Home › Research › Biomarkers
Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease
Celebi O, Uzdogan A, Oguz KK, Has AC, Dolgun A, Cakmakli GY, Akbiyik F, Elibol B et al.. Archives of gerontology and geriatrics, 2015-10-17
Topic: Amyloid, tau and blood-test diagnosis
Background Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology. Methods Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls. Results DMN activity is altered in AD. Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores. The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD. Conclusions The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Celebi, O., Uzdogan, A., Oguz, K. K., Has, A. C., Dolgun, A., Cakmakli, G. Y., et al. (2016). Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease. Archives of gerontology and geriatrics. https://doi.org/10.1016/j.archger.2015.09.010
Vancouver
Celebi O, Uzdogan A, Oguz KK, Has AC, Dolgun A, Cakmakli GY, et al. Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease. Archives of gerontology and geriatrics. 2016. doi:10.1016/j.archger.2015.09.010. PMID: 26515126.
BibTeX
@article{celebi2016-26515126,
author = {Celebi, O. and Uzdogan, A. and Oguz, K. K. and Has, A. C. and Dolgun, A. and Cakmakli, G. Y. and Akbiyik, F. and Elibol, B. and others},
title = {{Default mode network connectivity is linked to cognitive functioning and CSF Aβ1-42 levels in Alzheimer's disease}},
journal = {Archives of gerontology and geriatrics},
year = {2016},
doi = {10.1016/j.archger.2015.09.010},
pmid = {26515126},
url = {https://doi.org/10.1016/j.archger.2015.09.010}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Background Changes in the default mode network (DMN) activity are early features of Alzheimer's disease (AD) and may be linked to AD-specific Aβ pathology.
- Methods Cognitive profiles; DMN connectivity alterations; and cerebrospinal fluid (CSF) amyloid beta (Aβ)1-42, total tau, phosphorylated tau 181, and α-synuclein levels were studied in 21 patients with AD and 10 controls.
- Posterior cingulate cortex (PCC) functional connectivity with other parts of DMN was related to cognitive function scores.
- The reduction of connectivity of the dorsal PCC with the retrosplenial cortex on the right side was closely related to decreased CSF Aβ1-42 levels in patients with AD.
- Conclusions The dorsal PCC and retrosplenial cortex may have special importance in the pathogenesis and cognitive findings of AD.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Participants21
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 25 of the 58 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of gerontology and geriatrics) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 21 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26515126) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 25 of the 58 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Related studies in Biomarkers
Also in Biomarkers
204 studies in the library are filed under Biomarkers with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Biomarkers hub.