and Target Protein Aggregation 2026-10-26
  2. Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons 2026-10-24
  3. Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization 2026-10-20

Studies

344 studies carry this tag.

Date range

1985 to 2026

Top journals

  • Proceedings of the National Academy of Sciences of the United States of America 35
  • Nature 23
  • The Journal of biological chemistry 15
  • Neuron 14
  • Science (New York, N.Y.) 12

147 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1995-09-01 Drug development

    The lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12/Notch family of receptors for intercellular signals that specify cell fate.

  2. beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell 1995-05-01 Risk genes beyond APOE

    In several pedigrees of early onset familial Alzheimer's disease (FAD), point mutations in the beta-amyloid precursor protein (APP) gene are genetically linked to the disease.

  3. Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of cell biology 1995-04-01 Drug development

    Amyloid beta-protein (A beta), the principal constituent of senile plaques seen in Alzheimer's disease (AD), is derived by proteolysis from the beta-amyloid precursor protein (beta PP).

  4. Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1995-03-01 Tau biomarkers

    Biochemical and immunocytochemical analyses were performed to evaluate the composition of the amyloid beta protein (A beta) deposited in the brains of patients with Alzheimer's disease (AD).

  5. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 1995-02-01 Disease mechanisms

    Non-A beta component of Alzheimer's disease amyloid (NAC) is the second component in the amyloid from brain tissue of patients affected with Alzheimer's disease.

  6. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-12-01 Risk factors

    beta-Amyloid (beta A) is normally produced as a nontoxic soluble peptide.

  7. Rapid induction of Alzheimer A beta amyloid formation by zinc

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1994-09-01 Tau biomarkers

    A beta 1-40, a major component of Alzheimer's disease cerebral amyloid, is present in the cerebrospinal fluid and remains relatively soluble at high concentrations (less than or equal to 3.7 mM).

  8. Evidence that production and release of amyloid beta-protein involves the endocytic pathway

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1994-07-01 Risk genes beyond APOE

    Amyloid beta-protein (A beta), the 40-43-amino acid polypeptide that is the principal constituent of senile plaques found in Alzheimer's disease, is constitutively produced and released into medium of cultured cells by an unclear mechanism.

  9. Modulation of A beta adhesiveness and secretase site cleavage by zinc

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1994-04-01 Down syndrome and Alzheimer's

    Abnormalities of zinc homeostasis occur in Alzheimer's disease (AD), a dementia characterized by the aggregation of A beta in the brain, and in Down syndrome, a condition characterized by premature AD.

  10. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1994-04-01 Risk factors

    The 37-amino-acid polypeptide amylin is the principal constituent of the amyloid deposits that form in the islets of Langerhans in patients with type-2 diabetes mellitus, but its role in the pathogenesis of this disease is unresolved.

  11. Expression of alpha B-crystallin in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 1994-01-01 Biomarkers

    alpha B-crystallin is a member of the small heat-shock protein family.

  12. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-12-01 Brain tissue and pathology

    A neuropathological hallmark of Alzheimer disease (AD) is a widespread amyloid deposition.

  13. beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1993-11-01 Vascular contributions

    Reinvestigation of the chemical structure of beta-amyloid peptide (A beta) deposits in the vascular tissue of Alzheimer disease brains revealed that the 42-residue form A beta-(1-42), rather than the more soluble A beta-(1-40) form, is the predominant peptide.

  14. Re-evaluation of the structural organization of neuritic plaques in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 1993-11-01 Drug development

    We re-examined the relationship among synaptic pathology, subcellular abnormalities within neurites in the plaques and beta-amyloid deposits of Alzheimer's disease (AD) using laser confocal imaging and computer-aided serial section reconstruction techniques.

  15. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 1993-11-01 Down syndrome and Alzheimer's

    A beta, a nearly insoluble peptide, is generally assumed to irreversibly deposit and accumulate as senile plaques (SP) during the course of Alzheimer's disease (AD).

  16. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 1993-04-01 Inflammation and the immune system

    The progressive neurodegeneration of Alzheimer's disease has been hypothesized to be mediated, at least in part, by beta-amyloid protein.

  17. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 1993-02-01 Risk genes beyond APOE

    The beta-amyloid precursor protein (beta APP) is a membrane-spanning glycoprotein that is the source of the beta-amyloid peptide (beta AP) which accumulates as senile plaques in the brains of patients with Alzheimer's disease. beta APP is normally processed such that a cleavage occurs within the beta AP, liberating secreted forms of beta APP (APPss) from the cell.

  18. Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1993-01-01 Tau biomarkers

    The accumulation in brain of senile plaques containing beta-amyloid protein (A beta) is a defining feature of Alzheimer's disease.

  19. Complement activation by beta-amyloid in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences 1992-11-01 Inflammation and the immune system

    Alzheimer disease (AD) is characterized by excessive deposition of the beta-amyloid peptide (beta-AP) in the central nervous system.

  20. Production of the Alzheimer amyloid beta protein by normal proteolytic processing

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1992-10-01 Tau biomarkers

    The 4-kilodalton (39 to 43 amino acids) amyloid beta protein (beta AP), which is deposited as amyloid in the brains of patients with Alzheimer's diseases, is derived from a large protein, the amyloid beta protein precursor (beta APP).

  21. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1992-09-01 Tau biomarkers

    Cerebral deposition of the beta-amyloid peptide (A beta) is an invariant feature of Alzheimer's disease.

