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Slowing of oscillatory brain activity is a stable characteristic of Parkinson's disease without dementia
Stoffers D, Bosboom JL, Deijen JB, Wolters EC, Berendse HW, Stam CJ.. Brain : a journal of neurology, 2007-04-05
Topic: Brain proteins, microglia and lab models
Plain-language summary
Extensive changes in resting-state oscillatory brain activity have recently been demonstrated using magnetoencephalography (MEG) in moderately advanced, non-demented Parkinson's disease patients relative to age-matched controls. Neuropsychological assessment revealed abnormal perseveration in de novo patients, which was associated with increased low alpha power in centroparietal ROIs. In the whole group of Parkinson's disease patients, longer disease duration was associated with reduced low alpha power in the right temporal and right occipital ROI, but not with any other spectral power measure. In patients on levodopa therapy, a change from the 'OFF' to the 'ON' state was associated with decreases in right frontal theta, left occipital beta and left temporal gamma power and an increase in right parietal gamma power. Some early cognitive deficits in Parkinson's disease appear to be associated with increased low alpha power.
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APA 7th
Stoffers, D., Bosboom, J. L., Deijen, J. B., Wolters, E. C., Berendse, H. W., & Stam, C. J. (2007). Slowing of oscillatory brain activity is a stable characteristic of Parkinson's disease without dementia. Brain : a journal of neurology. https://doi.org/10.1093/brain/awm034
Vancouver
Stoffers D, Bosboom JL, Deijen JB, Wolters EC, Berendse HW, Stam CJ. Slowing of oscillatory brain activity is a stable characteristic of Parkinson's disease without dementia. Brain : a journal of neurology. 2007. doi:10.1093/brain/awm034. PMID: 17412733.
BibTeX
@article{stoffers2007-17412733,
author = {Stoffers, D. and Bosboom, J. L. and Deijen, J. B. and Wolters, E. C. and Berendse, H. W. and Stam, C. J.},
title = {{Slowing of oscillatory brain activity is a stable characteristic of Parkinson's disease without dementia}},
journal = {Brain : a journal of neurology},
year = {2007},
doi = {10.1093/brain/awm034},
pmid = {17412733},
url = {https://doi.org/10.1093/brain/awm034}
}
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Key findings
- Extensive changes in resting-state oscillatory brain activity have recently been demonstrated using magnetoencephalography (MEG) in moderately advanced, non-demented Parkinson's disease patients relative to age-matched controls.
- Neuropsychological assessment revealed abnormal perseveration in de novo patients, which was associated with increased low alpha power in centroparietal ROIs.
- In the whole group of Parkinson's disease patients, longer disease duration was associated with reduced low alpha power in the right temporal and right occipital ROI, but not with any other spectral power measure.
- In patients on levodopa therapy, a change from the 'OFF' to the 'ON' state was associated with decreases in right frontal theta, left occipital beta and left temporal gamma power and an increase in right parietal gamma power.
- Some early cognitive deficits in Parkinson's disease appear to be associated with increased low alpha power.
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Study details
- Participants37
- Evidence strengthLow
How this study scored 47/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 27 of the 58 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2007 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 37 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17412733) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 27 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 27 of the 58 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
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