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Home › Research › Topics › precursor

precursor

1,346 studies tagged precursor, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,346 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Alzheimer's research & therapy 2023-09-20 Treatments

    Additionally, our results indicate that AD subjects carrying APOE ε4 are more responsive to the neuroprotective effects of physical activity.

  2. Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Antioxidants (Basel, Switzerland) 2023-08-17 Disease mechanisms

    Alzheimer's disease (AD) is a brain disorder that progressively undermines memory and thinking skills by affecting the hippocampus and entorhinal cortex.

  3. Improving the Bioavailability and Efficacy of Coenzyme Q10 on Alzheimer's Disease Through the Arginine Based Proniosomes

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of pharmaceutical sciences 2023-07-26 Tau biomarkers

    Coenzyme Q10 (CoQ10) is a fat-soluble vitamin-with a benzoquinone-like structure.

  4. Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Brain : a journal of neurology 2023-07-01 Biomarkers

    Heterogeneity in progression to Alzheimer's disease (AD) poses challenges for both clinical prognosis and clinical trial implementation.

  5. Clonal hematopoiesis is associated with protection from Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 80 out of 100. Nature medicine 2023-06-15 Inflammation and the immune system

    Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant expansion of mutated hematopoietic stem cells.

  6. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Aging cell 2023-06-08 Risk genes beyond APOE

    Although pathogenic variants in PSEN1 leading to autosomal-dominant Alzheimer disease (ADAD) are highly penetrant, substantial interindividual variability in the rates of cognitive decline and biomarker change are observed in ADAD.

  7. Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Alzheimer's & Dementia 2023-06-01 Genetics

    Our results highlight the efficacy of founder populations for AD genetic studies.

  8. Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. Nature 2023-05-31 How common it is

    The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly with age, but why age constitutes the main risk factor is still poorly understood.

  9. Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature Medicine 2023-05-15 Genetics

    We characterized the world's second case with ascertained extreme resilience to autosomal dominant Alzheimer's disease (ADAD).

  10. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Nature communications 2023-04-21 Genetics

    Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the amyloid cascade, lipid metabolism, and neuroimmune modulation.

  11. MicroRNA expression in extracellular vesicles as a novel blood-based biomarker for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2023-04-18 Mild cognitive impairment

    Brain cell-derived small extracellular vesicles (sEVs) in blood offer unique cellular and molecular information related to the onset and progression of Alzheimer's disease (AD).

  12. Blood β-synuclein is related to amyloid PET positivity in memory clinic patients

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2023-04-13 Biomarkers

    Plasma β-synuclein demonstrated discriminative properties for Aβ PET positive and negative subjects.

  13. Accelerated Brain Volume Loss Caused by Anti-β-Amyloid Drugs: A Systematic Review and Meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 78 out of 100. Neurology 2023-03-27 Treatments

    These findings reveal the potential for anti-Aβ therapies to compromise long-term brain health by accelerating brain atrophy and provide new insight into the adverse impact of ARIA.

  14. Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 73 out of 100. JAMA 2023-02-21 Genetics

    In this exploratory analysis, the APOE ε3[R145C] missense variant was associated with an increased risk of AD among individuals of African ancestry with the ε3/ε4 genotype.

  15. ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular psychiatry 2023-02-01 Biomarkers

    Amyloid-β (Aβ) deposition in the brain parenchyma is one of the pathological hallmarks of Alzheimer disease (AD).

  16. Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Nature immunology 2023-01-19 TREM2 and immune genetics

    The TREM2-DAP12 receptor complex sustains microglia functions.

  17. Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Brain : a journal of neurology 2023-01-01 Long-term cohort studies

    Higher vascular disease burden increases the likelihood of developing dementia, including Alzheimer's disease.

  18. Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Alzheimer's & Dementia 2022-12-20 Genetics

    Our ancestry-aware regression approach showed that AA individuals have a lower risk of AD if they inherited African ancestry admixture block at the 17p13.2 locus.

  19. INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2022-12-16 TREM2 and immune genetics

    A non-coding variant (rs35349669) in INPP5D increases the risk for Alzheimer's disease (AD), and elevated INPP5D expression is associated with increased plaque deposition.

