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Home › Research › Topic

Plasma and spinal-fluid biomarkers

1,573 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Considerations and code for partial volume correcting [ 18 F]-AV-1451 tau PET data

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Data in brief 2017-10-16 Brain scans and imaging

    [ 18 F]-AV-1451 is a leading tracer used with positron emission tomography (PET) to quantify tau pathology.

  2. Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. NeuroImage. Clinical 2017-09-25 Brain scans and imaging

    The relationships between β-amyloid (Aβ), tau and neurodegeneration within Alzheimer's Disease pathogenesis are not fully understood.

  3. 18 F-AV-1451 and CSF T-tau and P-tau as biomarkers in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. EMBO molecular medicine 2017-09-01 Brain scans and imaging

    To elucidate the relationship between cerebrospinal fluid (CSF) total-tau (T-tau) and phosphorylated tau (P-tau) with the tau PET ligand 18 F-AV-1451 in Alzheimer's disease (AD), we examined 30 cognitively healthy elderly (15 with preclinical AD), 14 prodromal AD, and 39 AD dementia patients.

  4. The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neurology, neurosurgery, and psychiatry 2017-08-26 Drug development

    Cerebral amyloid angiopathy (CAA) has never been more relevant.

  5. Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Lancet. Neurology 2017-07-11 Costs and economics

    The diagnosis of Alzheimer's disease can be improved by the use of biological measures.

  6. Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Annals of neurology 2017-04-06 Brain scans and imaging

    Our study identified a synergistic effect of amyloid and tau deposits and demonstrated, for the first time, in normal elderly its link to AD-like hypometabolism and to AD-like memory decline.

  7. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain : a journal of neurology 2017-03-01 Brain scans and imaging

    Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed of conformers (i.e. strains) unique to each illness.

  8. Sleep Deprivation Induced Plasma Amyloid-β Transport Disturbance in Healthy Young Adults

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01 Biomarkers

    Sleep deprivation can lead to an elevation of plasma Aβ40 and decrease of the Aβ42/Aβ40 ratio.

  9. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-10-15 Down syndrome and Alzheimer's

    These early increases in Aβ 1-42 , P-T181-tau, and P-S396-tau in individuals with DS may provide a basis for early intervention as targeted treatments become available.

  10. Florbetapir-PET to diagnose cerebral amyloid angiopathy: A prospective study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurology 2016-09-07 Brain scans and imaging

    The CAA and HTN-ICH groups had similar age (66.9 vs 67.1), sex, and leukoaraiosis volumes (31 vs 30 mL, all p > 0.8).

  11. A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Belgium

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2016-08-10 Tau biomarkers

    During the past ten years, over 5,000 cerebrospinal fluid (CSF) samples were analyzed at the Reference Center for Biological Markers of Dementia (BIODEM), UAntwerp, for core Alzheimer's disease (AD) CSF biomarkers: amyloid-β peptide of 42 amino acids (Aβ1-42), total tau protein (T-tau), and tau phosphorylated at threonine 181 (P-tau181P).

  12. Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Annals of neurology 2016-06-01 Tau biomarkers

    We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β.

  13. Clinical use of amyloid-positron emission tomography neuroimaging: Practical and bioethical considerations

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2015-07-26 Brain scans and imaging

    Until recently, estimation of β-amyloid plaque density as a key element for identifying Alzheimer's disease (AD) pathology as the cause of cognitive impairment was only possible at autopsy.

  14. Spontaneous ARIA (amyloid-related imaging abnormalities) and cerebral amyloid angiopathy related inflammation in presenilin 1-associated familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 Treatments

    Amyloid-related imaging abnormalities (ARIA), thought to reflect immune responses to vascular amyloid, have been detected in several amyloid-modifying therapy trials for Alzheimer's disease (AD).

  15. Increased CSF α-synuclein levels in Alzheimer's disease: correlation with tau levels

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-01-15 Tau biomarkers

    CSF α-synuclein levels were higher in AD patients as compared with cognitively healthy controls (P=.019) and patients with synucleinopathies (P<.001).

  16. Florbetapir (18F) for brain amyloid positron emission tomography: highlights on the European marketing approval

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-01-10 Brain scans and imaging

    Florbetapir (18F) for brain amyloid positron emission tomography (PET) imaging has been recently approved in Europe to estimate β-amyloid neuritic plaque density in the brain when the subject is still alive.

  17. Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009-07-17 Brain scans and imaging

    (18)F-flutemetamol uptake can be readily quantified.

  18. Hereditary dementia with intracerebral hemorrhages and cerebral amyloid angiopathy

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurology 2004-07-27 Risk genes beyond APOE

    Neuropathologic examination revealed Alzheimer-type changes with Abeta in neuritic plaques and vessel walls, but the cognitive profile of the patients differed from that in AD, as the visuoconstructive functions and verbal fluency were well preserved even in the moderate stage of the disease.

  19. Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular psychiatry 2003-03 Tau biomarkers

    Early clinical symptoms of sporadic Creutzfeldt-Jakob disease (CJD) may overlap with other neurodegenerative diseases like Alzheimer's disease (AD) and frontotemporal degeneration (FTD).

  20. Down syndrome and Alzheimer's disease: a link between development and aging

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Mental retardation and developmental disabilities research reviews 2001-01-01 Down syndrome and Alzheimer's

    A subset of aged individuals with Down syndrome (DS) exhibits the clinical features of Alzheimer's disease (AD) but our ability to detect dementia in this population is hampered by developmental differences as well as the sensitivity of existing test tools.

  21. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1992-09-01 Tau biomarkers

    Cerebral deposition of the beta-amyloid peptide (A beta) is an invariant feature of Alzheimer's disease.

  22. Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1990-06-01 Down syndrome and Alzheimer's

    Human hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), an autosomal dominant form of cerebral amyloid angiopathy (CAA), is characterized by extensive amyloid deposition in the small leptomeningeal arteries and cortical arterioles, which lead to an early death of those afflicted in their fifth or sixth decade.

  23. Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1989-09-01 Down syndrome and Alzheimer's

    Alzheimer's disease is the most common cause of progressive intellectual failure in aged humans.

  24. Optic-nerve degeneration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The New England journal of medicine 1986-08-01 Brain scans and imaging

    Alzheimer's disease is a dementing disorder of unknown cause in which there is degeneration of neuronal subpopulations in the central nervous system.

  25. MRI in the new era of antiamyloid mAbs for the treatment of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Current opinion in neurology 2023-06-23 Treatments

    Currently, three antibeta amyloid (Aβ) mAbs are approved or under examination in USA and in Europe for the treatment of patients with early Alzheimer's disease.

From across this topic

10 of the 1,573 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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