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Multiple Ischemic Strokes in a Patient Treated with Lecanemab: A Case Report
Alammar H, Llano DA.. Research Square, 2025-01-28
Topic: Brain proteins, microglia and lab models
Abstract Background Amyloid-lowering therapy has been previously associated with the formation of cerebral edema and/or microhemorrhage, often picked up on MRI and referred to as amyloid-related imaging abnormalities, or ARIA. Case presentation: We describe a case of a patient with Alzheimer’s Disease treated with the amyloid-lowering drug lecanemab who developed both ARIA-H and ARIA-E, and multiple ischemic infarctions. Conclusion This finding, in conjunction with previous reports of ischemic infarction in the setting of anti-amyloid therapy, suggests that amyloid-lowering therapy may predispose individuals to both hemorrhagic and ischemic infarction. This result is discussed in the context of microvascular pathology known to occur in the setting of Alzheimer’s Disease.
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APA 7th
Alammar, H., & Llano, D. A. (2025). Multiple Ischemic Strokes in a Patient Treated with Lecanemab: A Case Report. Research Square. https://doi.org/10.21203/rs.3.rs-5845699/v1
Vancouver
Alammar H, Llano DA. Multiple Ischemic Strokes in a Patient Treated with Lecanemab: A Case Report. Research Square. 2025. doi:10.21203/rs.3.rs-5845699/v1.
BibTeX
@article{alammar2025-77a96126,
author = {Alammar, H. and Llano, D. A.},
title = {{Multiple Ischemic Strokes in a Patient Treated with Lecanemab: A Case Report}},
journal = {Research Square},
year = {2025},
doi = {10.21203/rs.3.rs-5845699/v1},
url = {https://doi.org/10.21203/rs.3.rs-5845699/v1}
}
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Key findings
- Abstract Background Amyloid-lowering therapy has been previously associated with the formation of cerebral edema and/or microhemorrhage, often picked up on MRI and referred to as amyloid-related imaging abnormalities, or ARIA.
- Conclusion This finding, in conjunction with previous reports of ischemic infarction in the setting of anti-amyloid therapy, suggests that amyloid-lowering therapy may predispose individuals to both hemorrhagic and ischemic infarction.
- This result is discussed in the context of microvascular pathology known to occur in the setting of Alzheimer’s Disease.
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Study details
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 19 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 12 of the 62 points we could judge it on, which is 19 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Research Square) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 12 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 12 of the 62 points we could judge it on is 19 out of 100. |
| Total | 19 / 100 | Capped to 16 because this is not a peer-reviewed article. |
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