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Home › Research › Topics › apoe

apoe

1,350 studies tagged apoe, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,350 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in neuroscience 2020-08-28 Genetics

    Obesity is a multifactorial disease in which environmental conditions and several genes play an important role in the development of this disease.

  2. Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. PLoS medicine 2020-08-20 Tau biomarkers

    The ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most important known risk factors for developing Alzheimer disease (AD).

  3. Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Frontiers in aging neuroscience 2020-08-20 Risk genes beyond APOE

    In 1907, Alois Alzheimer observed, as he quoted, development of "numerous fibers" and "adipose saccules" in the brain of his diseased patient Auguste Deter.

  4. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. EMBO molecular medicine 2020-08-10 TREM2 and immune genetics

    Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's disease (AD).

  5. Serum albumin and beta-amyloid deposition in the human brain

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2020-07-20 Brain scans and imaging

    Low serum albumin may increase the risk of AD dementia by elevating amyloid accumulation.

  6. β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Communications biology 2020-07-06 Digital health tools

    Clinical trials focusing on therapeutic candidates that modify β-amyloid (Aβ) have repeatedly failed to treat Alzheimer's disease (AD), suggesting that Aβ may not be the optimal target for treating AD.

  7. Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. JAMA neurology 2020-07-01 Genetics

    The genotype KL-VSHET+ is associated with reduced AD risk and Aβ burden in individuals who are aged 60 to 80 years, cognitively normal, and carrying APOE4.

  8. Cellular senescence and Alzheimer disease: the egg and the chicken scenario

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Nature reviews. Neuroscience 2020-06-29 Inflammation and the immune system

    Globally, 50 million people live with dementia, with Alzheimer disease (AD) being responsible for two-thirds of the total cases.

  9. Effect of ApoE isoforms on mitochondria in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2020-05-26 Genetics

    ApoE isoforms influence mitochondrial structure and function, which likely leads to alteration in oxidative stress, synapses, and cognitive function.

  10. A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Scientific reports 2020-05-20 Disease mechanisms

    Since the world population is ageing, dementia is going to be a growing concern.

  11. Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging cell 2020-05-17 Disease mechanisms

    The pathogenesis of Alzheimer's disease (AD) and the commonest cause of dementia in the elderly remain incompletely understood.

  12. Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2020-04-14 Brain scans and imaging

    Our proof-of-concept study is the first to show that microstructural and macrostructural changes can reflect underlying neuroinflammatory mechanisms in early stages of Alzheimer disease (AD).

  13. A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neurochemistry 2020-04-05 Disease mechanisms

    It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in considerable part from synaptic dysfunction caused by the accumulation of a range of oligomeric assemblies of amyloid β-protein (Aβ).

  14. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. The Journal of clinical investigation 2020-04-01 Inflammation and the immune system

    Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy.

  15. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neuron 2020-03-20 TREM2 and immune genetics

    Evidence suggests interplay among the three major risk factors for Alzheimer's disease (AD): age, APOE genotype, and sex.

  16. The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurochemical research 2020-03-13 Risk genes beyond APOE

    Peroxisome proliferator activated receptor alpha (PPAR-α) belongs to the family of ligand-regulated nuclear receptors (PPARs).

  17. Association of Intracranial Atherosclerotic Disease With Brain β-Amyloid Deposition: Secondary Analysis of the ARIC Study

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA neurology 2020-03-01 Long-term cohort studies

    Intracranial atherosclerotic disease (ICAD) is an important cause of stroke and has also been recently identified as an important risk factor for all-cause dementia, but the mechanism of its association with cognitive performance is not fully understood.

  18. Associations between brain inflammatory profiles and human neuropathology are altered based on apolipoprotein E ε4 genotype

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Scientific reports 2020-02-19 Genetics

    Alzheimer disease (AD) is a chronic neurodegenerative disease with a multitude of contributing genetic factors, many of which are related to inflammation.

