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Effects of postoperative cognitive training on neurocognitive decline after heart surgery: a randomized clinical trial
Butz M, Gerriets T, Sammer G, El-Shazly J, Tschernatsch M, Huttner HB, Braun T, Boening A et al.. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2022-10-01
Topic: Risk, prevention and care in population studies
Objectives Following cardiac surgery, postoperative cognitive decline (POCD) is a common complication that can impair the quality of life and increase mortality. The aim of this study was to investigate whether early postoperative cognitive training can decrease POCD after cardiac surgery. Methods The study was a multi-centred, two-arm, randomized (1:1 ratio), controlled trial involving older patients undergoing elective heart valve surgery with extracorporeal circulation. Recruitment took place at the Department of Cardiac Surgery of the Kerckhoff-Clinic in Bad Nauheim (Germany) and the University-Hospital in Giessen (Germany). The patients were randomized to either a paper-and-pencil-based cognitive training group or a standard rehabilitation care control group. The cognitive training started 1 week after surgery and lasted about 3 weeks until discharge from rehabilitation. To detect POCD, neuropsychological functions were assessed prior to surgery, upon discharge from rehabilitation (primary outcome), and 3 months after discharge (secondary outcome). Data were primarily analysed in a per-protocol fashion. Results The frequency of POCD at discharge from rehabilitation (training group, n = 37; control group, n = 44) was 50% in the control group and 19% in the training group (χ2[1] = 8.45, P = 0.004; odds ratio = 4.29, 95% confidence interval [1.56-11.80]). Three months after the cognitive training (training group, n = 33; control group, n = 34), POCD frequency was 29% in the control group and 6% in the training group (χ2[1] = 6.21, P = 0.013; odds ratio = 6.46, 95% confidence interval [1.29-32.28]). Conclusions Since our cognitive training showed beneficial effects, it could be a promising method to prevent POCD.
Key findings
- Results The frequency of POCD at discharge from rehabilitation (training group, n = 37; control group, n = 44) was 50% in the control group and 19% in the training group (χ2[1] = 8.45, P = 0.004; odds ratio = 4.29, 95% confidence interval [1.56-11.80]).
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Study details
- Participants37
- Evidence strengthHigh
How this study scored 74/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record and institution's track record, so those were left out: it earned 45 of the 61 points we could judge it on, which is 74 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 37 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35415742) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 45 / 61 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 45 of the 61 points we could judge it on is 74 out of 100. |
| Total | 74 / 100 | — |
What each of these 20 components measures, and what this score is not →
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APA 7th
Butz, M., Gerriets, T., Sammer, G., El-Shazly, J., Tschernatsch, M., Huttner, H. B., et al. (2022). Effects of postoperative cognitive training on neurocognitive decline after heart surgery: a randomized clinical trial. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. https://doi.org/10.1093/ejcts/ezac251
Vancouver
Butz M, Gerriets T, Sammer G, El-Shazly J, Tschernatsch M, Huttner HB, et al. Effects of postoperative cognitive training on neurocognitive decline after heart surgery: a randomized clinical trial. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2022. doi:10.1093/ejcts/ezac251. PMID: 35415742.
BibTeX
@article{butz2022-35415742,
author = {Butz, M. and Gerriets, T. and Sammer, G. and El-Shazly, J. and Tschernatsch, M. and Huttner, H. B. and Braun, T. and Boening, A. and others},
title = {{Effects of postoperative cognitive training on neurocognitive decline after heart surgery: a randomized clinical trial}},
journal = {European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery},
year = {2022},
doi = {10.1093/ejcts/ezac251},
pmid = {35415742},
url = {https://doi.org/10.1093/ejcts/ezac251}
}
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