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59/100

✓ Peer-reviewed alzhub usefulness score 59 out of 100. Cognitive tests and assessment

Topic: Risk, prevention and care in population studies

Objective To determine if scopolamine-induced cognitive impairment in healthy elderly people predicts cognitive decline 6 years later. Design Prospective cohort study. Setting Elderly care research unit. Participants Healthy elderly people who were part of a volunteer panel of research subjects. Interventions Scopolamine 0.2 mg administered subcutaneously at baseline. Main outcome measures Cognitive drug research computerized cognitive testing battery pre- and post-scopolamine, with repeat testing over 6 years later. Main results 16/24 subjects were retested. Although marked decrements in cognitive functioning were seen with scopolamine, there was little change in performance over 6 years, and no significant association was seen between scopolamine-induced decrement and change over time. Conclusions The scopolamine challenge test is not likely to play a role in the preclinical diagnosis of Alzheimer's disease.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Barker, A., Jones, R., Prior, J., & Wesnes, K. (1998). Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers: a 6-year follow-up. International journal of geriatric psychiatry. https://doi.org/10.1002/(sici)1099-1166(199804)13:4<244::aid-gps764>3.0.co;2-1

Vancouver

Barker A, Jones R, Prior J, Wesnes K. Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers: a 6-year follow-up. International journal of geriatric psychiatry. 1998. doi:10.1002/(sici)1099-1166(199804)13:4<244::aid-gps764>3.0.co;2-1. PMID: 9646152.

BibTeX

@article{barker1998-9646152,
  author  = {Barker, A. and Jones, R. and Prior, J. and Wesnes, K.},
  title   = {{Scopolamine-induced cognitive impairment as a predictor of cognitive decline in healthy elderly volunteers: a 6-year follow-up}},
  journal = {International journal of geriatric psychiatry},
  year    = {1998},
  doi     = {10.1002/(sici)1099-1166(199804)13:4<244::aid-gps764>3.0.co;2-1},
  pmid    = {9646152},
  url     = {https://doi.org/10.1002/(sici)1099-1166(199804)13:4<244::aid-gps764>3.0.co;2-1}
}

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Key findings

Main results 16/24 subjects were retested.
Although marked decrements in cognitive functioning were seen with scopolamine, there was little change in performance over 6 years, and no significant association was seen between scopolamine-induced decrement and change over time.

Study details

Study designcohort study
Participants24
Evidence strengthModerate

How this study scored 59/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 34 of the 58 points we could judge it on, which is 59 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (International journal of geriatric psychiatry)
Journal's citation record	— / 4	No journal record from OpenAlex — left out of this score
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	1998 — older than 20 years, still counted
Sample size	1 / 4	24 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	— / 7	No citation count (not found in OpenAlex) — left out of this score
Citations per year	— / 5	No citation count or no year — left out of this score
Impact for its field and year	— / 6	No field-weighted citation impact (OpenAlex has none yet) — left out of this score
Cited by studies here	— / 6	Not yet checked against this library's citation graph — left out of this score
Still being cited	— / 4	No yearly citation counts — left out of this score
Senior author's track record	— / 4	Senior author's record not available — left out of this score
Institution's track record	— / 3	No institution listed in OpenAlex — left out of this score
Multi-centre collaboration	— / 3	Institutions not listed — left out of this score
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 9646152)
Free to read	0 / 2	Behind a paywall — scores zero
Points	34 / 58	Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 34 of the 58 points we could judge it on is 59 out of 100.
Total	59 / 100	—

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