% alzhub.org topic: presenilin
% Source: https://alzhub.org/topic/presenilin
% 343 entries, in the order the page lists them. Built from alzhub.org's own records.
% 0 entries have no readable author in the source record and carry no author field.

@article{ujjwal2026-82239f86,
  author  = {Ujjwal, R. R. and Kumar, S. and Jain, S. and Shukla, R. and Sona, C.},
  title   = {{Precision Nanocrystal Theranostics for Neurodegenerative Proteopathies: Strategies to Cross the Blood-Brain Barrier and Target Protein Aggregation}},
  journal = {Preprints.org},
  year    = {2026},
  doi     = {10.20944/preprints202610.2386.v1},
  url     = {https://doi.org/10.20944/preprints202610.2386.v1}
}

@article{munozestrada2026-3abeafdf,
  author  = {Muñoz-Estrada, J. and Jiang, Y. and Meyer, J. G.},
  title   = {{Temporal Proteomics Links the APP London Mutation to Early Cholesterol Remodeling Cell Programs in Human Neurons}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.20.760505},
  url     = {https://doi.org/10.64898/2026.10.20.760505}
}

@article{dinakarapandian2026-cf0b65f1,
  author  = {Dinakarapandian, D. M. and Rao Sudarshan, T. and Griffin, M. N. and Ramaswamy, P. and Nguyen, P. H. and Chiu, T. and Li, C. and Kamalaldinezabadi, S. S. and others},
  title   = {{Stimulating microglial neuroinflammation with amyloid-beta oligomers compatible with solid-state NMR structural characterization}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.14.759149},
  url     = {https://doi.org/10.64898/2026.10.14.759149}
}

@article{basile2026-35f2647e,
  author  = {Basile, S. and Schipper, F. and Zimbone, S. and Vermorgen, S. M. and Bellia, F. and Parisi, C. and Sortino, S. and Walter, J. and others},
  title   = {{Mapping post-translational modifications across amyloid-β deposits in Alzheimer’s disease: A neuropathologic survey with in vitro functional analysis of nitration}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10769225/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10769225/v1}
}

@article{ayan2026-b4d44c1a,
  author  = {Ayan, E. and Palermo, F. and Cavioli, G. and Bostan, S. and Dogan, B. Z. and Kilic, K. and Kaplan, A. A. and Bukreeva, I. and others},
  title   = {{Insulin fails to mitigate amyloid pathology but modulates intestinal morphology in the 5xFAD model revealed by synchrotron-based XPCT}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.10.758244},
  url     = {https://doi.org/10.64898/2026.10.10.758244}
}

@article{elia2026-32eba34d,
  author  = {Elia, A. and Vazquez-Torres, R. and Carey, A. and Wolf, M. and Gade, V. R. and Alves, M. and Fossati, S.},
  title   = {{Carbonic anhydrase inhibition rescues heart function in the Tg2576 Alzheimer’s mouse model by ameliorating cardiac amyloid-β pathology and neurotrophic-signaling impairment}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.10.08.757731},
  url     = {https://doi.org/10.64898/2026.10.08.757731}
}

@article{pandey2026-72021b1f,
  author  = {Pandey, R. and Olabi, T. and Lee, M. and Urbanc, B.},
  title   = {{Distinct Aβ40 and Aβ42 co-assembly pathways with free lipids: Experiment-driven MD study}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.28.755027},
  url     = {https://doi.org/10.64898/2026.09.28.755027}
}

@article{crowe2026-08036707,
  author  = {Crowe, A.},
  title   = {{Evidence of P-glycoprotein mediated bidirectional transport of beta-amyloid (Ab40 and Ab42) through CLEFF4 cells}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10926932/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10926932/v1}
}

@article{jin2026-3ef10c5a,
  author  = {Jin, B. and Li, Z. and Hao, Y. and Kowal, I. and Epstein, J. and Santiana, M. and Weller, C. A. and Nalls, M. A. and others},
  title   = {{Profiling of Aggregated Amyloid β42-induced Proteomic Alterations in KOLF2.1J Induced Pluripotent Stem Cell-derived Neurons}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.20.753014},
  url     = {https://doi.org/10.64898/2026.09.20.753014}
}

@article{alhadrami2026-c6d8e695,
  author  = {Alhadrami, M. and Gill, E. and Perks, C. M. and Barker, R. M.},
  title   = {{Amyloid precursor protein: an Achilles’ heel to exploit in the treatment of prostate cancer}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.21.752657},
  url     = {https://doi.org/10.64898/2026.09.21.752657}
}

@article{vandenheuvel2026-b5f4b141,
  author  = {van den Heuvel, L. and Stähli, D. A. and Radecke, J. and Daraspe, J. and Shafiei, N. and Lewis, A. J. and van de Berg, W. D. J. and Genoud, C. and others},
  title   = {{Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human Brain}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.09.04.749518},
  url     = {https://doi.org/10.64898/2026.09.04.749518}
}

@article{mahmoudi2026-7fb049ee,
  author  = {Mahmoudi, N. and Ghaffari, B. and Rogale, K. and Cheeseman, S. and Ritz, D. and Schmidt, A. and Han, L. and Li, Q. and others},
  title   = {{Deep nanoparticle protein corona plasma proteomics resolves a stage-specific peripheral signature of Alzheimer’s disease}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.07.25.740710},
  url     = {https://doi.org/10.64898/2026.07.25.740710}
}

@article{oosthoek2025-40696469,
  author  = {Oosthoek, Marlies and Vijverberg, Everard G B and Blujdea, Elena R and Veld, Sjors G J G In't and Avilés, Martín Pucheu and Zsadanyi, Sára E and Hok-A-Hin, Yanaika S and Visser, Allerdien and others},
  title   = {{CHIT1 and DDAH1 levels relate to amyloid-related imaging abnormalities risk profile in Alzheimer's disease patients}},
  journal = {Alzheimer's research \& therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01799-3},
  pmid    = {40696469},
  url     = {https://doi.org/10.1186/s13195-025-01799-3}
}

@article{li2025-39991952,
  author  = {Li, Dexiang and Wang, Gaoyang and Sun, Maozhong and Qu, Aihua and Xu, Chuanlai and Wang, Qing and Hao, Changlong and Kuang, Hua},
  title   = {{Chiral Bimetallic Pt@Au Octapods with Spiral Four-Petal Flower-Like Symmetric Configuration as Sensitive SERS Probes}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2025},
  doi     = {10.1002/anie.202501894},
  pmid    = {39991952},
  url     = {https://doi.org/10.1002/anie.202501894}
}

@article{lu2025-39447490,
  author  = {Lu, Wenyan and Shue, Francis and Kurti, Aishe and Jeevaratnam, Suren and Macyczko, Jesse R and Roy, Bhaskar and Izhar, Taha and Wang, Ni and others},
  title   = {{Amyloid pathology and cognitive impairment in hAβ-KI and APPSAA-KI mouse models of Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2025},
  doi     = {10.1016/j.neurobiolaging.2024.10.005},
  pmid    = {39447490},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2024.10.005}
}

@article{sinha2024-39404364,
  author  = {Sinha, Priyanka and Turchyna, Yuliia and Mitchell, Shane Patrick Clancy and Sadek, Michael and Armagan, Gokce and Perrin, Florian and Maesako, Masato and Berezovska, Oksana},
  title   = {{Glutamate Transporter 1 as a Novel Negative Regulator of Amyloid β}},
  journal = {Cells},
  year    = {2024},
  doi     = {10.3390/cells13191600},
  pmid    = {39404364},
  url     = {https://doi.org/10.3390/cells13191600}
}

@article{yan2024-39136994,
  author  = {Yan, Kuo and Zhang, Chen and Kang, Jongkyun and Montenegro, Paola and Shen, Jie},
  title   = {{Cortical neurodegeneration caused by Psen1 mutations is independent of Aβ}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2024},
  doi     = {10.1073/pnas.2409343121},
  pmid    = {39136994},
  url     = {https://doi.org/10.1073/pnas.2409343121}
}

@article{xie2024-39096284,
  author  = {Xie, Siqi and Liang, Yumei and Song, Yang and Li, Tingting and Jia, Jianping},
  title   = {{Repurposing Anidulafungin for Alzheimer's Disease via Fragment-Based Drug Discovery}},
  journal = {ACS chemical neuroscience},
  year    = {2024},
  doi     = {10.1021/acschemneuro.4c00150},
  pmid    = {39096284},
  url     = {https://doi.org/10.1021/acschemneuro.4c00150}
}

@article{liu2024-38979391,
  author  = {Liu, Lei and Schultz, Stephanie A and Saba, Adriana and Yang, Hyun-Sik and Li, Amy and Selkoe, Dennis J and Chhatwal, Jasmeer P},
  title   = {{The pathogenicity of PSEN2 variants is tied to Aβ production and homology to PSEN1}},
  journal = {bioRxiv : the preprint server for biology},
  year    = {2024},
  doi     = {10.1101/2024.06.22.600217},
  pmid    = {38979391},
  url     = {https://doi.org/10.1101/2024.06.22.600217}
}

@article{gao2024-38856925,
  author  = {Gao, Feng and Zhang, Mengguo and Wang, Qiong and Ni, Ming and Liu, Chang and Deng, Kexue and Xie, Qiang and Wang, Shicung and others},
  title   = {{Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer's disease}},
  journal = {Acta neuropathologica},
  year    = {2024},
  doi     = {10.1007/s00401-024-02750-w},
  pmid    = {38856925},
  url     = {https://doi.org/10.1007/s00401-024-02750-w}
}

@article{cai2024-38372378,
  author  = {Cai, Xiaoli and Luo, Yangxing and Song, Yang},
  title   = {{Palladium nanoballs coupled with smartphone-thermal reader for photothermal lateral flow immunoassay of Aβ 1-40}},
  journal = {Journal of materials chemistry. B},
  year    = {2024},
  doi     = {10.1039/d3tb02641h},
  pmid    = {38372378},
  url     = {https://doi.org/10.1039/d3tb02641h}
}

@article{moore2023-37578141,
  author  = {Moore, Benjamin and Sharma, Apurwa and Goulet, Martin and Suter, Tracey and Pelletier, Carolyn and Hu, Ruoxi and Schaeffer, Eric and Kelleher, Raymond J},
  title   = {{Developing a Gene Therapy for the Treatment of Autosomal Dominant Alzheimer's Disease}},
  journal = {Human gene therapy},
  year    = {2023},
  doi     = {10.1089/hum.2023.092},
  pmid    = {37578141},
  url     = {https://doi.org/10.1089/hum.2023.092}
}

@article{alsaqati2023-37449017,
  author  = {Alsaqati, Mouhamed and Thomas, Rhian S and Kidd, Emma J},
  title   = {{Upregulation of endocytic protein expression in the Alzheimer's disease male human brain}},
  journal = {Aging brain},
  year    = {2023},
  doi     = {10.1016/j.nbas.2023.100084},
  pmid    = {37449017},
  url     = {https://doi.org/10.1016/j.nbas.2023.100084}
}

@article{zhao2023-37264159,
  author  = {Zhao, Y. and Zheng, Q. and Hong, Y. and Gao, Y. and Hu, J. and Lang, M. and Zhang, H. and Zhou, Y. and others},
  title   = {{β 2 -Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice}},
  journal = {Nature neuroscience},
  year    = {2023},
  doi     = {10.1038/s41593-023-01352-1},
  pmid    = {37264159},
  url     = {https://doi.org/10.1038/s41593-023-01352-1}
}

@article{yang2023-37176125,
  author  = {Yang, Youngsoon and Bagyinszky, Eva and An, Seong Soo A},
  title   = {{Presenilin-1 (PSEN1) Mutations: Clinical Phenotypes beyond Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2023},
  doi     = {10.3390/ijms24098417},
  pmid    = {37176125},
  url     = {https://doi.org/10.3390/ijms24098417}
}

@article{iliyasu2023-37113145,
  author  = {Iliyasu, M. O. and Musa, S. A. and Oladele, S. B. and Iliya, A. I.},
  title   = {{Amyloid-beta aggregation implicates multiple pathways in Alzheimer's disease: Understanding the mechanisms}},
  journal = {Frontiers in neuroscience},
  year    = {2023},
  doi     = {10.3389/fnins.2023.1081938},
  pmid    = {37113145},
  url     = {https://doi.org/10.3389/fnins.2023.1081938}
}

@article{lardelli2023-37718800,
  author  = {Lardelli, Michael},
  title   = {{An Alternative View of Familial Alzheimer's Disease Genetics}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2023},
  doi     = {10.3233/jad-230313},
  pmid    = {37718800},
  url     = {https://doi.org/10.3233/jad-230313}
}

