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Disruption of the hippocampal and hypothalamic blood-brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate
Salameh TS, Mortell WG, Logsdon AF, Butterfield DA, Banks WA.. Fluids and barriers of the CNS, 2019-01-08
Topic: Brain proteins, microglia and lab models
Plain-language summary
Background Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Topiramate administration was compared to saline controls in both preventative and efficacy arms examining BRB and BBB disruption. Results High-fat feeding caused increased entry of 14 C-sucrose and 99m Tc-albumin into the brains of diet-induced obese type II diabetic mice. In the retina, we observed increased entry of 99m Tc-albumin simultaneously with increased entry into the whole brain during the preventative arm.
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APA 7th
Salameh, T. S., Mortell, W. G., Logsdon, A. F., Butterfield, D. A., & Banks, W. A. (2019). Disruption of the hippocampal and hypothalamic blood-brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate. Fluids and barriers of the CNS. https://doi.org/10.1186/s12987-018-0121-6
Vancouver
Salameh TS, Mortell WG, Logsdon AF, Butterfield DA, Banks WA. Disruption of the hippocampal and hypothalamic blood-brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate. Fluids and barriers of the CNS. 2019. doi:10.1186/s12987-018-0121-6. PMID: 30616618.
BibTeX
@article{salameh2019-30616618,
author = {Salameh, T. S. and Mortell, W. G. and Logsdon, A. F. and Butterfield, D. A. and Banks, W. A.},
title = {{Disruption of the hippocampal and hypothalamic blood-brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate}},
journal = {Fluids and barriers of the CNS},
year = {2019},
doi = {10.1186/s12987-018-0121-6},
pmid = {30616618},
url = {https://doi.org/10.1186/s12987-018-0121-6}
}
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Key findings
- Background Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia.
- Topiramate administration was compared to saline controls in both preventative and efficacy arms examining BRB and BBB disruption.
- Results High-fat feeding caused increased entry of 14 C-sucrose and 99m Tc-albumin into the brains of diet-induced obese type II diabetic mice.
- In the retina, we observed increased entry of 99m Tc-albumin simultaneously with increased entry into the whole brain during the preventative arm.
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Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 24 of the 58 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Fluids and barriers of the CNS) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30616618) |
| Free to read | 2 / 2 | Free to read |
| Points | 24 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 24 of the 58 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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