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Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT)
Gottfries CG, Adolfsson R, Aquilonius SM, Carlsson A, Eckernäs SA, Nordberg A, Oreland L, Svennerholm L et al.. Neurobiology of aging, 1983-01-01
Topic: Amyloid, tau and blood-test diagnosis
In postmortem investigations of patients with dementia of Alzheimer type (AD/SDAT) (n = 14) the brain weight was significantly reduced when compared to controls (n = 16). In four AD/SDAT-brain parts investigated the concentrations of 5-hydroxy-tryptamine and noradrenaline were significantly reduced while 3-methoxy-4-hydroxyphenylglycol was significantly increased. In the caudate nucleus of the AD/SDAT-brains the concentrations of dopamine and homovanillic acid were significantly reduced.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Gottfries, C. G., Adolfsson, R., Aquilonius, S. M., Carlsson, A., Eckernäs, S. A., Nordberg, A., et al. (1983). Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT). Neurobiology of aging. https://doi.org/10.1016/0197-4580(83)90002-7
Vancouver
Gottfries CG, Adolfsson R, Aquilonius SM, Carlsson A, Eckernäs SA, Nordberg A, et al. Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT). Neurobiology of aging. 1983. doi:10.1016/0197-4580(83)90002-7. PMID: 6200784.
BibTeX
@article{gottfries1983-6200784,
author = {Gottfries, C. G. and Adolfsson, R. and Aquilonius, S. M. and Carlsson, A. and Eckernäs, S. A. and Nordberg, A. and Oreland, L. and Svennerholm, L. and others},
title = {{Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT)}},
journal = {Neurobiology of aging},
year = {1983},
doi = {10.1016/0197-4580(83)90002-7},
pmid = {6200784},
url = {https://doi.org/10.1016/0197-4580(83)90002-7}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- In four AD/SDAT-brain parts investigated the concentrations of 5-hydroxy-tryptamine and noradrenaline were significantly reduced while 3-methoxy-4-hydroxyphenylglycol was significantly increased.
- In the caudate nucleus of the AD/SDAT-brains the concentrations of dopamine and homovanillic acid were significantly reduced.
- The activity of monoamine oxidase B was increased suggesting a proliferation of extra neuronal tissue in the AD/SDAT-brains.
- The activity of choline acetyl transferase was reduced in the four brain parts investigated, showing a general reduction in the acetylcholine system in the AD/SDAT-brains.
Why it matters
This postmortem study of 14 patients with dementia of Alzheimer type found reduced brain weight and reduced concentrations of several neurotransmitters compared with 16 controls. It describes biochemical changes in the brain and reports no treatment, cure or prevention for Alzheimer's disease.
Study details
- Participants14
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1983 — older than 20 years, still counted |
| Sample size | 1 / 4 | 14 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 304 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.8 citations a year over 45 year(s) since 1983 |
| Impact for its field and year | 4 / 6 | Cited 17.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Bengt G. Winblad: h-index 171 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Uppsala University: institution h-index 1,114 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 6200784) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
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