alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topics › apoe

apoe

1,346 studies tagged apoe, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,346 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-08-01 Risk genes beyond APOE

    The A4 or beta protein is a peptide that constitutes the major protein component of senile plaques in Alzheimer disease.

  2. Beta-amyloid precursor protein cleavage by a membrane-bound protease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-07-01 Risk genes beyond APOE

    The principal component of amyloid plaques in Alzheimer disease is beta-amyloid protein, an approximately 4-kDa peptide derived from amyloid precursor proteins.

  3. Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Nature genetics 1992-06-01 Brain tissue and pathology

    Several families with an early-onset form of familial Alzheimer's disease have been found to harbour mutations at a specific codon (717) of the gene for the beta-amyloid precursor protein (APP) on chromosome 21.

  4. Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1992-04-01 Risk genes beyond APOE

    Extracellular deposition of the beta/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer disease. beta/A4 amyloid is derived from the amyloid precursor protein (APP), an integral membrane protein that exists as three major isoforms (APP695, APP751, and APP770).

  5. The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Alzheimer disease and associated disorders 1992-01-01 Risk genes beyond APOE

    New molecular information about Alzheimer disease (AD) is appearing at an unprecedented rate.

  6. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1991-12-01 Risk genes beyond APOE

    beta-Amyloid formation requires multiple abnormal proteolytic cleavages of amyloid precursor protein (APP), including one within its intramembrane domain.

  7. Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Brain research 1991-11-01 Risk genes beyond APOE

    We have recently shown that the amyloid beta A4 precursor protein (APP) is synthesized in neurons and undergoes fast axonal transport to synaptic sites [Koo et al., Proc.

  8. The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1991-11-01 Down syndrome and Alzheimer's

    The amyloid beta protein and the amyloid beta-protein precursor (APP) are major constituents of senile plaques and cerebrovascular deposits in patients with Alzheimer disease and Down syndrome.

  9. Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Annals of Neurology 1991-10-01 Brain tissue and pathology

    We present here both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural and neurochemical measurements performed on a prospective series of 15 patients with Alzheimer's disease and 9 neuropathologically normal subjects.

  10. APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. American journal of human genetics 1991-09-01 Down syndrome and Alzheimer's

    The amyloid precursor protein (APP) gene codes for the precursor to the beta-protein found in the amyloid deposits of Alzheimer disease (AD).

  11. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1991-09-01 Risk genes beyond APOE

    Senile plaques are polymorphous beta-amyloid protein deposits found in the brain in Alzheimer disease and normal aging.

  12. Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. American journal of human genetics 1991-06-01 Brain tissue and pathology

    A genetic component in the etiology of Alzheimer disease (AD) has been supported by indirect evidence for several years, with autosomal dominant inheritance with age-dependent penetrance being suggested to explain the familial aggregation of affecteds.

  13. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Nature 1991-02-21 Genetics

    To avoid the problems that heterogeneity poses for genetic analysis, the researchers examined the cosegregation of Alzheimer's disease and markers along the long arm of chromosome 21 in a single family.

  14. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain Research 1991-02-01 Brain tissue and pathology

    Researchers conducted immunohistochemical studies on lipid changes in Alzheimer's disease brains using an antibody to apolipoprotein E. They unexpectedly discovered that apo E immunoreactivity was associated with amyloid in senile plaques, cerebral vessels, and neurofibrillary tangles, as well as in kuru plaques in Creutzfeldt-Jakob disease.

  15. The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Brain research. Molecular brain research 1991-02-01 Down syndrome and Alzheimer's

    Transcriptional regulation of the gene encoding the amyloid precursor protein (APP) may play an important role in the formation of the amyloid depositions observed in Alzheimer disease and Down syndrome patients.

  16. Measurement of amyloid peptide precursor of Alzheimer disease in human blood by double antibody immunoradiometric assay

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alzheimer disease and associated disorders 1991-01-01 Down syndrome and Alzheimer's

    The dementia of Alzheimer disease (AD) correlates with the deposition of extracellular amyloid, and this amyloid arises from the abnormal processing of a high molecular weight amyloid peptide precursor (APP), which is a normal cellular protein that is found in both brain and in peripheral tissues in humans.

  17. Glial fibrillary acidic protein and beta A4 protein deposits in temporal lobe of aging brain and senile dementia of the Alzheimer type: relation with the cognitive state and with quantitative studies of senile plaques and neurofibrillary tangles

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroscience research 1990-12-01 Biomarkers

    The aim of this study was to compare brain glial fibrillary acidic protein (GFAP) levels to the modifications of cognitive functions (Blessed test score [BTS]), the density of the main neuropathological lesions (senile plaques [SP] and neurofibrillary tangles [NFT]), and the density of the two main subtypes of beta A4 deposits (classic plaques and diffuse deposits) in a series of patients with normal aging and senile dementia of the Alzheimer type of various degrees of severity.

  18. Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neuroscience letters 1990-10-01 Inflammation and the immune system

    Alzheimer senile plaques are comprised of extracellular deposits of beta-amyloid.

  19. The amyloid precursor protein of Alzheimer's disease is released by human platelets

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of biological chemistry 1990-09-01 Risk genes beyond APOE

    Western blots of normal human platelets, employing a monoclonal antibody raised against the full-length amyloid precursor protein of Alzheimer's disease (APP695), revealed major bands of 100-110 and 120-130 kDa in both cytosolic, membrane, and released fractions.

  20. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1990-08-01 Risk genes beyond APOE

    The turnover and processing of the Alzheimer beta/A4 amyloid precursor protein (beta APP) has been studied in PC12 cells after treatment with agents that regulate protein phosphorylation.

  21. Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 1990-07-01 Inflammation and the immune system

    Expression of major histocompatibility complex (MHC) class I (HLA-A,B,C) and class II (HLA-DR) antigens was studied in postmortem brain tissue of Alzheimer's disease and age-matched control cases.

  22. Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Science 1990-06-01 Risk genes beyond APOE

    An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with Alzheimer's disease, Down syndrome, and sporadic cerebral amyloid angiopathy.

  23. Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Science (New York, N.Y.) 1990-06-01 Risk genes beyond APOE

    An inhibitor of coagulation factor XIa was purified from serum-free conditioned medium of HepG2 liver cells.

  24. Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1990-05-01 Risk genes beyond APOE

    The formation of beta-amyloid in the brains of individuals with Alzheimer disease requires the proteolytic cleavage of a membrane-associated precursor protein.

  25. Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain research 1990-04-01 Risk genes beyond APOE

    To investigate the role of proteolysis in amyloid formation, we studied the localization of the proteolytic enzymes, cathepsin D and cathepsin B, in the prefrontal cerebral cortex and hippocampus of human postmortem brains from patients with Alzheimer's disease and from individuals free of neurological disease.

  26. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Journal of Lipid Research 1990-03-01 Genetics

    We have used restriction isotyping (restriction enzyme isoform genotyping) for rapid typing of common apolipoprotein E isoforms (E2, E3, E4).

  27. The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The Journal of biological chemistry 1990-03-01 Risk genes beyond APOE

    The amyloid forming beta-peptide of Alzheimer's disease is synthesized as part of a larger integral membrane precursor protein (beta APP) of which three alternatively spliced versions of 695, 751, and 770 amino acids have been described.

  28. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1990-02-01 Risk genes beyond APOE

    In the brains of aged humans and cases of Alzheimer disease, deposits of amyloid in senile plaques are located in proximity to nerve processes.

  29. Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Acta neuropathologica 1990-01-01 Inflammation and the immune system

    A strong immunoreactivity for ferritin was observed in the neuritic (senile) plaques in Alzheimer's disease hippocampus.

  30. The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Experimental neurology 1989-12-01 Risk genes beyond APOE

    The 4.2-kilodalton (kDa) polypeptide associated with the cerebral amyloid deposits of Alzheimer's disease (AD) derives from a much larger protein that is encoded by a gene on chromosome 21.

  31. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of neuroimmunology 1989-10-01 Inflammation and the immune system

    The relationship of microglia and astrocytes to deposits of beta-amyloid protein (BAP) was studied in Alzheimer's disease by immunohistochemistry.

