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Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy
Julia A. Nadtochy, Sergey P. Medvedev, Elena V. Grigor’eva, Sophia V. Pavlova, Julia M. Minina, Anton V. Chechushkov, Anastasia A. Malakhova, Л. В. Коваленко et al.. Biomedicines, 2025-02-21
Topic: Brain proteins, microglia and lab models
Transgenic iPSC lines provide a unique tool to study the molecular and genetic mechanisms of FTDP-17 caused by the presence of the c.2013T > G (p.N279K) mutation, as well as to test potential drugs in vitro.
Key findings
- Transgenic iPSC lines provide a unique tool to study the molecular and genetic mechanisms of FTDP-17 caused by the presence of the c.2013T > G (p.N279K) mutation, as well as to test potential drugs in vitro.
Why it matters
This describes transgenic induced pluripotent stem cell lines created to study the molecular and genetic mechanisms of FTDP-17 caused by a specific mutation. The lines are a tool for in vitro study and drug testing, not a treatment or cure.
Study details
- Evidence strengthLow
How this study scored 38/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Biomedicines) |
| Journal's citation record | 1 / 4 | Biomedicines: journal h-index 133 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “transgenic”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 5 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 2.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 5 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Suren M. Zakian: h-index 26 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Russian Academy of Sciences: institution h-index 720 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40149527) |
| Free to read | 2 / 2 | Free to read |
| Total | 38 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Nadtochy, J. A., Medvedev, S. P., Grigor’eva, E. V., Pavlova, S. V., Minina, J. M., Chechushkov, A. V., et al. (2025). Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy. Biomedicines. https://doi.org/10.3390/biomedicines13030550
Vancouver
Nadtochy JA, Medvedev SP, Grigor’eva EV, Pavlova SV, Minina JM, Chechushkov AV, et al. Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy. Biomedicines. 2025. doi:10.3390/biomedicines13030550. PMID: 40149527.
BibTeX
@article{nadtochy2025-40149527,
author = {Nadtochy, Julia A. and Medvedev, Sergey P. and Grigor’eva, Elena V. and Pavlova, Sophia V. and Minina, Julia M. and Chechushkov, Anton V. and Malakhova, Anastasia A. and Коваленко, Л. В. and others},
title = {{Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy}},
journal = {Biomedicines},
year = {2025},
doi = {10.3390/biomedicines13030550},
pmid = {40149527},
url = {https://doi.org/10.3390/biomedicines13030550}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
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