  19. Impact of HMGB1, RAGE, and TLR4 in Alzheimer's Disease (AD): From Risk Factors to Therapeutic Targeting

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Cells 2020-02-07 Inflammation and the immune system

    Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a leading cause of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as defining pathological features.

  20. Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neurobiology of disease 2020-02-06 Genetics

    Inheritance of apolipoprotein E4 (APOE4) is a major risk factor for development of Alzheimer's disease (AD).

  21. Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. Brain communications 2020-02-06 Mild cognitive impairment

    Regions with early signs of elevated amyloid β uptake were used to form an early, focal composite and compared to a commonly used global composite, in a separate validation sample.

  22. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Nature communications 2020-02-03 Prevention and risk

    Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk.

  23. APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Science translational medicine 2020-02-01 Disease mechanisms

    The apolipoprotein E ( APOE ) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease mainly by driving amyloid-β pathology.

  24. APOE genotype regulates pathology and disease progression in synucleinopathy

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Science translational medicine 2020-02-01 Caregiving

    Apolipoprotein E ( APOE ) ε4 genotype is associated with increased risk of dementia in Parkinson's disease (PD), but the mechanism is not clear, because patients often have a mixture of α-synuclein (αSyn), amyloid-β (Aβ), and tau pathologies.

  25. Glycogen synthase kinase-3 signaling in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Biochimica et biophysica acta. Molecular cell research 2020-01-30 Caregiving

    Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with dementia, accounting for approximately 70% of the all cases.

  26. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. EMBO molecular medicine 2020-01-17 Genetics

    Polygenic risk scores have identified that genetic variants without genome-wide significance still add to the genetic risk of developing Alzheimer's disease (AD).

  27. Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Brain : a journal of neurology 2020-01-01 Risk genes beyond APOE

    Temporal lobe epilepsy represents a major cause of drug-resistant epilepsy.

  28. Telomere Length and the Risk of Alzheimer's Disease: The Rotterdam Study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of Alzheimer's disease : JAD 2020-01-01 Long-term cohort studies

    There is a wide interest in biomarkers that capture the burden of detrimental factors as these accumulate with the passage of time, i.e., increasing age.

  29. The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Neurosciences (Riyadh, Saudi Arabia) 2020-01-01 Inflammation and the immune system

    Chain-free SFA and TFA occur in greater amounts in the brains of individuals with AD than in those without AD.

  30. HHV-6A infection induces amyloid-beta expression and activation of microglial cells

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Alzheimer's research & therapy 2019-12-12 TREM2 and immune genetics

    The control of viral infections in the brain involves the activation of microglial cells, the macrophages of the brain that are constantly surveying the central nervous system, and the production of amyloid-beta (Aβ) as an anti-microbial molecule.

  31. Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Nature reviews. Neurology 2019-12-11 Brain tissue and pathology

    The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and Alzheimer disease (AD) is arguably the clearest instance of crosstalk between neurodegenerative and cerebrovascular processes.

  32. Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Neuron 2019-11-20 Caregiving

    Studies have shown an overlap of Aβ plaques, tau tangles, and α-synuclein (α-syn) pathologies in the brains of Alzheimer's disease (AD) and Parkinson's disease (PD) with dementia (PDD) patients, with increased pathological burden correlating with severity of cognitive and motor symptoms.

  33. Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Molecular neurodegeneration 2019-10-17 Genetics

    These new knock-in strains offer a novel and dynamic tool to study the role of APOE in AD pathogenesis in a spatially and temporally controlled manner.

  34. Causal Effect of Lp(a) [Lipoprotein(a)] Level on Ischemic Stroke and Alzheimer Disease: A Mendelian Randomization Study

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Stroke 2019-10-10 Genetics

    This study provides evidence to support that high Lp(a) concentrations was causally associated with an increased risk of large artery stroke but a decreased risk of small vessel stroke and Alzheimer disease.