  20. Therapeutic anti-amyloid β antibodies cause neuronal disturbances

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2022-12-14 Drug development

    Recent published clinical trial safety data showed that 41% of Alzheimer patients experienced amyloid-related imaging abnormalities (ARIA), marks of microhemorrhages and edema in the brain, following administration of Biogen's Aduhelm/aducanumab (amino acids 3-7 of the Aβ peptide).

  21. Association of MRI Indices of Glymphatic System With Amyloid Deposition and Cognition in Mild Cognitive Impairment and Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Neurology 2022-12-12 Genetics

    Our study indicates that changes in PVS-related MRI parameters occur in MCI and AD, possibly due to impairment of the glymphatic system.

  22. Dietary fish oil increases catalase activity in patients with probable Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Nutricion hospitalaria 2022-12-01 Treatments

    carbonyl groups in proteins and hydroperoxides in plasma have similar values in both treatment groups at the beginning of the study.

  23. The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Bioorganic chemistry 2022-11-25 Inflammation and the immune system

    Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition and tau hyperphosphorylation, is the most common dementia with uncertain etiology.

  24. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. Nature genetics 2022-11-21 Caregiving

    Alzheimer's disease (AD), the leading cause of dementia, has an estimated heritability of approximately 70% 1 .

  25. Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. JAMA network open 2022-11-01 Tau biomarkers

    Heterozygosity of the KL-VS haplotype has been associated with reduced amyloid and tau burden.

  26. The Link between Oxidative Stress, Mitochondrial Dysfunction and Neuroinflammation in the Pathophysiology of Alzheimer's Disease: Therapeutic Implications and Future Perspectives

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Antioxidants (Basel, Switzerland) 2022-10-31 Caregiving

    Alzheimer's disease (AD), the most common form of dementia, has increasing incidence, increasing mortality rates, and poses a huge burden on healthcare.

  27. Caspase-1 inhibition improves cognition without significantly altering amyloid and inflammation in aged Alzheimer disease mice

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Cell death & disease 2022-10-11 Biomarkers

    Human genetic and animal model studies indicate that brain microglial inflammation is a primary driver of cognitive impairment in Alzheimer Disease (AD).

  28. Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Brain : a journal of neurology 2022-10-01 Biomarkers

    The extent to which the pathophysiology of autosomal dominant Alzheimer's disease corresponds to the pathophysiology of 'sporadic' late onset Alzheimer's disease is unknown, thus limiting the extrapolation of study findings and clinical trial results in autosomal dominant Alzheimer's disease to late onset Alzheimer's disease.

  29. Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neurobiology of disease 2022-09-30 Long-term cohort studies

    The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and neurofibrillary tangles (AD neuropathologic changes, or ADNC).

  30. DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature communications 2022-09-24 Inflammation and the immune system

    Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of tau in the neocortex.

  31. Role of Microglia and Astrocytes in Alzheimer's Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Cells 2022-09-01 Inflammation and the immune system

    Alzheimer's disease (AD) is the most common form of dementia worldwide, with a complex, poorly understood pathogenesis.

  32. Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. EBioMedicine 2022-08-27 Tau biomarkers

    The apolipoprotein E (APOE)ε4 allele is the strongest genetic risk factor for late-onset AD and is associated with aberrant cerebrospinal fluid levels (CSF) of total tau (t-tau), phosphorylated tau (p-tau), and amyloid-β (Aβ).

  33. Association of Microglial Activation With Spontaneous ARIA-E and CSF Levels of Anti-Aβ Autoantibodies

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Neurology 2022-08-08 Brain scans and imaging

    ARIA-E can also occur spontaneously in cerebral amyloid angiopathy-related inflammation (CAA-ri), a rare autoimmune encephalopathy associated with increased CSF levels of anti-Aβ autoantibodies.

  34. Association of APOE Genotypes and Chronic Traumatic Encephalopathy

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA neurology 2022-08-01 Disparities

    Limited evidence suggests that the APOEε4 allele may confer risk for CTE, but previous studies were small with limited scope.

  35. Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Brain : a journal of neurology 2022-08-01 Disparities

    Accumulating data suggest that cerebrovascular disease contributes to Alzheimer's disease pathophysiology and progression toward dementia.

