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Hypercapnic and Hypoxic Respiratory Response During Wakefulness and Sleep in a Streptozotocin Model of Alzheimer's Disease in Rats
Vicente MC, Almeida MC, Bícego KC, Carrettiero DC, Gargaglioni LH.. Journal of Alzheimer's disease : JAD, 2018-01-01
Topic: Brain proteins, microglia and lab models
Besides the typical cognitive decline, patients with Alzheimer's disease (AD) develop disorders of the respiratory system, such as sleep apnea, shortness of breath, and arrhythmias. These symptoms are aggravated with the progression of the disease. However, the cause and nature of these disturbances are not well understood.
Key findings
- These symptoms are aggravated with the progression of the disease.
- However, the cause and nature of these disturbances are not well understood.
- Here, we treated animals with intracerebroventricular streptozotocin (STZ, 2 mg/kg), a drug that has been described to cause Alzheimer-like behavioral and histopathological impairments.
- We measured ventilation (V̇E), electroencephalography, and electromyography during normocapnia, hypercapnia, and hypoxia in Wistar rats.
Why it matters
Rats given streptozotocin into the brain, a model of Alzheimer-like changes, were studied for their breathing responses to high carbon dioxide and low oxygen while awake and asleep. This is animal research and does not establish any treatment for people.
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Study details
- Effect sizeincreased by 26%
- Evidence strengthLow
How this study scored 34/100
Published in a peer-reviewed journal. Scored zero for study design, sample size and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | 2 / 4 | Journal of Alzheimer s Disease: journal h-index 218 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2018 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rats”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 2 / 7 | Cited 12 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.2 citations a year over 10 year(s) since 2018 |
| Impact for its field and year | 1 / 6 | Cited 0.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 7 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Luciane H. Gargaglioni: h-index 27 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Universidade Estadual Paulista (Unesp): institution h-index 501 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30124447) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 34 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3233/jad-180397
- PubMed: 30124447
- Original source →
- Free full text: LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Vicente, M. C., Almeida, M. C., Bícego, K. C., Carrettiero, D. C., & Gargaglioni, L. H. (2018). Hypercapnic and Hypoxic Respiratory Response During Wakefulness and Sleep in a Streptozotocin Model of Alzheimer's Disease in Rats. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-180397
Vancouver
Vicente MC, Almeida MC, Bícego KC, Carrettiero DC, Gargaglioni LH. Hypercapnic and Hypoxic Respiratory Response During Wakefulness and Sleep in a Streptozotocin Model of Alzheimer's Disease in Rats. Journal of Alzheimer's disease : JAD. 2018. doi:10.3233/jad-180397. PMID: 30124447.
BibTeX
@article{vicente2018-30124447,
author = {Vicente, M. C. and Almeida, M. C. and Bícego, K. C. and Carrettiero, D. C. and Gargaglioni, L. H.},
title = {{Hypercapnic and Hypoxic Respiratory Response During Wakefulness and Sleep in a Streptozotocin Model of Alzheimer's Disease in Rats}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2018},
doi = {10.3233/jad-180397},
pmid = {30124447},
url = {https://doi.org/10.3233/jad-180397}
}
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Referenced by this study and also in the alzhub library, so you can read them here.