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early
4 studies tagged early, dated 2015-01-01 to 2024-06-28. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer's disease 2024-06-28
- Population pharmacokinetic-pharmacodynamic analyses of amyloid positron emission tomography and plasma biomarkers for lecanemab in subjects with early Alzheimer's disease 2022-09-27
- Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease 2015-10-01
Studies
4 studies carry this tag.
Date range
2015 to 2024
Top journals
- Alzheimer's & dementia : the journal of the Alzheimer's Association 1
- CPT: pharmacometrics & systems pharmacology 1
- JAMA neurology 1
- Journal of Parkinson's disease 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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55/100
Models integrating pTau217R outperformed Aβ42/Aβ40 alone, predicting amyloid levels up to 89.1 CL.
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Lecanemab is a humanized immunoglobulin G1 monoclonal antibody that selectively binds to soluble Aβ aggregate species, while demonstrating low affinity for Aβ monomer.
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64/100
Among the 128 study participants, the 104 patients with early PD had a different CSF pattern compared with the 13 patients with progressive supranuclear palsy (baseline area under the receiver operating characteristic curve, 0.87; P < .0001) and the 30 control participants (baseline area under the receiver operating characteristic curve, 0.69; P = .0021).
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The association between reduced CSF α-synuclein concentrations and cognition suggests that α-synuclein pathology contributes to early cognitive impairment in PD, in particular to executive-attentional dysfunction.