  36. Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. JAMA neurology 2022-07-01 Genetics

    In this genetic association study, a novel variant associated with AD was identified: R251G always coinherited with ε4 on the APOE gene, which mitigates the ε4-associated AD risk.

  37. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Cell reports 2022-06-01 TREM2 and immune genetics

    Microglia are strongly implicated in the development and progression of Alzheimer's disease (AD), yet their impact on pathology and lifespan remains unclear.

  38. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease risk

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. PloS one 2022-05-26 Tau biomarkers

    Two genetic variants in strong linkage disequilibrium (rs9536314 and rs9527025) in the Klotho (KL) gene, encoding a transmembrane protein, implicated in longevity and associated with brain resilience during normal aging, were recently shown to be associated with Alzheimer disease (AD) risk in cognitively normal participants who are APOE ε4 carriers.

  39. Aducanumab-Related Amyloid-Related Imaging Abnormalities: Paean or Lament?

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Clinical nuclear medicine 2022-04-22 Drug development

    We believe that the amyloid-PET scans, perceived as showing decreasing amyloid deposits, are an expression of increased cerebral cell death due to aducanumab treatment, so that with time one should instead expect a worsening and not an improvement in the treated patients' condition.

  40. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Neuron 2022-03-16 Risk factors

    The ε4 allele of the apolipoprotein E gene (APOE4) is a strong genetic risk factor for Alzheimer's disease (AD) and several other neurodegenerative conditions, including Lewy body dementia (LBD).

  41. Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurobiology of disease 2022-03-02 Inflammation and the immune system

    Microglia have been identified as key players in Alzheimer's disease pathogenesis, and other neurodegenerative diseases.

  42. Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Molecular neurodegeneration 2022-02-02 Biomarkers

    This study reveals an important role of astrocytic apoE3 and apoE4 on the deposition and accumulation of Aβ plaques as well as on certain Aβ-associated downstream effects.

  43. Association of β-Amyloid Accumulation With Executive Function in Adults With Unimpaired Cognition

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Neurology 2022-01-12 Tau biomarkers

    The neuropathologic changes underlying Alzheimer disease (AD) start before overt cognitive symptoms arise, but it is not well-known how they relate to the first subtle cognitive changes.

  44. Long-term Benefits and Harms Associated With Genetic Cholesteryl Ester Transfer Protein Deficiency in the General Population

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. JAMA cardiology 2022-01-01 Treatments

    Of 102 607 individuals in the study, 56 559 (55%) were women (median age, 58 years [IQR, 47-67 years]).

  45. Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in pharmacology 2021-12-02 TREM2 and immune genetics

    Alzheimer's disease (AD) is the most common cause of dementia, yet there is no cure or diagnostics available prior to the onset of clinical symptoms.

  46. Implications of Phosphoinositide 3-Kinase-Akt (PI3K-Akt) Pathway in the Pathogenesis of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular neurobiology 2021-10-26 Disease mechanisms

    Alzheimer's disease (AD) is the foremost type of dementia that afflicts considerable morbidity and mortality in aged population.

  47. Multi-tissue proteomics identifies molecular signatures for sporadic and genetically defined Alzheimer disease cases

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. Research Square 2021-10-21 Tau biomarkers

    Alzheimer disease (AD) is a heterogeneous disease with many genes are associated with AD risk.

  48. Association of peripheral blood DNA methylation level with Alzheimer's disease progression

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Clinical epigenetics 2021-10-15 Long-term cohort studies

    Identifying biomarkers associated with Alzheimer's disease (AD) progression may enable patient enrichment and improve clinical trial designs.

  49. Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Frontiers in aging neuroscience 2021-09-30 Digital health tools

    Strikingly gene-expression, network-based analysis and cell type deconvolution approaches revealed a consistent immune signature in the brain and blood of female AD patients that was absent in males.

  50. Spontaneous ARIA-like Events in Cerebral Amyloid Angiopathy-Related Inflammation: A Multicenter Prospective Longitudinal Cohort Study

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Neurology 2021-09-16 Genetics

    These results from the largest longitudinal cohort registry of patients with CAA-ri support the transient and potentially relapsing inflammatory nature of the clinical-radiologic acute manifestations of the disease and the effectiveness of slow oral tapering off after IV corticosteroid pulse therapy in preventing recurrences.

From across this tag

10 of the 1,344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts