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Home › Research › Topics › precursor

precursor

1,346 studies tagged precursor, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,346 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Genomics 2009-02-03 Genetics

    The epsilon4 allele of APOE is a well-characterized genetic risk factor for late-onset Alzheimer disease (LOAD).

  2. The effects of amyloid precursor protein on postsynaptic composition and activity

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2009-01-21 Risk genes beyond APOE

    The amyloid precursor protein (APP) is cleaved to produce the Alzheimer disease-associated peptide Abeta, but the normal functions of uncleaved APP in the brain are unknown.

  3. Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2009-01-17 Caregiving

    Alzheimer's disease is a major cause of dementia in humans.

  4. Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Neurochemical research 2009-01-04 Risk genes beyond APOE

    Chronic cerebral hypoperfusion (CCH) increases the risk of Alzheimer disease (AD) through several biologically plausible pathways, but the relationship between CCH and the development of AD remains uncertain.

  5. Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. American journal of human genetics 2009-01-01 Genetics

    Only Apolipoprotein E polymorphisms have been consistently associated with the risk of late-onset Alzheimer disease (LOAD), but they represent only a minority of the underlying genetic effect.

  6. [(11)C]PIB-amyloid binding and levels of Abeta40 and Abeta42 in postmortem brain tissue from Alzheimer patients

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurochemistry international 2008-12-30 Brain scans and imaging

    beta-Amyloid (Abeta) deposits are one of the major histopathological hallmarks of Alzheimer's disease (AD).

  7. DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neurobiology of disease 2008-12-16 Brain scans and imaging

    Cholesterol and docosahexenoic acid (DHA) may affect degenerative processes in Alzheimer's Disease (AD) by influencing Abeta metabolism indirectly via the vasculature.

  8. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2008-12-12 Risk genes beyond APOE

    Alzheimer disease beta-amyloid (Abeta) peptides are generated via sequential proteolysis of amyloid precursor protein (APP) by BACE1 and gamma-secretase.

  9. Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. EMBO reports 2008-12-05 Risk genes beyond APOE

    Amyloid beta-peptide (Abeta) accumulation leads to neurodegeneration and Alzheimer disease; however, amyloid metabolism is a dynamic process and enzymic mechanisms exist for Abeta removal.

  10. Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2008-12-02 Risk genes beyond APOE

    Mitochondrial dysfunction is a prominent feature of Alzheimer disease but the underlying mechanism is unclear.

  11. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Annals of the New York Academy of Sciences 2008-12-01 Mild cognitive impairment

    One of the main features of Alzheimer's disease (AD) is the severe reduction of the cerebral metabolic rate for glucose (CMRglc).

  12. Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Brain : a journal of neurology 2008-11-28 How common it is

    Although beta-amyloid (Abeta) plaques are a primary diagnostic criterion for Alzheimer's disease, this pathology is commonly observed in the brains of non-demented older individuals.

  13. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The Journal of clinical investigation 2008-11-13 Genetics

    Neurotoxic amyloid beta peptide (Abeta) accumulates in the brains of individuals with Alzheimer disease (AD).

  14. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 2008-11-05 Risk genes beyond APOE

    MicroRNAs (miRNAs) are key regulatory RNAs known to repress mRNA translation through recognition of specific binding sites located mainly in their 3'-untranslated region (UTR).

  15. Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Archives of neurology 2008-11-01 Caregiving

    Uptake of carbon 11-labeled Pittsburgh Compound B ([(11)C]PiB) was measured for participants assessed between August 15, 2003, and January 8, 2008, at the Washington University Alzheimer's Disease Research Center and diagnosed either as nondemented (n = 161) or with dementia of the Alzheimer type (n = 37).

  16. Evidence for altered LRP/RAGE expression in Alzheimer lesion pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current Alzheimer research 2008-10-01 Disease mechanisms

    There is significant evidence to suggest that a damaged or dysfunctional blood-brain barrier (BBB) may contribute to the pathogenesis of Alzheimer's disease (AD) lesions.

  17. Selective induction of calcineurin activity and signaling by oligomeric amyloid beta

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Aging cell 2008-09-08 Disease mechanisms

    Alzheimer's disease (AD) is a terminal age-associated dementia characterized by early synaptic dysfunction and late neurodegeneration.

  18. Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neurochemistry 2008-09-02 Risk genes beyond APOE

    Amyloid precursor protein (APP) mis-processing and aberrant tau hyperphosphorylation are causally related to the pathogenesis and neurodegenerative processes that characterize Alzheimer's disease (AD).

  19. Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytes

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of neuropathology and experimental neurology 2008-09-01 Genetics

    Apolipoprotein E (apoE) plays a role in the pathogenesis of Alzheimer disease (AD).

  20. Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of cellular and molecular medicine 2008-08-21 Mild cognitive impairment

    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in multiple cognitive domains.

  21. Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Journal of Neuroscience 2008-08-13 Inflammation and the immune system

    Early microglial accumulation in Alzheimer's disease (AD) delays disease progression by promoting clearance of beta-amyloid (Abeta) before formation of senile plaques.

  22. Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Archives of neurology 2008-08-01 Risk genes beyond APOE

    We used a sensitive and specific beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) assay to determine the relationship between BACE1 activity in cerebrospinal fluid (CSF) and markers of APP metabolism and axonal degeneration in early and late stages of Alzheimer disease (AD).

  23. Amyloid precursor protein trafficking, processing, and function

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The Journal of biological chemistry 2008-07-23 Risk genes beyond APOE

    Intracellular trafficking and proteolytic processing of amyloid precursor protein (APP) have been the focus of numerous investigations over the past two decades.

  24. The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2008-07-23 Risk genes beyond APOE

    Amyloid plaques, composed of the amyloid beta-protein (Abeta), are hallmark neuropathological lesions in Alzheimer disease (AD) brain.

  25. The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Progress in neurobiology 2008-07-07 Risk genes beyond APOE

    Since the discovery of the amyloid precursor protein (APP) in 1987, extensive research has been conducted analyzing the APP-derived beta-amyloid (Abeta) which is found in massive quantities in senile plaques of Alzheimer disease (AD) patients.

  26. Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neurobiology of aging 2008-06-30 Biomarkers

    Astrocyte pathology occurs in association with Alzheimer's disease (AD) and in brain ageing, but is poorly characterised.

  27. Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Nature Medicine 2008-06-22 Disease mechanisms

    Researchers extracted soluble amyloid-beta protein oligomers directly from the cerebral cortex of subjects with Alzheimer's disease to study their impact.

  28. Amyloid-beta deposits lead to retinal degeneration in a mouse model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Investigative ophthalmology & visual science 2008-06-19 Risk genes beyond APOE

    Retinas of transgenic mice harboring a mutant presenilin (PS1) and a mutant APP gene were processed for TUNEL and immunohistochemistry with antibodies against APP, amyloid-beta, monocyte chemotactic protein (MCP)-1, and F4/80.

  29. Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Nature medicine 2008-06-01 Risk genes beyond APOE

    Alzheimer's disease is the most common dementia and is pathologically characterized by deposition of amyloid-beta peptide (Abeta) into beta-amyloid plaques, neuronal injury and low-level, chronic activation of brain immunity.

  30. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. The Journal of clinical investigation 2008-06-01 Risk genes beyond APOE

    Autophagy is the principal cellular pathway for degradation of long-lived proteins and organelles and regulates cell fate in response to stress.

  31. APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. BMC neurology 2008-04-16 Brain tissue and pathology

    The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway.

  32. APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Neurology 2008-04-09 Genetics

    APOE epsilon 4 may influence rate of cognitive decline most significantly in the earliest stages of Alzheimer disease.

  33. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of neuroinflammation 2008-04-09 Inflammation and the immune system

    Inflammation is associated with Abeta pathology in Alzheimer's disease (AD) and transgenic AD models.

  34. Impaired insulin secretion increases the risk of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 2008-04-09 Genetics

    In this longitudinal study, impaired acute insulin response at midlife was associated with an increased risk of Alzheimer disease (AD) up to 35 years later suggesting a causal link between insulin metabolism and the pathogenesis of AD.

  35. Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Neurology 2008-04-09 Brain scans and imaging

    Plasma A beta levels are affected by age and by systemic and CNS vascular risk factors.

  36. Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of neuropathology and experimental neurology 2008-04-01 Genetics

    There is increasing evidence for blood-brain barrier (BBB) compromise in Alzheimer disease (AD).

  37. Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Archives of neurology 2008-04-01 Risk genes beyond APOE

    A majority of mutations within the beta-amyloid region of the amyloid precursor protein (APP) gene cause inherited forms of intracerebral hemorrhage.

  38. Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain pathology (Zurich, Switzerland) 2008-04-01 Brain tissue and pathology

    Alzheimer's disease is the commonest dementia.

  39. Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Journal of biological chemistry 2008-02-28 Risk genes beyond APOE

    The major molecular risk factor for Alzheimer disease so far identified is the amyloidogenic peptide Abeta(42).

  40. The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of neuroinflammation 2008-02-26 Inflammation and the immune system

    Elevation of the proinflammatory cytokine Interleukin-1 (IL-1) is an integral part of the local tissue reaction to central nervous system (CNS) insult.

  41. Apolipoprotein E epsilon4 magnifies lifestyle risks for dementia: a population-based study

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Journal of cellular and molecular medicine 2008-02-08 Prevention and risk

    The risk of dementia and Alzheimer's disease (AD) probably results from an interaction between genetic and environmental factors.

  42. n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The American journal of clinical nutrition 2008-02-01 Genetics

    These data are evidence of a gene x environment interaction for cognitive aging.

  43. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. The Journal of clinical investigation 2008-02-01 Genetics

    APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD).

  44. Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Free radical research 2008-02-01 Mild cognitive impairment

    There is a great interest in the relationship between Mild Cognitive Impairment (MCI) and the progression to Alzheimer's disease (AD).

  45. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Nature 2008-02-01 Inflammation and the immune system

    Senile plaques accumulate over the course of decades in the brains of patients with Alzheimer's disease.

  46. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of cellular and molecular medicine 2008-01-19 Risk genes beyond APOE

    Down-regulation of protein phosphatase 2A (PP2A) is thought to play a critical role in tau hyperphosphorylation in Alzheimer's disease (AD).

  47. Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The Journal of biological chemistry 2008-01-16 Risk genes beyond APOE

    The beta-amyloid peptide (Abeta) is the major constituent of the amyloid core of senile plaques found in the brain of patients with Alzheimer disease.

  48. Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson's disease patients

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Acta neuropathologica 2008-01-08 Caregiving

    Amyloid-beta (Abeta) peptide pathology in Alzheimer's disease (AD) comprises extracellular plaques and cerebral amyloid angiopathy (CAA).

  49. Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurobiology of disease 2008-01-05 Mild cognitive impairment

    Numerous investigations point to the importance of oxidative imbalance in mediating AD pathogenesis.

  50. Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Archives of neurology 2008-01-01 Genetics

    These data suggest that having both diabetes and APOE epsilon4 increases the risk of dementia, especially for AD and mixed AD.

From across this tag

10 of the 1,344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts