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Diagnostic Performance and Clinical Applicability of Blood-Based Biomarkers in a Prospective Memory Clinic Cohort
Sarto J, Ruiz-García R, Guillén N, Ramos-Campoy Ó, Falgàs N, Esteller D, Contador J, Fernández G et al.. Neurology, 2022-11-30
Topic: Risk, prevention and care in population studies
Performance was assessed in comparison to clinical diagnosis (blinded to plasma results) and amyloid status (CSF/PET). Results Three hundred forty-nine participants (mean age 68, SD 8.3 years) and 36 CU controls (mean age 61.7, SD 8.2 years) were included. In the subcohort without AD biomarkers, similar results were obtained. However, the 14% false-negative results suggest that further improvement is needed before implementation outside memory clinics.
Key findings
- Performance was assessed in comparison to clinical diagnosis (blinded to plasma results) and amyloid status (CSF/PET).
- Results Three hundred forty-nine participants (mean age 68, SD 8.3 years) and 36 CU controls (mean age 61.7, SD 8.2 years) were included.
- In the subcohort without AD biomarkers, similar results were obtained.
- However, the 14% false-negative results suggest that further improvement is needed before implementation outside memory clinics.
Why it matters
This study assessed blood-based biomarkers in a memory clinic cohort and found that 14% false-negative results mean further improvement is needed before use outside memory clinics. It is a diagnostic study and does not report any treatment, cure, or prevention of Alzheimer's disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Participants268
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal. Scored zero for study design and effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 268 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Blinded or placebo-controlled (as stated in the record) |
| Times cited | 4 / 7 | Cited 72 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.4 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 4 / 6 | Cited 8.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 3 / 4 | Cited 61 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Mircea Balasa: h-index 41 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of California, San Francisco: institution h-index 1,915 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36450604) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1212/wnl.0000000000201597
- PubMed: 36450604
- Original source →
- Free full text: PubMed Central →
Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Sarto, J., Ruiz-García, R., Guillén, N., Ó, R.-C., Falgàs, N., Esteller, D., et al. (2023). Diagnostic Performance and Clinical Applicability of Blood-Based Biomarkers in a Prospective Memory Clinic Cohort. Neurology. https://doi.org/10.1212/wnl.0000000000201597
Vancouver
Sarto J, Ruiz-García R, Guillén N, Ó R.-C, Falgàs N, Esteller D, et al. Diagnostic Performance and Clinical Applicability of Blood-Based Biomarkers in a Prospective Memory Clinic Cohort. Neurology. 2023. doi:10.1212/wnl.0000000000201597. PMID: 36450604.
BibTeX
@article{sarto2023-36450604,
author = {Sarto, J. and Ruiz-García, R. and Guillén, N. and Ó, Ramos-Campoy and Falgàs, N. and Esteller, D. and Contador, J. and Fernández, G. and others},
title = {{Diagnostic Performance and Clinical Applicability of Blood-Based Biomarkers in a Prospective Memory Clinic Cohort}},
journal = {Neurology},
year = {2023},
doi = {10.1212/wnl.0000000000201597},
pmid = {36450604},
url = {https://doi.org/10.1212/wnl.0000000000201597}
}
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