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Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings
Toledo JB, Bjerke M, Chen K, Rozycki M, Jack CR, Weiner MW, Arnold SE, Reiman EM et al.. Neurology, 2015-06-17
Topic: Risk, prevention and care in population studies
Objective We studied the biomarker signatures and prognoses of 3 different subtle cognitive impairment (SCI) groups (executive, memory, and multidomain) as well as the subjective memory complaints (SMC) group. Methods We studied 522 healthy controls in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Cutoffs for executive, memory, and multidomain SCI were defined using participants who remained cognitively normal (CN) for 7 years.
Key findings
- Methods We studied 522 healthy controls in the Alzheimer's Disease Neuroimaging Initiative (ADNI).
- Cutoffs for executive, memory, and multidomain SCI were defined using participants who remained cognitively normal (CN) for 7 years.
- CSF Alzheimer disease (AD) biomarkers, composite and region-of-interest (ROI) MRI, and fluorodeoxyglucose-PET measures were compared in these participants.
- Results Using a stringent cutoff (fifth percentile), 27.6% of the ADNI participants were classified as SCI.
Why it matters
This study looked at biomarker and prognosis patterns in groups with subtle cognitive impairment and subjective memory complaints among 522 healthy controls. It compared CSF Alzheimer's disease biomarkers, MRI, and FDG-PET measures across these groups.
Study details
- Participants522
- Effect size27.6%
- Evidence strengthLow
How this study scored 52/100
Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 522 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 47 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 3.6 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 3 / 6 | Cited 4.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Randall Griffith: h-index 49 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26085606) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 52 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1212/wnl.0000000000001738
- PubMed: 26085606
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Toledo, J. B., Bjerke, M., Chen, K., Rozycki, M., Jack, C. R., Weiner, M. W., et al. (2015). Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings. Neurology. https://doi.org/10.1212/wnl.0000000000001738
Vancouver
Toledo JB, Bjerke M, Chen K, Rozycki M, Jack CR, Weiner MW, et al. Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings. Neurology. 2015. doi:10.1212/wnl.0000000000001738. PMID: 26085606.
BibTeX
@article{toledo2015-26085606,
author = {Toledo, J. B. and Bjerke, M. and Chen, K. and Rozycki, M. and Jack, C. R. and Weiner, M. W. and Arnold, S. E. and Reiman, E. M. and others},
title = {{Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings}},
journal = {Neurology},
year = {2015},
doi = {10.1212/wnl.0000000000001738},
pmid = {26085606},
url = {https://doi.org/10.1212/wnl.0000000000001738}
}
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