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Home › Research › Topics › mice

mice

1,163 studies tagged mice, dated 1986-01-01 to 2026-09-25. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia? 2026-09-25
  2. Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration 2026-09-20
  3. Laromestrocel preserves brain volume and cognitive function in Alzheimers disease by inhibiting neuroinflammation 2026-09-17

Studies

1,163 studies carry this tag.

Date range

1986 to 2026

Top journals

  • The Journal of biological chemistry 109
  • The Journal of neuroscience : the official journal of the Society for Neuroscience 42
  • Proceedings of the National Academy of Sciences of the United States of America 39
  • Neuron 28
  • Nature 23

365 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Environmental research 2015-06-01 Genetics

    Millions of Mexico, US and across the world children are overweight and obese.

  2. Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Science (New York, N.Y.) 2015-05-14 Lewy body dementia

    The major genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis is a G4C2 repeat expansion in C9ORF72.

  3. Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Annals of neurology 2015-05-11 Inflammation and the immune system

    Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, leading to memory impairment in up to 65% of patients.

  4. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of biological chemistry 2015-04-27 Down syndrome and Alzheimer's

    Hyperphosphorylation and dysregulation of exon 10 splicing of Tau are pivotally involved in pathogenesis of Alzheimer disease (AD) and/or other tauopathies.

  5. Can Studies of Neuroinflammation in a TSPO Genetic Subgroup (HAB or MAB) Be Applied to the Entire AD Cohort?

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2015-04-03 Biomarkers

    This study suggests that information obtained from evaluating a subgroup of AD or MCI subject using second-generation TSPO tracers can be translated to the entire AD and MCI population.

  6. TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2015-04-01 Brain tissue and pathology

    Therapeutic options for patients with amyotrophic lateral sclerosis (ALS) are currently limited.

  7. Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Annals of neurology 2015-03-21 Risk genes beyond APOE

    Currently no effective disease-modifying agents exist for the treatment of Alzheimer disease (AD).

  8. Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Cell death and differentiation 2015-03-06 Inflammation and the immune system

    Neuronal active Caspase-6 (Casp6) is associated with Alzheimer disease (AD), cognitive impairment, and axonal degeneration.

  9. Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular neurodegeneration 2015-03-05 Inflammation and the immune system

    Overexpression of apoE isoforms induces differential effects in the apoE4-TR background: apoE4 decreases apoE lipidation and enhances Aβ accumulation, whereas apoE2 has the opposite effects.

  10. Inhibition of c-Jun N-terminal kinase activation reverses Alzheimer disease phenotypes in APPswe/PS1dE9 mice

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Annals of neurology 2015-03-02 Risk genes beyond APOE

    Growing evidence indicates that the activation of c-Jun N-terminal kinase (JNK) is implicated in the multiple major pathological features of Alzheimer disease (AD).

  11. Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2015-02-01 Drug development

    Impaired insulin signaling pathway in the brain in type 2 diabetes (T2D) is a risk factor for Alzheimer disease (AD).

  12. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015-02-01 Risk genes beyond APOE

    Aging is the principal demographic risk factor for Alzheimer disease (AD), the most common neurodegenerative disorder.

  13. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature Communications 2015-01-29 Inflammation and the immune system

    In Alzheimer’s disease (AD), β-amyloid (Aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown.

  14. A novel DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of neurochemistry 2015-01-26 Down syndrome and Alzheimer's

    The dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) gene is located within the Down Syndrome (DS) critical region on chromosome 21 and is implicated in the generation of Tau and amyloid pathologies that are associated with the early onset Alzheimer's Disease (AD) observed in DS.

  15. RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2015-01-14 Disease mechanisms

    In the healthy adult brain synapses are continuously remodelled through a process of elimination and formation known as structural plasticity.

  16. An acetylation switch controls TDP-43 function and aggregation propensity

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature communications 2015-01-05 Lewy body dementia

    TDP-43 pathology is a disease hallmark that characterizes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP).

  17. Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 Disease mechanisms

    Abnormal hyperphosphorylation of microtubule-associated protein tau is involved in the pathogenesis of several neurodegenerative disorders including Alzheimer's disease (AD).

  18. Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 TREM2 and immune genetics

    Neuroinflammation occurs in Alzheimer's disease (AD).

  19. Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. PloS one 2014-12-04 Down syndrome and Alzheimer's

    Genetic alterations or pharmacological treatments affecting endocannabinoid signaling have profound effects on synaptic and neuronal properties and, under certain conditions, may improve higher brain functions.

  20. Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Experimental neurology 2014-12-04 Disease mechanisms

    Alzheimer's disease is the most prevalent tauopathy and cause of dementia.

  21. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Neuron 2014-12-01 Lewy body dementia

    Expanded GGGGCC (G4C2) nucleotide repeats within the C9ORF72 gene are the most common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  22. Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014-11-10 Risk genes beyond APOE

    Alterations in the Wnt signaling pathway have been implicated in Alzheimer's disease; however, its role in the processing of the amyloid precursor protein remains unknown.

  23. Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Molecular neurodegeneration 2014-10-26 Risk genes beyond APOE

    Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmarks of Alzheimer's disease (AD).

  24. Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropharmacology 2014-09-28 Disease mechanisms

    The receptor for advanced glycation end products (RAGE)-mediated signaling pathway is related to Aβ-induced pathogenic responses.

  25. Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2014-09-22 Disease mechanisms

    Mutations in the gene encoding ubiquilin2 (UBQLN2) cause amyotrophic lateral sclerosis (ALS), frontotemporal type of dementia, or both.

