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Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases
Brown DR, Kozlowski H.. Dalton transactions (Cambridge, England : 2003), 2004-05-11
Topic: Amyloid, tau and blood-test diagnosis
A change of the prion protein conformation results in a class of neurodegenerative diseases called the transmissible spongiform encephalopathies (like mad cow and Creutzfeld-Jakob diseases). The function of the normal prion protein is unknown, although much of recent research demonstrates the it may be a copper binding protein selective for Cu(II). Amyloid precursor protein (APP) releases the 39-42 amino acid peptide, a major constituent of the deposit in plaques of Alzheimer disease brain.
Key findings
- The function of the normal prion protein is unknown, although much of recent research demonstrates the it may be a copper binding protein selective for Cu(II).
- Amyloid precursor protein (APP) releases the 39-42 amino acid peptide, a major constituent of the deposit in plaques of Alzheimer disease brain.
- Also APP is a metal binding protein, including copper ions.
- The link between copper and both proteins may provide insight into the role of metals in neurodegenerative pathologies.
Why it matters
This review discusses the bioinorganic chemistry of copper and metal binding by the prion protein and amyloid precursor protein in neurodegeneration. It is a chemistry review and does not test any treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Dalton transactions (Cambridge, England : 2003)) |
| Journal's citation record | 2 / 4 | Dalton Transactions: journal h-index 228 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 343 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.3 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 3 / 6 | Cited 4.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 10 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Henryk Kozłowski: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | University of Bath: institution h-index 651 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15252577) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 41 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Brown, D. R., & Kozlowski, H. (2004). Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases. Dalton transactions (Cambridge, England : 2003). https://doi.org/10.1039/b401985g
Vancouver
Brown DR, Kozlowski H. Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases. Dalton transactions (Cambridge, England : 2003). 2004. doi:10.1039/b401985g. PMID: 15252577.
BibTeX
@article{brown2004-15252577,
author = {Brown, D. R. and Kozlowski, H.},
title = {{Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases}},
journal = {Dalton transactions (Cambridge, England : 2003)},
year = {2004},
doi = {10.1039/b401985g},
pmid = {15252577},
url = {https://doi.org/10.1039/b401985g}
}
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