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Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum
Alty J, Goldberg LR, Roccati E, Lawler K, Bai Q, Huang G, Bindoff AD, Li R et al.. BMC neurology, 2024-04-16
Topic: Amyloid, tau and blood-test diagnosis
Motor measures will be compared to a blood-based AD biomarker, phosphorylated tau 181 to develop an algorithm that classifies preclinical AD risk.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Alty, J., Goldberg, L. R., Roccati, E., Lawler, K., Bai, Q., Huang, G., et al. (2024). Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum. BMC neurology. https://doi.org/10.1186/s12883-024-03609-z
Vancouver
Alty J, Goldberg LR, Roccati E, Lawler K, Bai Q, Huang G, et al. Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum. BMC neurology. 2024. doi:10.1186/s12883-024-03609-z. PMID: 38627686.
BibTeX
@article{alty2024-38627686,
author = {Alty, J. and Goldberg, L. R. and Roccati, E. and Lawler, K. and Bai, Q. and Huang, G. and Bindoff, A. D. and Li, R. and others},
title = {{Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum}},
journal = {BMC neurology},
year = {2024},
doi = {10.1186/s12883-024-03609-z},
pmid = {38627686},
url = {https://doi.org/10.1186/s12883-024-03609-z}
}
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Key findings
- Motor measures will be compared to a blood-based AD biomarker, phosphorylated tau 181 to develop an algorithm that classifies preclinical AD risk.
Study details
- Study designcohort study
- Participants1,382
- Effect size72.07%
- Evidence strengthModerate
How this study scored 74/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 43 of the 58 points we could judge it on, which is 74 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMC neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,382 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38627686) |
| Free to read | 2 / 2 | Free to read |
| Points | 43 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 43 of the 58 points we could judge it on is 74 out of 100. |
| Total | 74 / 100 | — |
What each of these 20 components measures, and what this score is not →
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