@article{yang2022-36362122,
  author  = {Yang, YoungSoon and Bagyinszky, Eva and An, Seong Soo A and Kim, SangYun},
  title   = {{PSEN2 Thr421Met Mutation in a Patient with Early Onset Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms232113331},
  pmid    = {36362122},
  url     = {https://doi.org/10.3390/ijms232113331}
}

@article{bagaria2022-36142879,
  author  = {Bagaria, J. and Bagyinszky, E. and An, S. S. A.},
  title   = {{Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms231810970},
  pmid    = {36142879},
  url     = {https://doi.org/10.3390/ijms231810970}
}

@article{andersen2022-36099918,
  author  = {Andersen, Olav M and Bøgh, Nikolaj and Landau, Anne M and Pløen, Gro G and Jensen, Anne Mette G and Monti, Giulia and Ulhøi, Benedicte P and Nyengaard, Jens R and others},
  title   = {{A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency}},
  journal = {Cell reports. Medicine},
  year    = {2022},
  doi     = {10.1016/j.xcrm.2022.100740},
  pmid    = {36099918},
  url     = {https://doi.org/10.1016/j.xcrm.2022.100740}
}

@article{inoue2022-35916996,
  author  = {Inoue, Yasuteru and Tasaki, Masayoshi and Masuda, Teruaki and Misumi, Yohei and Nomura, Toshiya and Ando, Yukio and Ueda, Mitsuharu},
  title   = {{α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2022},
  doi     = {10.1007/s00018-022-04493-x},
  pmid    = {35916996},
  url     = {https://doi.org/10.1007/s00018-022-04493-x}
}

@article{drummond2022-35418158,
  author  = {Drummond, E. and Kavanagh, T. and Pires, G. and Marta-Ariza, M. and Kanshin, E. and Nayak, S. and Faustin, A. and Berdah, V. and others},
  title   = {{The amyloid plaque proteome in early onset Alzheimer's disease and Down syndrome}},
  journal = {Acta neuropathologica communications},
  year    = {2022},
  doi     = {10.1186/s40478-022-01356-1},
  pmid    = {35418158},
  url     = {https://doi.org/10.1186/s40478-022-01356-1}
}

@article{musardo2022-35390543,
  author  = {Musardo, Stefano and Therin, Sebastien and Pelucchi, Silvia and D'Andrea, Laura and Stringhi, Ramona and Ribeiro, Ana and Manca, Annalisa and Balducci, Claudia and others},
  title   = {{The development of ADAM10 endocytosis inhibitors for the treatment of Alzheimer's disease}},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year    = {2022},
  doi     = {10.1016/j.ymthe.2022.03.024},
  pmid    = {35390543},
  url     = {https://doi.org/10.1016/j.ymthe.2022.03.024}
}

@article{konstantinidis2022-35505961,
  author  = {Konstantinidis, Evangelos and Molisak, Agnieszka and Perrin, Florian and Streubel-Gallasch, Linn and Fayad, Sarah and Kim, Daniel Y and Petri, Karl and Aryee, Martin J and others},
  title   = {{CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation}},
  journal = {Molecular therapy. Nucleic acids},
  year    = {2022},
  doi     = {10.1016/j.omtn.2022.03.022},
  pmid    = {35505961},
  url     = {https://doi.org/10.1016/j.omtn.2022.03.022}
}

@article{jin2022-35298330,
  author  = {Jin, Chen and Wang, Jiaoni and Wang, Yumeng and Jia, Bojun and Guo, Xuefei and Yang, Guanghui and Xu, Peng and Greengard, Paul and others},
  title   = {{Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2022},
  doi     = {10.1073/pnas.2122292119},
  pmid    = {35298330},
  url     = {https://doi.org/10.1073/pnas.2122292119}
}

@article{shim2022-35328387,
  author  = {Shim, Kyu-Hwan and Kang, Min-Ju and Bae, Heewon and Kim, Danyeong and Park, Jiwon and An, Seong-Soo A and Jeong, Da-Eun},
  title   = {{A Possible Pathogenic PSEN2 Gly56Ser Mutation in a Korean Patient with Early-Onset Alzheimer's Disease}},
  journal = {International journal of molecular sciences},
  year    = {2022},
  doi     = {10.3390/ijms23062967},
  pmid    = {35328387},
  url     = {https://doi.org/10.3390/ijms23062967}
}

@article{hernandezsapiens2022-34100423,
  author  = {Hernandez-Sapiens, Mercedes A and Reza-Zaldívar, Edwin E and Márquez-Aguirre, Ana L and Gómez-Pinedo, Ulises and Matias-Guiu, Jorge and Cevallos, Ricardo R and Mateos-Díaz, Juan C and Sánchez-González, Víctor J and others},
  title   = {{Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease}},
  journal = {Neural regeneration research},
  year    = {2022},
  doi     = {10.4103/1673-5374.313016},
  pmid    = {34100423},
  url     = {https://doi.org/10.4103/1673-5374.313016}
}

@article{oconnor2021-33892504,
  author  = {O'Connor, Antoinette and Pannee, Josef and Poole, Teresa and Arber, Charles and Portelius, Erik and Swift, Imogen J and Heslegrave, Amanda J and Abel, Emily and others},
  title   = {{Plasma amyloid-β ratios in autosomal dominant Alzheimer's disease: the influence of genotype}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awab166},
  pmid    = {33892504},
  url     = {https://doi.org/10.1093/brain/awab166}
}

@article{kakuda2021-34728605,
  author  = {Kakuda, Nobuto and Takami, Mako and Okochi, Masayasu and Kasuga, Kensaku and Ihara, Yasuo and Ikeuchi, Takeshi},
  title   = {{Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation}},
  journal = {Translational psychiatry},
  year    = {2021},
  doi     = {10.1038/s41398-021-01684-1},
  pmid    = {34728605},
  url     = {https://doi.org/10.1038/s41398-021-01684-1}
}

@article{wolfe2021-35295247,
  author  = {Wolfe, Michael S},
  title   = {{Targeting γ-Secretase for Familial Alzheimer's Disease}},
  journal = {Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents},
  year    = {2021},
  doi     = {10.1007/s00044-021-02744-3},
  pmid    = {35295247},
  url     = {https://doi.org/10.1007/s00044-021-02744-3}
}

