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Ophthalmologic manifestations of Alzheimer's disease
Katz B, Rimmer S.. Survey of ophthalmology, 1989-07-01
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Alzheimer's disease is a progressive neurologic disorder which may present with visual disturbance before the diagnosis is clearly established. Central acuity and visual field are initially normal. Alzheimer patients may show anomalies of color vision, spatial contrast sensitivity, susceptibility to visual masks, fundus examination, ocular motility, higher cortical visual function, visual evoked potential, and pattern electroretinogram. Pathologic analysis has shown abnormalities at all levels of the visual axis from retinal ganglion cell to associative visual cortex. Correlations between the visual abnormalities of Alzheimer's disease and corresponding neuroanatomic substrates are discussed.
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APA 7th
Katz, B., & Rimmer, S. (1989). Ophthalmologic manifestations of Alzheimer's disease. Survey of ophthalmology. https://doi.org/10.1016/0039-6257(89)90127-6
Vancouver
Katz B, Rimmer S. Ophthalmologic manifestations of Alzheimer's disease. Survey of ophthalmology. 1989. doi:10.1016/0039-6257(89)90127-6. PMID: 2678551.
BibTeX
@article{katz1989-2678551,
author = {Katz, B. and Rimmer, S.},
title = {{Ophthalmologic manifestations of Alzheimer's disease}},
journal = {Survey of ophthalmology},
year = {1989},
doi = {10.1016/0039-6257(89)90127-6},
pmid = {2678551},
url = {https://doi.org/10.1016/0039-6257(89)90127-6}
}
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Key findings
- Alzheimer's disease is a progressive neurologic disorder which may present with visual disturbance before the diagnosis is clearly established.
- Central acuity and visual field are initially normal.
- Alzheimer patients may show anomalies of color vision, spatial contrast sensitivity, susceptibility to visual masks, fundus examination, ocular motility, higher cortical visual function, visual evoked potential, and pattern electroretinogram.
- Pathologic analysis has shown abnormalities at all levels of the visual axis from retinal ganglion cell to associative visual cortex.
- Correlations between the visual abnormalities of Alzheimer's disease and corresponding neuroanatomic substrates are discussed.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Survey of ophthalmology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1989 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 2678551) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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