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Enhanced Gamma Activity and Cross-Frequency Interaction of Resting-State Electroencephalographic Oscillations in Patients with Alzheimer's Disease
Wang J, Fang Y, Wang X, Yang H, Yu X, Wang H.. Frontiers in aging neuroscience, 2017-07-26
Topic: Amyloid, tau and blood-test diagnosis
Cognitive impairment, functional decline and behavioral symptoms that characterize Alzheimer's disease (AD) are associated with perturbations of the neuronal network. The typical electroencephalographic (EEG) features in AD patients are increased delta or theta rhythm and decreased alpha or beta rhythm activities. However, considering the role of cross-frequency couplings in cognition, the alternation of cross-frequency couplings in AD patients is still obscure. This study aims to explore the interaction dynamics between different EEG oscillations in AD patients. We recorded the resting eye-closed EEG signals in 8 AD patients and 12 healthy volunteers. By analyzing the wavelet power spectrum and bicoherence of EEG, we found enhanced gamma rhythm power in AD patients in addition to the increased delta and decreased alpha power. Furthermore, an enhancement of the cross-frequency coupling strength between the beta/gamma and low-frequency bands was observed in AD patients compared to healthy controls (HCs). We propose that the pathological increase of ongoing gamma-band power might result from the disruption of the GABAergic interneuron network in AD patients. Furthermore, the cross-frequency overcouplings, which reflect the enhanced synchronization, might indicate the attenuated complexity of the neuronal network, and AD patients have to use more neural resources to maintain the resting brain state. Overall, our findings provide new evidence of the disturbance of the brain oscillation network in AD and further deepen our understanding of the central mechanisms of AD.
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APA 7th
Wang, J., Fang, Y., Wang, X., Yang, H., Yu, X., & Wang, H. (2017). Enhanced Gamma Activity and Cross-Frequency Interaction of Resting-State Electroencephalographic Oscillations in Patients with Alzheimer's Disease. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2017.00243
Vancouver
Wang J, Fang Y, Wang X, Yang H, Yu X, Wang H. Enhanced Gamma Activity and Cross-Frequency Interaction of Resting-State Electroencephalographic Oscillations in Patients with Alzheimer's Disease. Frontiers in aging neuroscience. 2017. doi:10.3389/fnagi.2017.00243. PMID: 28798683.
BibTeX
@article{wang2017-28798683,
author = {Wang, J. and Fang, Y. and Wang, X. and Yang, H. and Yu, X. and Wang, H.},
title = {{Enhanced Gamma Activity and Cross-Frequency Interaction of Resting-State Electroencephalographic Oscillations in Patients with Alzheimer's Disease}},
journal = {Frontiers in aging neuroscience},
year = {2017},
doi = {10.3389/fnagi.2017.00243},
pmid = {28798683},
url = {https://doi.org/10.3389/fnagi.2017.00243}
}
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Key findings
- Cognitive impairment, functional decline and behavioral symptoms that characterize Alzheimer's disease (AD) are associated with perturbations of the neuronal network.
- By analyzing the wavelet power spectrum and bicoherence of EEG, we found enhanced gamma rhythm power in AD patients in addition to the increased delta and decreased alpha power.
- Furthermore, an enhancement of the cross-frequency coupling strength between the beta/gamma and low-frequency bands was observed in AD patients compared to healthy controls (HCs).
- We propose that the pathological increase of ongoing gamma-band power might result from the disruption of the GABAergic interneuron network in AD patients.
- Overall, our findings provide new evidence of the disturbance of the brain oscillation network in AD and further deepen our understanding of the central mechanisms of AD.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 24 of the 58 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28798683) |
| Free to read | 2 / 2 | Free to read |
| Points | 24 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 24 of the 58 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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