  35. Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Brain communications 2019-10-10 TREM2 and immune genetics

    Genome-wide association studies of late-onset Alzheimer's disease risk have previously identified genes primarily expressed in microglia that form a transcriptional network.

  36. An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Nature neuroscience 2019-10-07 Getting a diagnosis

    Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; n control = 13; n AD = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC).

  37. APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Neurology 2019-10-01 Brain scans and imaging

    APOE ε4 may influence the association between WMH and cognitive performance in AD and DLB.

  38. GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. American journal of human genetics 2019-09-26 Prevention and risk

    Age-related hearing impairment (ARHI) is the most common sensory impairment in the aging population; a third of individuals are affected by disabling hearing loss by the age of 65.

  39. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Stem cell reports 2019-09-12 Inflammation and the immune system

    Here we elucidate the effect of Alzheimer disease (AD)-predisposing genetic backgrounds, APOE4, PSEN1ΔE9, and APPswe, on functionality of human microglia-like cells (iMGLs).

  40. Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2019-08-28 Caregiving

    The regulation of vasculature is a prominent causal component of probable AD.

  41. Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion protein

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Acta neuropathologica 2019-08-14 Risk genes beyond APOE

    Extracellular deposition of amyloid β-protein (Aβ) in amyloid plaques and intracellular accumulation of abnormally phosphorylated τ-protein (p-τ) in neurofibrillary tangles (NFTs) represent pathological hallmark lesions of Alzheimer's disease (AD).

  42. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Nature reviews. Neurology 2019-07-31 Genetics

    Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of late-onset Alzheimer disease (AD), with the APOE*ε4 allele conferring an increased risk and the APOE*ε2 allele conferring a decreased risk relative to the common APOE*ε3 allele.

  43. Association of Early-Onset Alzheimer Disease With Elevated Low-Density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. JAMA neurology 2019-07-01 Genetics

    Elevated LDL-C levels were associated with higher probability of having EOAD, and EOAD cases were enriched for rare coding variants in APOB, which codes for the major protein of LDL-C.

  44. F4‐01‐05: RACIAL AND ETHNIC DIFFERENCES IN AMYLOID PET POSITIVITY IN THE IDEAS STUDY

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Alzheimer s & Dementia 2019-07-01 Health systems and care delivery

    Racial and ethnic differences in Alzheimer's disease (AD) and related dementias are well documented.

  45. Melatonin in Alzheimer's Disease: A Latent Endogenous Regulator of Neurogenesis to Mitigate Alzheimer's Neuropathology

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Molecular neurobiology 2019-06-17 Disease mechanisms

    Melatonin, a pineal gland synthesized neurohormone is known as a multifunctioning pleiotropic agent which has a wide range of neuroprotective role in manifold age-related neurodegenerative disorders especially Alzheimer's diseases (AD).

  46. Mediterranean and MIND Diets Containing Olive Biophenols Reduces the Prevalence of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2019-06-07 Prevention trials

    The risk of Alzheimer's disease (AD) increases with nonmodifiable conditions including age and lack of effective efficacious pharmacotherapy.

  47. Endo-lysosomal dysregulations and late-onset Alzheimer's disease: impact of genetic risk factors

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Molecular neurodegeneration 2019-06-03 TREM2 and immune genetics

    Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer's disease.

  48. APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Acta neuropathologica communications 2019-05-21 TREM2 and immune genetics

    Microglia affect Alzheimer's disease (AD) pathogenesis in opposing manners, by protecting against amyloid accumulation in early phases of the disease and promoting neuropathology in advanced stages.

  49. Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. British journal of pharmacology 2019-05-11 TREM2 and immune genetics

    One of the largest unmet medical needs is a disease-modifying treatment for Alzheimer's disease (AD).

  50. Alzheimer's Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. mBio 2019-05-07 How common it is

    Alzheimer's disease (AD), the most common cause of dementia, has long been associated with bacterial infections and inflammation-causing immunosenescence.

From across this tag

10 of the 1,348 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts