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55/100

✓ Peer-reviewed alzhub usefulness score 55 out of 100. Tau biomarkers

Topic: Brain proteins, microglia and lab models

Importance With blood-based phosphorylated tau biomarkers soon to be used for diagnosis of Alzheimer disease, analyzing tau levels in other conditions could enhance biomarker interpretability. Moreover, mechanisms of tau release into circulation remain unclear. Objective To evaluate concentrations of phosphorylated and nonphosphorylated tau variants in the blood of patients with multiple traumatic injuries on days 0, 1, 5, and 10 and investigate biological processes driving tau release.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Halbgebauer, R., Gonzalez-Ortiz, F., Mayer, B., Berger, C., Bergmann, C., Rinderknecht, H., et al. (2026). Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2025.58573

Vancouver

Halbgebauer R, Gonzalez-Ortiz F, Mayer B, Berger C, Bergmann C, Rinderknecht H, et al. Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries. JAMA network open. 2026. doi:10.1001/jamanetworkopen.2025.58573. PMID: 41665901.

BibTeX

@article{halbgebauer2026-41665901,
  author  = {Halbgebauer, R. and Gonzalez-Ortiz, F. and Mayer, B. and Berger, C. and Bergmann, C. and Rinderknecht, H. and Barth, E. and Wohlgemuth, L. and others},
  title   = {{Blood-Based Analysis of Different Tau Variants in Patients With Multiple Traumatic Injuries}},
  journal = {JAMA network open},
  year    = {2026},
  doi     = {10.1001/jamanetworkopen.2025.58573},
  pmid    = {41665901},
  url     = {https://doi.org/10.1001/jamanetworkopen.2025.58573}
}

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Key findings

Moreover, mechanisms of tau release into circulation remain unclear.
Objective To evaluate concentrations of phosphorylated and nonphosphorylated tau variants in the blood of patients with multiple traumatic injuries on days 0, 1, 5, and 10 and investigate biological processes driving tau release.
Design, setting, and participants This multiple-trauma cohort (injury severity score, ≥18) included 45 severely injured patients with (n = 27) and without (n = 18) moderate-to-severe traumatic brain injury on emergency computed tomographic imaging.
Controls consisted of 24 healthy volunteers.

Why it matters

This study measured phosphorylated and nonphosphorylated tau variants in the blood of patients with multiple traumatic injuries to better understand what drives tau release into the blood. It concerns trauma, not Alzheimer's disease treatment, cure, or prevention.

New to this subject? Start with our plain-English guide: Blood tests & biomarkers →

Study details

Participants27
Effect size77.8%; 66.7%
Evidence strengthModerate

How this study scored 55/100

Published in a leading specialty journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA network open)
Journal's citation record	2 / 4	JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	1 / 4	27 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.5 citations a year over 2 year(s) since 2026
Impact for its field and year	4 / 6	Cited 13.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Kaj Blennow: h-index 220 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 13 institution(s) in 5 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41665901)
Free to read	2 / 2	Free to read
Total	55 / 100	—

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