  22. Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of molecular biology 1992-06-01 Vascular contributions

    The A4 or beta-peptide (39 to 43 amino acid residues) is the principal proteinaceous component of amyloid deposits in Alzheimer's disease.

  23. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1992-06-01 Risk genes beyond APOE

    Progressive cerebral deposition of the amyloid beta-peptide is an early and invariant feature of Alzheimer's disease.

  24. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 1991-12-01 Down syndrome and Alzheimer's

    Microglial cells and astrocytes are closely associated with nearly all compact deposits of the amyloid beta-protein found in the senile plaques characteristic of Alzheimer's disease and trisomy 21.

  25. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1991-10-01 Risk genes beyond APOE

    Alzheimer's disease is a form of localized amyloidosis characterized by cerebral cortical amyloid plaques, neurofibrillary tangles, and amyloid deposits within the walls of leptomeningeal vessels.

  26. Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature 1991-10-01 Risk genes beyond APOE

    A mutation at codon 717 of the beta-amyloid precursor protein gene has been found to cosegregate with familial Alzheimer's disease in a single family.

  27. Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science 1991-07-12 Vascular contributions

    The secondary structures in solution of the synthetic, naturally occurring, amyloid beta peptides, residues 1 to 42 [beta (1-42)] and beta (1-39), and related fragments, beta (1-28) and beta (29-42), have been studied by circular dichroism and two-dimensional nuclear magnetic resonance spectroscopy.

  28. Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FEBS letters 1991-07-01 Tau biomarkers

    Recent studies indicated that the formation of a major constituent of Alzheimer's disease (AD) senile plaques, called beta A4-peptide, does not result from normal processing of its precursor, amyloid precursor protein (APP).

  29. Advances in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The FASEB Journal 1991-03-01 Disease mechanisms

    The problem of the etiology of Alzheimer's disease has not been solved.

  30. Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1991-03-01 Drug development

    Neurofibrillary tangles (NFTs), a hallmark of Alzheimer disease, are commonly located in perikarya of neurons.

  31. Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology 1991-02-01 Drug development

    A central unresolved issue in Alzheimer's disease is the origin of the extracellular amyloid beta protein (A beta P) found in senile plaques and its relationship to the dystrophic neurites that intimately surround it.

  32. Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1990-06-01 Down syndrome and Alzheimer's

    Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by extensive amyloid deposition in the small leptomeningeal arteries and cortical arterioles, which lead to an early death of those afflicted in their fifth or sixth decade.

  33. Cleavage of amyloid beta peptide during constitutive processing of its precursor

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1990-06-01 Risk genes beyond APOE

    The amyloid beta peptide (A beta P) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP).

  34. Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1990-05-01 Down syndrome and Alzheimer's

    Protease nexin-II (PN-II) [amyloid beta-protein precursor (APP)] and the amyloid beta-protein are major constituents of neuritic plaques and cerebrovascular deposits in individuals with Alzheimer's disease and Down syndrome.

  35. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1990-04-01 Risk genes beyond APOE

    The beta-amyloid protein (beta/A4), derived from a larger amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease.

  36. A4 protein in Alzheimer's disease: primary and secondary cellular events in extracellular amyloid deposition

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 1989-11-01 Biomarkers

    This study was designed to investigate the role of serum proteins, microglia, glial fibrillary acidic protein (GFAP) positive cells and dystrophic neurites in the genesis of cerebral amyloid.

  37. Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1989-09-01 Down syndrome and Alzheimer's

    Alzheimer's disease is the most common cause of progressive intellectual failure in aged humans.

  38. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1989-07-01 Risk genes beyond APOE

    Amyloid deposition in senile plaques and the cerebral vasculature is a marker of Alzheimer's disease.

  39. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell 1989-04-01 Tau biomarkers

    To study the putative precursor proteins (PreA4(695), PreA4(751), and PreA4(770] of Alzheimer's disease A4 amyloid protein, polyclonal and monoclonal antibodies were raised against a recombinant bacterial PreA4(695) fusion protein.

  40. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell 1988-02-01 Treatments

    Two approaches--molecular cloning and immunochemical analysis--have identified one of the components of Alzheimer's disease amyloid deposits as the serine protease inhibitor alpha 1-antichymotrypsin.

  41. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1987-12-01 Risk factors

    Deposition of amyloid in pancreatic islets is a common feature in human type 2 diabetic subjects but because of its insolubility and low tissue concentrations, the structure of its monomer has not been determined.

  42. The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1987-09-01 Down syndrome and Alzheimer's

    Amyloid beta-protein (AP) is a peptide of relative molecular mass (Mr) 42,000 found in the senile plaques, cerebrovascular amyloid deposits, and neurofibrillary tangles of patients with Alzheimer's disease and Down's syndrome (trisomy 21).

  43. Conservation of Brain Amyloid Proteins in Aged Mammals and Humans with Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science 1987-02-20 Vascular contributions

    The formation of clusters of altered axons and dendrites surrounding extracellular deposits of amyloid filaments (neuritic plaques) is a major feature of the human brain in both aging and Alzheimer's disease.

  44. Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences 1985-12-01 Vascular contributions

    A synthetic peptide (Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr), homologous to the amino terminus of a protein purified from cerebrovascular amyloid (beta protein), induced antibodies in BALB/c mice that were used immunohistochemically to stain not only amyloid-laden cerebral vessels but neuritic plaques as well.

From across this tag

8 of the 344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts