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Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study
Schoonhoven DN, Coomans EM, Millán AP, van Nifterick AM, Visser D, Ossenkoppele R, Tuncel H, van der Flier WM et al.. Brain : a journal of neurology, 2023-10-01
Topic: Brain proteins, microglia and lab models
Recent studies on Alzheimer's disease (AD) suggest that tau proteins spread through the brain following neuronal connections. To assess performance, model output was compared to the group-specific tau deposition patterns as measured with 18F-flortaucipir PET. These results suggest that in addition to structural connections, functional connections play an important role in tau spread, and highlight that neuronal dynamics play a key role in promoting this pathological process. Our results also suggest that this process is more important in earlier disease stages (preclinical AD/MCI); possibly, in later stages, other processes may be influential.
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APA 7th
Schoonhoven, D. N., Coomans, E. M., Millán, A. P., van Nifterick, A. M., Visser, D., Ossenkoppele, R., et al. (2023). Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study. Brain : a journal of neurology. https://doi.org/10.1093/brain/awad189
Vancouver
Schoonhoven DN, Coomans EM, Millán AP, van Nifterick AM, Visser D, Ossenkoppele R, et al. Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study. Brain : a journal of neurology. 2023. doi:10.1093/brain/awad189. PMID: 37279597.
BibTeX
@article{schoonhoven2023-37279597,
author = {Schoonhoven, D. N. and Coomans, E. M. and Millán, A. P. and van Nifterick, A. M. and Visser, D. and Ossenkoppele, R. and Tuncel, H. and van der Flier, W. M. and others},
title = {{Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study}},
journal = {Brain : a journal of neurology},
year = {2023},
doi = {10.1093/brain/awad189},
pmid = {37279597},
url = {https://doi.org/10.1093/brain/awad189}
}
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Key findings
- Recent studies on Alzheimer's disease (AD) suggest that tau proteins spread through the brain following neuronal connections.
- To assess performance, model output was compared to the group-specific tau deposition patterns as measured with 18F-flortaucipir PET.
- These results suggest that in addition to structural connections, functional connections play an important role in tau spread, and highlight that neuronal dynamics play a key role in promoting this pathological process.
- Our results also suggest that this process is more important in earlier disease stages (preclinical AD/MCI); possibly, in later stages, other processes may be influential.
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Study details
- Study designcross-sectional
- Participants16
- Evidence strengthLow
How this study scored 60/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 35 of the 58 points we could judge it on, which is 60 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 16 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37279597) |
| Free to read | 2 / 2 | Free to read |
| Points | 35 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 35 of the 58 points we could judge it on is 60 out of 100. |
| Total | 60 / 100 | — |
What each of these 20 components measures, and what this score is not →
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