@article{cano2021-33926475,
  author  = {Cano, A. and Turowski, P. and Ettcheto, M. and Duskey, J. T. and Tosi, G. and Sánchez-López, E. and García, M. L. and Camins, A. and others},
  title   = {{Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges}},
  journal = {Journal of nanobiotechnology},
  year    = {2021},
  doi     = {10.1186/s12951-021-00864-x},
  pmid    = {33926475},
  url     = {https://doi.org/10.1186/s12951-021-00864-x}
}

@article{devkota2021-33450230,
  author  = {Devkota, S. and Williams, T. D. and Wolfe, M. S.},
  title   = {{Familial Alzheimer's disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues}},
  journal = {The Journal of biological chemistry},
  year    = {2021},
  doi     = {10.1016/j.jbc.2021.100281},
  pmid    = {33450230},
  url     = {https://doi.org/10.1016/j.jbc.2021.100281}
}

@article{arber2021-33440141,
  author  = {Arber, Charles and Lovejoy, Christopher and Harris, Lachlan and Willumsen, Nanet and Alatza, Argyro and Casey, Jackie M and Lines, Georgie and Kerins, Caoimhe and others},
  title   = {{Familial Alzheimer's Disease Mutations in PSEN1 Lead to Premature Human Stem Cell Neurogenesis}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2020.108615},
  pmid    = {33440141},
  url     = {https://doi.org/10.1016/j.celrep.2020.108615}
}

@article{bastrup2021-af6534d7,
  author  = {Bastrup, Joakim and Hansen, Kathrine H. and Poulsen, Thomas B.G. and Kastaniegaard, Kenneth and Asuni, Ayodeji A. and Christensen, Søren and Belling, Dorthe and Helboe, Lone and others},
  title   = {{Anti-Aβ Antibody Aducanumab Regulates the Proteome of Senile Plaques and Closely Surrounding Tissue in a Transgenic Mouse Model of Alzheimer’s Disease}},
  journal = {Journal of Alzheimer's Disease},
  year    = {2021},
  doi     = {10.3233/jad-200715},
  url     = {https://doi.org/10.3233/jad-200715}
}

@article{frost2020-87e1c4ad,
  author  = {Frost, Christina V. and Zacharias, Martin},
  title   = {{From monomer to fibril: Abeta‐amyloid binding to Aducanumab antibody studied by molecular dynamics simulation}},
  journal = {Proteins: Structure, Function, and Bioinformatics},
  year    = {2020},
  doi     = {10.1002/prot.25978},
  url     = {https://doi.org/10.1002/prot.25978}
}

@article{suire2020-32631408,
  author  = {Suire, C. N. and Abdul-Hay, S. O. and Sahara, T. and Kang, D. and Brizuela, M. K. and Saftig, P. and Dickson, D. W. and Rosenberry, T. L. and others},
  title   = {{Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00649-8},
  pmid    = {32631408},
  url     = {https://doi.org/10.1186/s13195-020-00649-8}
}

@article{chavezgutierrez2020-32418657,
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  title   = {{Mechanisms of neurodegeneration - Insights from familial Alzheimer's disease}},
  journal = {Seminars in cell \& developmental biology},
  year    = {2020},
  doi     = {10.1016/j.semcdb.2020.03.005},
  pmid    = {32418657},
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@article{dargenio2020-32325882,
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  title   = {{New Insights into the Molecular Bases of Familial Alzheimer's Disease}},
  journal = {Journal of personalized medicine},
  year    = {2020},
  doi     = {10.3390/jpm10020026},
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@article{muraoka2020-32301581,
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  title   = {{Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12089},
  pmid    = {32301581},
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@article{mehra2020-31971183,
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  journal = {Physical chemistry chemical physics : PCCP},
  year    = {2020},
  doi     = {10.1039/c9cp06723j},
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@article{hampel2021-32223911,
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  title   = {{The β-Secretase BACE1 in Alzheimer's Disease}},
  journal = {Biological psychiatry},
  year    = {2021},
  doi     = {10.1016/j.biopsych.2020.02.001},
  pmid    = {32223911},
  url     = {https://doi.org/10.1016/j.biopsych.2020.02.001}
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@article{galla2020-31991578,
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  title   = {{Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21030770},
  pmid    = {31991578},
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}

@article{deaton2020-32804090,
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  title   = {{Presenilin 1 Regulates Membrane Homeostatic Pathways that are Dysregulated in Alzheimer's Disease}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200598},
  pmid    = {32804090},
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}

@article{armiento2020-31529602,
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  title   = {{Peptide-Based Molecular Strategies To Interfere with Protein Misfolding, Aggregation, and Cell Degeneration}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2020},
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  pmid    = {31529602},
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}

@article{aathi2019-31831959,
  author  = {Aathi, Muthusankar and Piramanayagam, Shanmughavel},
  title   = {{From EST to structure models for functional inference of APP, BACE1, PSEN1, PSEN2 genes}},
  journal = {Bioinformation},
  year    = {2019},
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@article{kollmer2019-31664019,
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  title   = {{Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue}},
  journal = {Nature communications},
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@article{pendin2021-31606858,
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  title   = {{Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability}},
  journal = {Aging clinical and experimental research},
  year    = {2021},
  doi     = {10.1007/s40520-019-01341-0},
  pmid    = {31606858},
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@article{perov2019-31469892,
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  title   = {{Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspire Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents}},
  journal = {PLoS pathogens},
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@article{kwart2019-31416668,
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  title   = {{A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ}},
  journal = {Neuron},
  year    = {2019},
  doi     = {10.1016/j.neuron.2019.07.010},
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@article{mengel2020-31500908,
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  title   = {{A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family}},
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  year    = {2020},
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  pmid    = {31500908},
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@article{wolfe2019-31699328,
  author  = {Wolfe, Michael S},
  title   = {{In search of pathogenic amyloid β-peptide in familial Alzheimer's disease}},
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  year    = {2019},
  doi     = {10.1016/bs.pmbts.2019.07.002},
  pmid    = {31699328},
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}

@article{grimmer2019-31266021,
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  title   = {{Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease}},
  journal = {Neuro-degenerative diseases},
  year    = {2019},
  doi     = {10.1159/000500811},
  pmid    = {31266021},
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@article{arber2020-30980041,
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  title   = {{Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta}},
  journal = {Molecular psychiatry},
  year    = {2020},
  doi     = {10.1038/s41380-019-0410-8},
  pmid    = {30980041},
  url     = {https://doi.org/10.1038/s41380-019-0410-8}
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@article{gotz2019-30926830,
  author  = {Götz, Alexander and Högel, Philipp and Silber, Mara and Chaitoglou, Iro and Luy, Burkhard and Muhle-Goll, Claudia and Scharnagl, Christina and Langosch, Dieter},
  title   = {{Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP}},
  journal = {Scientific reports},
  year    = {2019},
  doi     = {10.1038/s41598-019-41766-1},
  pmid    = {30926830},
  url     = {https://doi.org/10.1038/s41598-019-41766-1}
}

@article{maia2019-30893882,
  author  = {Maia, M. A. and Sousa, E.},
  title   = {{BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease}},
  journal = {Pharmaceuticals (Basel, Switzerland)},
  year    = {2019},
  doi     = {10.3390/ph12010041},
  pmid    = {30893882},
  url     = {https://doi.org/10.3390/ph12010041}
}

@article{shen2019-30791980,
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  title   = {{Iron treatment inhibits Aβ42 deposition in vivo and reduces Aβ42/Aβ40 ratio}},
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  year    = {2019},
  doi     = {10.1016/j.bbrc.2019.01.119},
  pmid    = {30791980},
  url     = {https://doi.org/10.1016/j.bbrc.2019.01.119}
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@article{liu2019-30626721,
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  title   = {{A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor}},
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  year    = {2019},
  doi     = {10.1083/jcb.201806205},
  pmid    = {30626721},
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}

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  title   = {{Small-molecule induction of Aβ-42 peptide production in human cerebral organoids to model Alzheimer's disease associated phenotypes}},
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  title   = {{A new era for understanding amyloid structures and disease}},
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  title   = {{Modeling amyloid beta and tau pathology in human cerebral organoids}},
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@article{reiss2018-29447116,
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  title   = {{Amyloid toxicity in Alzheimer's disease}},
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  year    = {2018},
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@article{sakakibara2018-30055565,
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  title   = {{Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis}},
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  year    = {2018},
  doi     = {10.1186/s12868-018-0446-8},
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@article{cortini2018-30041064,
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  title   = {{Epileptic seizures in autosomal dominant forms of Alzheimer's disease}},
  journal = {Seizure},
  year    = {2018},
  doi     = {10.1016/j.seizure.2018.07.015},
  pmid    = {30041064},
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@article{lee2018-29625119,
  author  = {Lee, M. and Ban, J. J. and Yang, S. and Im, W. and Kim, M.},
  title   = {{The exosome of adipose-derived stem cells reduces β-amyloid pathology and apoptosis of neuronal cells derived from the transgenic mouse model of Alzheimer's disease}},
  journal = {Brain research},
  year    = {2018},
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  pmid    = {29625119},
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@article{fandrich2018-29360284,
  author  = {Fändrich, M. and Nyström, S. and Nilsson, K. P. R. and Böckmann, A. and LeVine, H. and Hammarström, P.},
  title   = {{Amyloid fibril polymorphism: a challenge for molecular imaging and therapy}},
  journal = {Journal of internal medicine},
  year    = {2018},
  doi     = {10.1111/joim.12732},
  pmid    = {29360284},
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}

@article{omtri2018-29337241,
  author  = {Omtri, Rajesh S and Thompson, Kevin J and Tang, Xiaojia and Gali, Chaitanya C and Panzenboeck, Ute and Davidson, Michael W and Kalari, Krishna R and Kandimalla, Karunya K},
  title   = {{Differential Effects of Alzheimer's Disease Aβ40 and 42 on Endocytosis and Intraneuronal Trafficking}},
  journal = {Neuroscience},
  year    = {2018},
  doi     = {10.1016/j.neuroscience.2018.01.003},
  pmid    = {29337241},
  url     = {https://doi.org/10.1016/j.neuroscience.2018.01.003}
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@article{cline2018-29843241,
  author  = {Cline, E. N. and Bicca, M. A. and Viola, K. L. and Klein, W. L.},
  title   = {{The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2018},
  doi     = {10.3233/jad-179941},
  pmid    = {29843241},
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@article{hu2017-29215043,
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  title   = {{β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing}},
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  year    = {2017},
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  title   = {{APP mouse models for Alzheimer's disease preclinical studies}},
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  year    = {2017},
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  pmid    = {28768718},
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@article{chen2017-28713158,
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  title   = {{Amyloid beta: structure, biology and structure-based therapeutic development}},
  journal = {Acta pharmacologica Sinica},
  year    = {2017},
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  pmid    = {28713158},
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@article{ye2017-28701326,
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  title   = {{Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis}},
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  year    = {2017},
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@article{chiti2017-28498720,
  author  = {Chiti, F. and Dobson, C. M.},
  title   = {{Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade}},
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  year    = {2017},
  doi     = {10.1146/annurev-biochem-061516-045115},
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@article{wang2017-28351972,
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  title   = {{ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2017},
  doi     = {10.1073/pnas.1618804114},
  pmid    = {28351972},
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@article{maesako2017-28132667,
  author  = {Maesako, Masato and Horlacher, Jana and Zoltowska, Katarzyna M and Kastanenka, Ksenia V and Kara, Eleanna and Svirsky, Sarah and Keller, Laura J and Li, Xuejing and others},
  title   = {{Pathogenic PS1 phosphorylation at Ser367}},
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  year    = {2017},
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  pmid    = {28132667},
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@article{ricciarelli2017-28093977,
  author  = {Ricciarelli, R. and Fedele, E.},
  title   = {{The Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind}},
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  year    = {2017},
  doi     = {10.2174/1570159x15666170116143743},
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@article{sun2017-27930341,
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  title   = {{Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2017},
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  pmid    = {27930341},
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@article{ni2017-27693181,
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  title   = {{Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease}},
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  year    = {2017},
  doi     = {10.1016/j.jalz.2016.08.006},
  pmid    = {27693181},
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  title   = {{Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes}},
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  year    = {2016},
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  pmid    = {27622770},
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@article{xu2016-27625790,
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  title   = {{Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio}},
  journal = {Cell discovery},
  year    = {2016},
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  pmid    = {27625790},
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@article{walti2016-27469165,
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  title   = {{Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril}},
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  year    = {2016},
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  pmid    = {27469165},
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@article{colvin2016-27355699,
  author  = {Colvin, M. T. and Silvers, R. and Ni, Q. Z. and Can, T. V. and Sergeyev, I. and Rosay, M. and Donovan, K. J. and Michael, B. and others},
  title   = {{Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils}},
  journal = {Journal of the American Chemical Society},
  year    = {2016},
  doi     = {10.1021/jacs.6b05129},
  pmid    = {27355699},
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@article{zoltowska2016-27391800,
  author  = {Zoltowska, Katarzyna Marta and Maesako, Masato and Berezovska, Oksana},
  title   = {{Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation}},
  journal = {Molecular medicine (Cambridge, Mass.)},
  year    = {2016},
  doi     = {10.2119/molmed.2016.00127},
  pmid    = {27391800},
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@article{guo2007-17684098,
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  title   = {{Targeting amyloid-beta in glaucoma treatment}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2007},
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  pmid    = {17684098},
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}

@article{ring2007-17634375,
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  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
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  pmid    = {17634375},
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}

@article{matsui2007-17586478,
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  title   = {{Expression of APP pathway mRNAs and proteins in Alzheimer's disease}},
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  year    = {2007},
  doi     = {10.1016/j.brainres.2007.05.050},
  pmid    = {17586478},
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}

@article{sawaya2007-17468747,
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  title   = {{Atomic structures of amyloid cross-beta spines reveal varied steric zippers}},
  journal = {Nature},
  year    = {2007},
  doi     = {10.1038/nature05695},
  pmid    = {17468747},
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}

@article{walsh2007-17286590,
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  title   = {{A beta oligomers - a decade of discovery}},
  journal = {Journal of neurochemistry},
  year    = {2007},
  doi     = {10.1111/j.1471-4159.2006.04426.x},
  pmid    = {17286590},
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}

@article{wolfe2007-17268504,
  author  = {Wolfe, M. S.},
  title   = {{When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease}},
  journal = {EMBO reports},
  year    = {2007},
  doi     = {10.1038/sj.embor.7400896},
  pmid    = {17268504},
  url     = {https://doi.org/10.1038/sj.embor.7400896}
}

@article{shioi2007-17254019,
  author  = {Shioi, J. and Georgakopoulos, A. and Mehta, P. and Kouchi, Z. and Litterst, C. M. and Baki, L. and Robakis, N. K.},
  title   = {{FAD mutants unable to increase neurotoxic Abeta 42 suggest that mutation effects on neurodegeneration may be independent of effects on Abeta}},
  journal = {Journal of neurochemistry},
  year    = {2007},
  doi     = {10.1111/j.1471-4159.2006.04391.x},
  pmid    = {17254019},
  url     = {https://doi.org/10.1111/j.1471-4159.2006.04391.x}
}

@article{bell2007-17077814,
  author  = {Bell, R. D. and Sagare, A. P. and Friedman, A. E. and Bedi, G. S. and Holtzman, D. M. and Deane, R. and Zlokovic, B. V.},
  title   = {{Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system}},
  journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year    = {2007},
  doi     = {10.1038/sj.jcbfm.9600419},
  pmid    = {17077814},
  url     = {https://doi.org/10.1038/sj.jcbfm.9600419}
}

@article{gimenezllort2007-17055579,
  author  = {Giménez-Llort, L. and Blázquez, G. and Cañete, T. and Johansson, B. and Oddo, S. and Tobeña, A. and LaFerla, F. M. and Fernández-Teruel, A.},
  title   = {{Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid}},
  journal = {Neuroscience and biobehavioral reviews},
  year    = {2007},
  doi     = {10.1016/j.neubiorev.2006.07.007},
  pmid    = {17055579},
  url     = {https://doi.org/10.1016/j.neubiorev.2006.07.007}
}

@article{willem2006-16990514,
  author  = {Willem, M. and Garratt, A. N. and Novak, B. and Citron, M. and Kaufmann, S. and Rittger, A. and DeStrooper, B. and Saftig, P. and others},
  title   = {{Control of peripheral nerve myelination by the beta-secretase BACE1}},
  journal = {Science (New York, N.Y.)},
  year    = {2006},
  doi     = {10.1126/science.1132341},
  pmid    = {16990514},
  url     = {https://doi.org/10.1126/science.1132341}
}

@article{patton2006-16936277,
  author  = {Patton, R. L. and Kalback, W. M. and Esh, C. L. and Kokjohn, T. A. and Van Vickle, G. D. and Luehrs, D. C. and Kuo, Y. M. and Lopez, J. and others},
  title   = {{Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis}},
  journal = {The American journal of pathology},
  year    = {2006},
  doi     = {10.2353/ajpath.2006.060269},
  pmid    = {16936277},
  url     = {https://doi.org/10.2353/ajpath.2006.060269}
}

@article{meyerluehmann2006-16990547,
  author  = {Meyer-Luehmann, M. and Coomaraswamy, J. and Bolmont, T. and Kaeser, S. and Schaefer, C. and Kilger, E. and Neuenschwander, A. and Abramowski, D. and others},
  title   = {{Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host}},
  journal = {Science (New York, N.Y.)},
  year    = {2006},
  doi     = {10.1126/science.1131864},
  pmid    = {16990547},
  url     = {https://doi.org/10.1126/science.1131864}
}

@article{rajendran2006-16837572,
  author  = {Rajendran, L. and Honsho, M. and Zahn, T. R. and Keller, P. and Geiger, K. D. and Verkade, P. and Simons, K.},
  title   = {{Alzheimer's disease beta-amyloid peptides are released in association with exosomes}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0603838103},
  pmid    = {16837572},
  url     = {https://doi.org/10.1073/pnas.0603838103}
}

@article{malaplatearmand2006-16626961,
  author  = {Malaplate-Armand, C. and Florent-Béchard, S. and Youssef, I. and Koziel, V. and Sponne, I. and Kriem, B. and Leininger-Muller, B. and Olivier, J. L. and others},
  title   = {{Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway}},
  journal = {Neurobiology of disease},
  year    = {2006},
  doi     = {10.1016/j.nbd.2006.02.010},
  pmid    = {16626961},
  url     = {https://doi.org/10.1016/j.nbd.2006.02.010}
}

@article{lesne2006-16541076,
  author  = {Lesné, S. and Koh, M. T. and Kotilinek, L. and Kayed, R. and Glabe, C. G. and Yang, A. and Gallagher, M. and Ashe, K. H.},
  title   = {{A specific amyloid-beta protein assembly in the brain impairs memory}},
  journal = {Nature},
  year    = {2006},
  doi     = {10.1038/nature04533},
  pmid    = {16541076},
  url     = {https://doi.org/10.1038/nature04533}
}

