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Home › Research › Topics › interactions

interactions

6 studies tagged interactions, dated 2009-03-09 to 2020-12-01. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Alzheimer's Aβ42 and Aβ40 form mixed oligomers with direct molecular interactions 2020-12-01
  2. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production 2017-02-13
  3. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta 2016-03-31

Studies

6 studies carry this tag.

Date range

2009 to 2020

Top journals

  • BMC biology 1
  • Biochemical and biophysical research communications 1
  • Biochimica et biophysica acta 1
  • Molecular and cellular neurosciences 1
  • Molecular neurodegeneration 1

6 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Alzheimer's Aβ42 and Aβ40 form mixed oligomers with direct molecular interactions

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Biochemical and biophysical research communications 2020-12-01 Biomarkers

    Formation of Aβ oligomers and fibrils plays a central role in the pathogenesis of Alzheimer's disease.

  2. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2017-02-13 Biomarkers

    We demonstrate that targeted inhibition of the PS1-Syt1 binding in neurons, without changing the proteins' expression level, triggers "pathogenic" conformational shift of PS1, and consequent increase in the Aβ42/40 ratio.

  3. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. BMC biology 2016-03-31 Biomarkers

    Our findings identify Syt1 as a novel Ca(2+)-sensitive PS1 modulator that could regulate synaptic Aβ, opening avenues for novel and selective synapse targeting therapeutic strategies.

  4. Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2012-03-30 Biomarkers

    Gradual saturation of γ-secretase with its substrate can be the pathogenic process in different alleged causes of AD.

  5. Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2011-11-23 Biomarkers

    The association between apolipoprotein E (apoE) and amyloid-β peptide (Aβ) may significantly impact the function of both proteins, thus affecting the etiology of Alzheimer's disease (AD).

  6. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Molecular and cellular neurosciences 2009-03-09 Biomarkers

    Alzheimer's disease is characterized by accumulation of toxic beta-amyloid (Abeta) in the brain and neuronal death.

All topic tags with their study counts