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Metformin use and brain atrophy in nondemented elderly individuals with diabetes
Fardin Nabizadeh, Samuel Berchi Kankam, Mohammad Balabandian, Seyedeh Melika Hashemi, Hossein Sharifkazemi, Mohammad Reza Rostami, Alzheimer's disease Neuroimaging Initiative (ADNI). Experimental gerontology, 2022-07-14
Topic: Drug trials: efficacy and safety
Among 157 subjects with a mean age of 71.8 (±7.7) included in this study, 76 individuals were stratified as metformin users. Results of the univariate model indicate that metformin users had a higher right (p = 0.003) and left parietal lobe volume (p = 0.004). Moreover, the volume of left cingulate was higher in those who used metformin compared to those not used it (p = 0.027). Our results were also significant for the right frontal lobe and indicated that metformin users had higher volume (p = 0.035). There were no significant differences in the hippocampus, occipital, and temporal regions. Our findings showed the protective effects of metformin on brain volumes in non-demented elderly individuals with diabetes. Comparing the groups show strong enough results regarding the lower atrophy in metformin users.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Nabizadeh, F., Kankam, S. B., Balabandian, M., Hashemi, S. M., Sharifkazemi, H., & Rostami, M. R. (2022). Metformin use and brain atrophy in nondemented elderly individuals with diabetes. Experimental gerontology. https://doi.org/10.1016/j.exger.2022.111890
Vancouver
Nabizadeh F, Kankam SB, Balabandian M, Hashemi SM, Sharifkazemi H, Rostami MR. Metformin use and brain atrophy in nondemented elderly individuals with diabetes. Experimental gerontology. 2022. doi:10.1016/j.exger.2022.111890. PMID: 35843348.
BibTeX
@article{nabizadeh2022-35843348,
author = {Nabizadeh, Fardin and Kankam, Samuel Berchi and Balabandian, Mohammad and Hashemi, Seyedeh Melika and Sharifkazemi, Hossein and Rostami, Mohammad Reza},
title = {{Metformin use and brain atrophy in nondemented elderly individuals with diabetes}},
journal = {Experimental gerontology},
year = {2022},
doi = {10.1016/j.exger.2022.111890},
pmid = {35843348},
url = {https://doi.org/10.1016/j.exger.2022.111890}
}
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Key findings
- Among 157 subjects with a mean age of 71.8 (±7.7) included in this study, 76 individuals were stratified as metformin users.
- Results of the univariate model indicate that metformin users had a higher right (p = 0.003) and left parietal lobe volume (p = 0.004).
- Moreover, the volume of left cingulate was higher in those who used metformin compared to those not used it (p = 0.027).
- Our results were also significant for the right frontal lobe and indicated that metformin users had higher volume (p = 0.035).
- There were no significant differences in the hippocampus, occipital, and temporal regions.
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Study details
- Participants157
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 28 of the 56 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Experimental gerontology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 157 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35843348) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 28 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 28 of the 56 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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