@article{tycko2006-16772049,
  author  = {Tycko, Robert},
  title   = {{Molecular structure of amyloid fibrils: insights from solid-state NMR}},
  journal = {Quarterly Reviews of Biophysics},
  year    = {2006},
  doi     = {10.1017/s0033583506004173},
  pmid    = {16772049},
  url     = {https://doi.org/10.1017/s0033583506004173}
}

@article{petkova2006-16401079,
  author  = {Petkova, A. T. and Yau, W. M. and Tycko, R.},
  title   = {{Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils}},
  journal = {Biochemistry},
  year    = {2006},
  doi     = {10.1021/bi051952q},
  pmid    = {16401079},
  url     = {https://doi.org/10.1021/bi051952q}
}

@article{laird2005-16354928,
  author  = {Laird, F. M. and Cai, H. and Savonenko, A. V. and Farah, M. H. and He, K. and Melnikova, T. and Wen, H. and Chiang, H. C. and others},
  title   = {{BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2766-05.2005},
  pmid    = {16354928},
  url     = {https://doi.org/10.1523/jneurosci.2766-05.2005}
}

@article{ko2007-16309826,
  author  = {Ko, S. Y. and Lin, S. C. and Wong, Y. K. and Liu, C. J. and Chang, K. W. and Liu, T. Y.},
  title   = {{Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma}},
  journal = {Cancer letters},
  year    = {2007},
  doi     = {10.1016/j.canlet.2005.10.019},
  pmid    = {16309826},
  url     = {https://doi.org/10.1016/j.canlet.2005.10.019}
}

@article{klunk2005-16291932,
  author  = {Klunk, W. E. and Lopresti, B. J. and Ikonomovic, M. D. and Lefterov, I. M. and Koldamova, R. P. and Abrahamson, E. E. and Debnath, M. L. and Holt, D. P. and others},
  title   = {{Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.2990-05.2005},
  pmid    = {16291932},
  url     = {https://doi.org/10.1523/jneurosci.2990-05.2005}
}

@article{andersen2005-16174740,
  author  = {Andersen, O. M. and Reiche, J. and Schmidt, V. and Gotthardt, M. and Spoelgen, R. and Behlke, J. and von Arnim, C. A. and Breiderhoff, T. and others},
  title   = {{Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0503689102},
  pmid    = {16174740},
  url     = {https://doi.org/10.1073/pnas.0503689102}
}

@article{barghorn2005-16135089,
  author  = {Barghorn, S. and Nimmrich, V. and Striebinger, A. and Krantz, C. and Keller, P. and Janson, B. and Bahr, M. and Schmidt, M. and others},
  title   = {{Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2005},
  doi     = {10.1111/j.1471-4159.2005.03407.x},
  pmid    = {16135089},
  url     = {https://doi.org/10.1111/j.1471-4159.2005.03407.x}
}

@article{quist2005-16020533,
  author  = {Quist, A. and Doudevski, I. and Lin, H. and Azimova, R. and Ng, D. and Frangione, B. and Kagan, B. and Ghiso, J. and others},
  title   = {{Amyloid ion channels: a common structural link for protein-misfolding disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0502066102},
  pmid    = {16020533},
  url     = {https://doi.org/10.1073/pnas.0502066102}
}

@article{vanes2005-15959515,
  author  = {van Es, J. H. and van Gijn, M. E. and Riccio, O. and van den Born, M. and Vooijs, M. and Begthel, H. and Cozijnsen, M. and Robine, S. and others},
  title   = {{Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells}},
  journal = {Nature},
  year    = {2005},
  doi     = {10.1038/nature03659},
  pmid    = {15959515},
  url     = {https://doi.org/10.1038/nature03659}
}

@article{williams2005-15883377,
  author  = {Williams, A. D. and Sega, M. and Chen, M. and Kheterpal, I. and Geva, M. and Berthelier, V. and Kaleta, D. T. and Cook, K. D. and others},
  title   = {{Structural properties of Abeta protofibrils stabilized by a small molecule}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0408582102},
  pmid    = {15883377},
  url     = {https://doi.org/10.1073/pnas.0408582102}
}

@article{caccamo2005-15708439,
  author  = {Caccamo, A. and Oddo, S. and Sugarman, M. C. and Akbari, Y. and LaFerla, F. M.},
  title   = {{Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders}},
  journal = {Neurobiology of aging},
  year    = {2005},
  doi     = {10.1016/j.neurobiolaging.2004.06.013},
  pmid    = {15708439},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.06.013}
}

@article{ishigami2005-15704193,
  author  = {Ishigami, A. and Ohsawa, T. and Hiratsuka, M. and Taguchi, H. and Kobayashi, S. and Saito, Y. and Murayama, S. and Asaga, H. and others},
  title   = {{Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease}},
  journal = {Journal of neuroscience research},
  year    = {2005},
  doi     = {10.1002/jnr.20431},
  pmid    = {15704193},
  url     = {https://doi.org/10.1002/jnr.20431}
}

@article{stokin2005-15731448,
  author  = {Stokin, G. B. and Lillo, C. and Falzone, T. L. and Brusch, R. G. and Rockenstein, E. and Mount, S. L. and Raman, R. and Davies, P. and others},
  title   = {{Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease}},
  journal = {Science (New York, N.Y.)},
  year    = {2005},
  doi     = {10.1126/science.1105681},
  pmid    = {15731448},
  url     = {https://doi.org/10.1126/science.1105681}
}

@article{walker2005-15663477,
  author  = {Walker, E. S. and Martinez, M. and Brunkan, A. L. and Goate, A.},
  title   = {{Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios}},
  journal = {Journal of neurochemistry},
  year    = {2005},
  doi     = {10.1111/j.1471-4159.2004.02858.x},
  pmid    = {15663477},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02858.x}
}

@article{krebs2005-15629655,
  author  = {Krebs, M. R. and Bromley, E. H. and Donald, A. M.},
  title   = {{The binding of thioflavin-T to amyloid fibrils: localisation and implications}},
  journal = {Journal of structural biology},
  year    = {2005},
  doi     = {10.1016/j.jsb.2004.08.002},
  pmid    = {15629655},
  url     = {https://doi.org/10.1016/j.jsb.2004.08.002}
}

