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Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury
Faden AI, Wu J, Stoica BA, Loane DJ.. British journal of pharmacology, 2015-06-12
Topic: Brain proteins, microglia and lab models
Traumatic brain injury (TBI) has been linked to dementia and chronic neurodegeneration. Described initially in boxers and currently recognized across high contact sports, the association between repeated concussion (mild TBI) and progressive neuropsychiatric abnormalities has recently received widespread attention, and has been termed chronic traumatic encephalopathy. Less well appreciated are cognitive changes associated with neurodegeneration in the brain after isolated spinal cord injury.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Faden, A. I., Wu, J., Stoica, B. A., & Loane, D. J. (2016). Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury. British journal of pharmacology. https://doi.org/10.1111/bph.13179
Vancouver
Faden AI, Wu J, Stoica BA, Loane DJ. Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury. British journal of pharmacology. 2016. doi:10.1111/bph.13179. PMID: 25939377.
BibTeX
@article{faden2016-25939377,
author = {Faden, A. I. and Wu, J. and Stoica, B. A. and Loane, D. J.},
title = {{Progressive inflammation-mediated neurodegeneration after traumatic brain or spinal cord injury}},
journal = {British journal of pharmacology},
year = {2016},
doi = {10.1111/bph.13179},
pmid = {25939377},
url = {https://doi.org/10.1111/bph.13179}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Described initially in boxers and currently recognized across high contact sports, the association between repeated concussion (mild TBI) and progressive neuropsychiatric abnormalities has recently received widespread attention, and has been termed chronic traumatic encephalopathy.
- Less well appreciated are cognitive changes associated with neurodegeneration in the brain after isolated spinal cord injury.
- Also under-recognized is the role of sustained neuroinflammation after brain or spinal cord trauma, even though this relationship has been known since the 1950s and is supported by more recent preclinical and clinical studies.
- These pathological mechanisms, manifested by extensive microglial and astroglial activation and appropriately termed chronic traumatic brain inflammation or chronic traumatic inflammatory encephalopathy, may be among the most important causes of post-traumatic neurodegeneration in terms of prevalence.
Why it matters
This review discusses links between traumatic brain or spinal cord injury, sustained neuroinflammation and progressive neurodegeneration, including chronic traumatic encephalopathy. It does not report a treatment or cure for Alzheimer's disease.
Study details
- Evidence strengthLow
How this study scored 44/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (British journal of pharmacology) |
| Journal's citation record | 3 / 4 | British Journal of Pharmacology: journal h-index 319 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 286 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 23.8 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 11.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 62 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author David J. Loane: h-index 57 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Maryland, Baltimore: institution h-index 970 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25939377) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 44 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1111/bph.13179
- PubMed: 25939377
- Original source →
- Free full text: British Journal of Pharmacology →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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