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42/100

✓ Peer-reviewed alzhub usefulness score 42 out of 100. Inflammation and the immune system

Topic: Brain proteins, microglia and lab models

Plain-language summary

In most neurodegenerative disorders, including multiple sclerosis, Parkinson disease, and Alzheimer disease, a massive neuronal cell death occurs as a consequence of an uncontrolled inflammatory response, where activated astrocytes and microglia and their cytotoxic agents play a crucial pathological role. Current treatments for these diseases are not effective. In the present study we investigate the effect of thiadiazolidinone derivatives, which have been recently suggested to play a role in neurodegenerative disorders.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Luna-Medina, R., Cortes-Canteli, M., Alonso, M., Santos, A., Martínez, A., & Perez-Castillo, A. (2005). Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. The Journal of biological chemistry. https://doi.org/10.1074/jbc.m414390200

Vancouver

Luna-Medina R, Cortes-Canteli M, Alonso M, Santos A, Martínez A, Perez-Castillo A. Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. The Journal of biological chemistry. 2005. doi:10.1074/jbc.m414390200. PMID: 15817469.

BibTeX

@article{lunamedina2005-15817469,
  author  = {Luna-Medina, R. and Cortes-Canteli, M. and Alonso, M. and Santos, A. and Martínez, A. and Perez-Castillo, A.},
  title   = {{Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m414390200},
  pmid    = {15817469},
  url     = {https://doi.org/10.1074/jbc.m414390200}
}

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How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Current treatments for these diseases are not effective.
In the present study we investigate the effect of thiadiazolidinone derivatives, which have been recently suggested to play a role in neurodegenerative disorders.
We have found that thiadiazolidinones are potent neuroprotector compounds.
Thiadiazolidinones inhibited inflammatory activation of cultured brain astrocytes and microglia by diminishing lipopolysaccharide-induced interleukin 6, tumor necrosis factor alpha, inducible nitric-oxide synthase, and inducible cyclooxygenase type 2 expression.

Why it matters

In cultured brain astrocytes and microglia, thiadiazolidinone derivatives inhibited inflammatory activation by diminishing lipopolysaccharide-induced interleukin 6, tumor necrosis factor alpha, and inducible nitric oxide synthase. This is an in vitro study, so it does not establish a treatment or cure for Alzheimer's disease.

Study details

Evidence strengthLow

How this study scored 42/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (The Journal of biological chemistry)
Journal's citation record	4 / 4	Journal of Biological Chemistry: journal h-index 780 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2005 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Laboratory or animal study (title names “in vitro”) — scores zero
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 190 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	8.3 citations a year over 23 year(s) since 2005
Impact for its field and year	3 / 6	Cited 7.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	1 / 6	Cited by 1 other studies in this library
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Ana Pérez‐Castillo: h-index 41 (OpenAlex, whole career)
Institution's track record	1 / 3	Consejo Superior de Investigaciones Científicas: institution h-index 1,048 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 15817469)
Free to read	0 / 2	Behind a paywall — scores zero
Total	42 / 100	—

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