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Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment
Catherine E Munro, Nancy J Donovan, Brendan J Guercio, Sarah E Wigman, Aaron P Schultz, Rebecca E Amariglio, Dorene M Rentz, Keith A Johnson et al.. Journal of Alzheimer's disease : JAD, 2015
Topic: Brain imaging, connectivity and assessment
There was a significant association between greater Affective factor symptoms and reduced FPCN connectivity (p = 0.03). There was no association between the Hyperactivity factor and any of the networks. Secondary analyses revealed an association between greater apathy and reduced FPCN connectivity (p = 0.005), but none in other networks. Decreased connectivity in the FPCN may be associated with greater affective symptoms, particularly apathy, early in AD. These findings extend prior studies, using different functional imaging modalities in individuals with greater disease severity.
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APA 7th
Munro, C. E., Donovan, N. J., Guercio, B. J., Wigman, S. E., Schultz, A. P., Amariglio, R. E., et al. (2015). Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-150017
Vancouver
Munro CE, Donovan NJ, Guercio BJ, Wigman SE, Schultz AP, Amariglio RE, et al. Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. 2015. doi:10.3233/jad-150017. PMID: 25854929.
BibTeX
@article{munro2015-25854929,
author = {Munro, Catherine E and Donovan, Nancy J and Guercio, Brendan J and Wigman, Sarah E and Schultz, Aaron P and Amariglio, Rebecca E and Rentz, Dorene M and Johnson, Keith A and others},
title = {{Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2015},
doi = {10.3233/jad-150017},
pmid = {25854929},
url = {https://doi.org/10.3233/jad-150017}
}
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Key findings
- There was a significant association between greater Affective factor symptoms and reduced FPCN connectivity (p = 0.03).
- There was no association between the Hyperactivity factor and any of the networks.
- Secondary analyses revealed an association between greater apathy and reduced FPCN connectivity (p = 0.005), but none in other networks.
- Decreased connectivity in the FPCN may be associated with greater affective symptoms, particularly apathy, early in AD.
- These findings extend prior studies, using different functional imaging modalities in individuals with greater disease severity.
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Study details
- Participants42
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 42 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25854929) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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