  32. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 1989-08-01 Disease mechanisms

    Alzheimer disease (AD) as well as other dementing disorders are characterized by a continuous loss of neurons in cortical and subcortical areas and probably by an extensive synaptic loss.

  33. Altered expression of genes for amyloid and cytoskeletal proteins in Alzheimer cortex

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Annals of neurology 1989-04-01 Biomarkers

    Recent studies have indicated a normal gene dose for the amyloid precursor protein (APP) in Alzheimer's disease (AD).

  34. The immunohistochemical demonstration of subsequences of the precursor of the amyloid A4 protein in senile plaques in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropathology and applied neurobiology 1989-03-01 Biomarkers

    The actual presence of the predicted precursor of Alzheimer's disease amyloid A4 protein, reported by Kang et al. (1987) in the Alzheimer brain, has yet to be verified.

  35. Elevated levels of an exocrine pancreatic secretory protein in Alzheimer disease brain

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1989-01-01 Down syndrome and Alzheimer's

    We identified by a monoclonal antibody-based immunoradiometric assay high concentrations of an exocrine pancreatic protein called pancreatic thread protein (PTP) in several areas of Alzheimer disease (AD) brain.

  36. The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. FEBS letters 1988-12-01 Down syndrome and Alzheimer's

    The vascular and parenchymal amyloid deposits in Alzheimer disease (AD), normal aging and Down syndrome are mainly composed of a 4 kDa polypeptide (A4), which derives from a larger precursor protein (APP).

  37. Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1988-10-01 Risk genes beyond APOE

    Progressive cerebral deposition of extracellular filaments composed of the beta-amyloid protein (beta AP) is a constant feature of Alzheimer disease (AD).

  38. Glial fibrillary acidic protein immunohistochemical study of Alzheimer I & II astrogliosis in Wilson's disease

    ✓ Peer-reviewed alzhub usefulness score 30 out of 100. Acta neurologica Scandinavica 1988-10-01 Biomarkers

    This study compared the relationships of the development of both Alzheimer I & II cells to reactive astrogliosis and also their distributional patterns in the demyelinated and non-demyelinated lesions in 6 cases of Wilson's disease by the use of PAP immunohistochemical technique for glial fibrillary acidic protein (GFAP).

  39. Presence of T-cytotoxic suppressor and leucocyte common antigen positive cells in Alzheimer's disease brain tissue

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Neuroscience letters 1988-09-01 Inflammation and the immune system

    Cells expressing leucocyte common antigen (LCA) as well as T-cytotoxic-suppressor (T8) and T-helper-inducer (T4) antigens were detected in significant numbers in the hippocampus and temporal cortex of Alzheimer but not normal brain tissue.

  40. Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Science 1988-04-29 Genetics

    Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body.

  41. Preparation of a recombinant cDNA library from poly(A+) RNA of the Alzheimer brain. Identification and characterization of a cDNA copy encoding a glial-specific protein

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Neurobiology of aging 1988-03-01 Biomarkers

    Studies were undertaken to assess the extent to which messenger RNA prepared from the postmortem Alzheimer's disease (AD) brain can be used for the successful preparation of a recombinant cDNA library.

  42. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature 1988-02-01 Risk genes beyond APOE

  43. Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Science 1987-02-20 Risk genes beyond APOE

    Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the beta peptide of brain amyloid from Alzheimer's disease.

  44. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Science (New York, N.Y.) 1987-02-01 Down syndrome and Alzheimer's

    The amyloid beta protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome.

  45. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Nature 1987-02-01 Disease mechanisms

    The researchers isolated and sequenced an apparently full-length complementary DNA clone coding for the A4 polypeptide.

  46. Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Science (New York, N.Y.) 1982-09-01 Getting a diagnosis

    Scanning electron microscopy with energy-dispersive x-ray spectrometry was used to analyze the elemental content of neurofibrillary tangle (NFT)-bearing and NFT-free neurons within the Sommer's sector (H1 region) of the hippocampus in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia and in neurologically normal controls.

From across this tag

10 of the 1,344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts