Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease
Bin Zhang, Chris Gaiteri, Liviu‐Gabriel Bodea, Zhi Wang, Joshua J. McElwee, Alexei A. Podtelezhnikov, Chunsheng Zhang, Tao Xie, Linh My Tran, Radu Dobrin, Eugene M. Fluder, Bruce E. Clurman, Stacey Melquist, Manikandan Narayanan, Christine Suver, Hardik Shah, Milind C. Mahajan, Tammy Gillis, Jayalakshmi Srinidhi Mysore, Marcy E. MacDonald, John R. Lamb, David Alan Bennett, Cliona M. Molony, David J. Stone, Vilmundur G. Gudnason, Amanda Myers, Eric E. Schadt, Harald Neumann, Jun Zhu, Valur Emilsson. Cell, 2013-04-01
Topic: Amyloid, tau and blood-test diagnosis
The study constructed gene-regulatory networks in postmortem brain tissues from late-onset Alzheimer's disease patients and nondemented subjects to characterize associated molecular systems. By rank-ordering these network structures, the researchers highlighted an immune- and microglia-specific module containing TYROBP that is upregulated in the disease. Furthermore, experiments with mouse microglia cells overexpressing TYROBP revealed expression changes overlapping the human brain network, showing that the causal network structure predicts responses to gene perturbations.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zhang, B., Gaiteri, C., Bodea, L., Wang, Z., McElwee, J. J., Podtelezhnikov, A. A., et al. (2013). Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease. Cell. https://doi.org/10.1016/j.cell.2013.03.030
Vancouver
Zhang B, Gaiteri C, Bodea L, Wang Z, McElwee JJ, Podtelezhnikov AA, et al. Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease. Cell. 2013. doi:10.1016/j.cell.2013.03.030. PMID: 23622250.
BibTeX
@article{zhang2013-23622250,
author = {Zhang, Bin and Gaiteri, Chris and Bodea, Liviu‐Gabriel and Wang, Zhi and McElwee, Joshua J. and Podtelezhnikov, Alexei A. and Zhang, Chunsheng and Xie, Tao and Tran, Linh My and Dobrin, Radu and Fluder, Eugene M. and Clurman, Bruce E. and Melquist, Stacey and Narayanan, Manikandan and Suver, Christine and Shah, Hardik and Mahajan, Milind C. and Gillis, Tammy and Mysore, Jayalakshmi Srinidhi and MacDonald, Marcy E. and Lamb, John R. and Bennett, David Alan and Molony, Cliona M. and Stone, David J. and Gudnason, Vilmundur G. and Myers, Amanda and Schadt, Eric E. and Neumann, Harald and Zhu, Jun and Emilsson, Valur},
title = {{Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease}},
journal = {Cell},
year = {2013},
doi = {10.1016/j.cell.2013.03.030},
pmid = {23622250},
url = {https://doi.org/10.1016/j.cell.2013.03.030}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 30 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- LOAD reconfigures specific portions of the molecular interaction structure.
- Highlighting an immune- and microglia-specific module that is dominated by genes involved in pathogen phagocytosis, contains TYROBP as a key regulator, and is upregulated in LOAD.
- Mouse microglia cells overexpressing intact or truncated TYROBP revealed expression changes that significantly overlapped the human brain TYROBP network.
Why it matters
Uses an integrated systems approach to identify genetic nodes and networks in late-onset Alzheimer's disease.
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How this study scored 59/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 56 of the 95 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cell) |
| Journal's citation record | 4 / 4 | Cell: journal h-index 1,220 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,665 times (OpenAlex, 2026-10-10) |
| Citations per year | 5 / 5 | 111.0 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 6 / 6 | Cited 70.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 4 / 4 | Cited 287 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Valur Emilsson: h-index 56 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Massachusetts General Hospital: institution h-index 2,057 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 11 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23622250) |
| Free to read | 2 / 2 | Free to read |
| Points | 56 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 56 of the 95 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
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