Home › Research › Brain scans and imaging
The default mode network is disrupted in Parkinson's disease with visual hallucinations
Nailin Yao, Richard Shek-Kwan Chang, Charlton Cheung, Shirley Pang, Kui Kai Lau, John Suckling, James B Rowe, Kevin Yu et al.. Human brain mapping, 2014-07-01
Topic: Brain imaging, connectivity and assessment
There were no group differences in cortical thickness but functional coactivation within components of the DMN was significantly lower in both PDVH and PDnonVH groups compared to HC. Functional coactivation within the DMN was found to be greater in PDVH group relative to PDnonVH group. Our study demonstrates, for the first time that, within a functionally abnormal DMN in PD, relatively higher "connectivity" is associated with VH. We postulate that aberrant connectivity in a large scale network affects sensory information processing and perception, and contributes to "positive" symptom generation in PD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Yao, N., Chang, R. S.-K., Cheung, C., Pang, S., Lau, K. K., Suckling, J., et al. (2014). The default mode network is disrupted in Parkinson's disease with visual hallucinations. Human brain mapping. https://doi.org/10.1002/hbm.22577
Vancouver
Yao N, Chang RS.-K, Cheung C, Pang S, Lau KK, Suckling J, et al. The default mode network is disrupted in Parkinson's disease with visual hallucinations. Human brain mapping. 2014. doi:10.1002/hbm.22577. PMID: 24985056.
BibTeX
@article{yao2014-24985056,
author = {Yao, Nailin and Chang, Richard Shek-Kwan and Cheung, Charlton and Pang, Shirley and Lau, Kui Kai and Suckling, John and Rowe, James B and Yu, Kevin and others},
title = {{The default mode network is disrupted in Parkinson's disease with visual hallucinations}},
journal = {Human brain mapping},
year = {2014},
doi = {10.1002/hbm.22577},
pmid = {24985056},
url = {https://doi.org/10.1002/hbm.22577}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- There were no group differences in cortical thickness but functional coactivation within components of the DMN was significantly lower in both PDVH and PDnonVH groups compared to HC.
- Functional coactivation within the DMN was found to be greater in PDVH group relative to PDnonVH group.
- Our study demonstrates, for the first time that, within a functionally abnormal DMN in PD, relatively higher "connectivity" is associated with VH.
- We postulate that aberrant connectivity in a large scale network affects sensory information processing and perception, and contributes to "positive" symptom generation in PD.
New to this subject? Start with our plain-English guide: Brain scans & tests →
Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 21 of the 56 points we could judge it on, which is 38 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Human brain mapping) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2014 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 24985056) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 21 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 21 of the 56 points we could judge it on is 38 out of 100. |
| Total | 38 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related studies in Brain scans and imaging
Also tagged “connectivity”
187 studies in the library carry the topic tag “connectivity”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 187 tagged studies.