@article{wirths2004-15485483,
  author  = {Wirths, O. and Multhaup, G. and Bayer, T. A.},
  title   = {{A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide--the first step of a fatal cascade}},
  journal = {Journal of neurochemistry},
  year    = {2004},
  doi     = {10.1111/j.1471-4159.2004.02737.x},
  pmid    = {15485483},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02737.x}
}

@article{cataldo2004-15465622,
  author  = {Cataldo, A. M. and Petanceska, S. and Terio, N. B. and Peterhoff, C. M. and Durham, R. and Mercken, M. and Mehta, P. D. and Buxbaum, J. and others},
  title   = {{Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome}},
  journal = {Neurobiology of aging},
  year    = {2004},
  doi     = {10.1016/j.neurobiolaging.2004.02.027},
  pmid    = {15465622},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.02.027}
}

@article{gylys2004-15509549,
  author  = {Gylys, K. H. and Fein, J. A. and Yang, F. and Wiley, D. J. and Miller, C. A. and Cole, G. M.},
  title   = {{Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence}},
  journal = {The American journal of pathology},
  year    = {2004},
  doi     = {10.1016/s0002-9440(10)63436-0},
  pmid    = {15509549},
  url     = {https://doi.org/10.1016/s0002-9440(10)63436-0}
}

@article{lacor2004-15537891,
  author  = {Lacor, P. N. and Buniel, M. C. and Chang, L. and Fernandez, S. J. and Gong, Y. and Viola, K. L. and Lambert, M. P. and Velasco, P. T. and others},
  title   = {{Synaptic targeting by Alzheimer's-related amyloid beta oligomers}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2004},
  doi     = {10.1523/jneurosci.3432-04.2004},
  pmid    = {15537891},
  url     = {https://doi.org/10.1523/jneurosci.3432-04.2004}
}

@article{grigorenko2004-15469912,
  author  = {Grigorenko, Anastasia P. and Moliaka, Yuri K. and Soto, Martha C. and Mello, Craig C. and Rogaev, Evgeny Ivanovich},
  title   = {{The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {2004},
  doi     = {10.1073/pnas.0406462101},
  pmid    = {15469912},
  url     = {https://doi.org/10.1073/pnas.0406462101}
}

@article{citron2004-15322526,
  author  = {Citron, M.},
  title   = {{Strategies for disease modification in Alzheimer's disease}},
  journal = {Nature reviews. Neuroscience},
  year    = {2004},
  doi     = {10.1038/nrn1495},
  pmid    = {15322526},
  url     = {https://doi.org/10.1038/nrn1495}
}

@article{nilsson2004-15283924,
  author  = {Nilsson, M. R.},
  title   = {{Techniques to study amyloid fibril formation in vitro}},
  journal = {Methods (San Diego, Calif.)},
  year    = {2004},
  doi     = {10.1016/j.ymeth.2004.03.012},
  pmid    = {15283924},
  url     = {https://doi.org/10.1016/j.ymeth.2004.03.012}
}

@article{deane2004-15294142,
  author  = {Deane, R. and Wu, Z. and Sagare, A. and Davis, J. and Du Yan, S. and Hamm, K. and Xu, F. and Parisi, M. and others},
  title   = {{LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms}},
  journal = {Neuron},
  year    = {2004},
  doi     = {10.1016/j.neuron.2004.07.017},
  pmid    = {15294142},
  url     = {https://doi.org/10.1016/j.neuron.2004.07.017}
}

@article{liao2004-15220353,
  author  = {Liao, L. and Cheng, D. and Wang, J. and Duong, D. M. and Losik, T. G. and Gearing, M. and Rees, H. D. and Lah, J. J. and others},
  title   = {{Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection}},
  journal = {The Journal of biological chemistry},
  year    = {2004},
  doi     = {10.1074/jbc.m403672200},
  pmid    = {15220353},
  url     = {https://doi.org/10.1074/jbc.m403672200}
}

@article{allinson2004-15182369,
  author  = {Allinson, T. M. and Parkin, E. T. and Condon, T. P. and Schwager, S. L. and Sturrock, E. D. and Turner, A. J. and Hooper, N. M.},
  title   = {{The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein}},
  journal = {European journal of biochemistry},
  year    = {2004},
  doi     = {10.1111/j.1432-1033.2004.04184.x},
  pmid    = {15182369},
  url     = {https://doi.org/10.1111/j.1432-1033.2004.04184.x}
}

@article{takahashi2004-15071107,
  author  = {Takahashi, Reisuke H. and Almeida, Cláudia Guimas and Kearney, Patrick F. and Yu, Fangmin and Lin, Michael T. S. and Milner, Teresa A. and Gouras, Gunnar K.},
  title   = {{Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain}},
  journal = {Journal of Neuroscience},
  year    = {2004},
  doi     = {10.1523/jneurosci.5167-03.2004},
  pmid    = {15071107},
  url     = {https://doi.org/10.1523/jneurosci.5167-03.2004}
}

@article{mathis2004-15134570,
  author  = {Mathis, C. A. and Wang, Y. and Klunk, W. E.},
  title   = {{Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain}},
  journal = {Current pharmaceutical design},
  year    = {2004},
  doi     = {10.2174/1381612043384772},
  pmid    = {15134570},
  url     = {https://doi.org/10.2174/1381612043384772}
}

@article{duckert2004-14985543,
  author  = {Duckert, P. and Brunak, S. and Blom, N.},
  title   = {{Prediction of proprotein convertase cleavage sites}},
  journal = {Protein engineering, design \& selection : PEDS},
  year    = {2004},
  doi     = {10.1093/protein/gzh013},
  pmid    = {14985543},
  url     = {https://doi.org/10.1093/protein/gzh013}
}

@article{oddo2003-14643377,
  author  = {Oddo, S. and Caccamo, A. and Kitazawa, M. and Tseng, B. P. and LaFerla, F. M.},
  title   = {{Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2003},
  doi     = {10.1016/j.neurobiolaging.2003.08.012},
  pmid    = {14643377},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2003.08.012}
}

@article{jankowsky2004-14645205,
  author  = {Jankowsky, J. L. and Fadale, D. J. and Anderson, J. and Xu, G. M. and Gonzales, V. and Jenkins, N. A. and Copeland, N. G. and Lee, M. K. and others},
  title   = {{Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase}},
  journal = {Human molecular genetics},
  year    = {2004},
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  title   = {{Nicastrin binds to membrane-tethered Notch}},
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@article{kojro2001-11309494,
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  title   = {{A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease}},
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  title   = {{Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model}},
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