  26. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2014-09-18 Disease mechanisms

    Alzheimer's disease (AD) is an age-related neurological disorder characterized by synaptic loss and dementia.

  27. Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Neurobiology of disease 2014-08-15 Inflammation and the immune system

    Neuroinflammatory changes play a pivotal role in the progression of Parkinson's disease (PD) pathogenesis.

  28. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature protocols 2014-08-14 Lewy body dementia

    This protocol describes a primary neuronal model of formation of α-synuclein (α-syn) aggregates that recapitulate features of the Lewy bodies and Lewy neurites found in Parkinson's disease brains and other synucleinopathies.

  29. MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Molecular medicine reports 2014-08-12 Genetics

    Amyloid precursor protein (APP) has an important function in the generation of Alzheimer's disease (AD).

  30. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Science (New York, N.Y.) 2014-08-07 Lewy body dementia

    An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis.

  31. The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Anesthesia and analgesia 2014-08-01 Tau biomarkers

    Previous studies have shown that exposure to inhaled anesthetics can cause cognitive dysfunction, suggesting that general anesthesia might be a risk factor for the development of Alzheimer disease.

  32. Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Autophagy 2014-07-22 Inflammation and the immune system

    Accumulation of β-amyloid (Aβ) and resultant inflammation are critical pathological features of Alzheimer disease (AD).

  33. Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Biological psychiatry 2014-07-18 How common it is

    These data reinforce the link between gut dysbiosis and neurologic dysfunction and suggest that dietary and/or pharmacologic manipulation of gut microbiota could attenuate the neurologic complications of obesity.

  34. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature chemical biology 2014-06-29 Lewy body dementia

    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have distinct clinical features but a common pathology--cytoplasmic inclusions rich in transactive response element DNA-binding protein of 43 kDa (TDP43).

  35. A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Brain : a journal of neurology 2014-06-16 How common it is

    Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are extremely rare.

  36. Acupuncture stimulation of Taichong (Liv3) and Hegu (LI4) modulates the default mode network activity in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. American journal of Alzheimer's disease and other dementias 2014-06-06 Brain scans and imaging

    It was found that the acupuncture stimulation could modulate the DMN activity in AD.

  37. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Nature communications 2014-06-03 Brain tissue and pathology

    Mitochondria and the endoplasmic reticulum (ER) form tight structural associations and these facilitate a number of cellular functions.

  38. Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The American journal of pathology 2014-05-09 Risk genes beyond APOE

    Disrupted cholesterol homeostasis has been reported in Alzheimer disease and is thought to contribute to disease progression by promoting amyloid β (Aβ) accumulation.

  39. Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuroinflammation 2014-05-06 Prevention and risk

    Our results suggest that IF induces adaptive responses in the brain and periphery that can suppress inflammation and preserve cognitive function in an animal model of systemic bacterial infection.

  40. Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Stem cell research & therapy 2014-04-16 Brain scans and imaging

    Our data suggest that genetically-modified NSCs could provide a powerful combinatorial approach to not only enhance synaptic plasticity but to also target and modify underlying Alzheimer's disease pathology.

  41. Luteolin protects against high fat diet-induced cognitive deficits in obesity mice

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Behavioural brain research 2014-03-22 Inflammation and the immune system

    The epidemic and experimental studies have confirmed that the obesity can lead to neuroinflammation, neurodegenerative diseases and adversely affect cognition.

  42. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2014-03-21 Disease mechanisms

    The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity and synapse loss.

  43. Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. PLoS genetics 2014-03-20 Long-term cohort studies

    Circulating homocysteine levels (tHcy), a product of the folate one carbon metabolism pathway (FOCM) through the demethylation of methionine, are heritable and are associated with an increased risk of common diseases such as stroke, cardiovascular disease (CVD), cancer and dementia.

  44. C9orf72 nucleotide repeat structures initiate molecular cascades of disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature 2014-03-05 Lewy body dementia

    A hexanucleotide repeat expansion (HRE), (GGGGCC)n, in C9orf72 is the most common genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  45. Histone deacetylase 6 inhibition improves memory and reduces total tau levels in a mouse model of tau deposition

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's research & therapy 2014-02-27 Hippocampus size on brain scans

    Potential mechanisms by which HDAC6 inhibitors might benefit the rTg4510 mouse include stabilization of microtubules secondary to increased tubulin acetylation, increased degradation of tau secondary to increased acetylation of HSP90 or both.

  46. C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Human molecular genetics 2014-02-18 Lewy body dementia

    Intronic expansion of a hexanucleotide GGGGCC repeat in the chromosome 9 open reading frame 72 (C9ORF72) gene is the major cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

  47. Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain pathology (Zurich, Switzerland) 2014-02-12 Drug development

    Intracerebral-ventricular (ICV) injection of streptozotocin (STZ) induces an insulin-resistant brain state that may underlie the neural pathogenesis of sporadic Alzheimer disease (AD).

  48. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neuron 2014-02-01 Lewy body dementia

    The RNA-binding protein TDP-43 regulates RNA metabolism at multiple levels, including transcription, RNA splicing, and mRNA stability.

  49. c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cell death & disease 2014-01-23 Disease mechanisms

    Altered synaptic function is considered one of the first features of Alzheimer disease (AD).

  50. Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Journal of cell science 2014-01-14 Brain tissue and pathology

    TAR DNA-binding protein (TDP-43, also known as TARDBP) is the major pathological protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

From across this tag

10 of the 1,159 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts