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Age-related and amyloid-beta-independent tau deposition and its downstream effects
Wuestefeld A, Pichet Binette A, Berron D, Spotorno N, van Westen D, Stomrud E, Mattsson-Carlgren N, Strandberg O et al.. Brain : a journal of neurology, 2023-08-01
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
In vivo age-related tau deposition was observed in the medial temporal lobe and in frontal and parietal cortical regions, which was statistically significant when adjusting for Aβ. Tau deposition was negatively associated with cortical volumes and thickness in temporal and parietal regions independently of Aβ. Results were validated in the ex vivo cohort showing age-related and Aβ-independent increases in tau aggregates in and outside the medial temporal lobe. Taken together, our study provides support for primary age-related tauopathy even outside the medial temporal lobe in vivo and ex vivo, with downstream effects on structure and cognition. These results have implications for our understanding of the spreading of tau outside the medial temporal lobe, also in the context of Alzheimer's disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wuestefeld, A., Pichet Binette, A., Berron, D., Spotorno, N., van Westen, D., Stomrud, E., et al. (2023). Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. https://doi.org/10.1093/brain/awad135
Vancouver
Wuestefeld A, Pichet Binette A, Berron D, Spotorno N, van Westen D, Stomrud E, et al. Age-related and amyloid-beta-independent tau deposition and its downstream effects. Brain : a journal of neurology. 2023. doi:10.1093/brain/awad135. PMID: 37082959.
BibTeX
@article{wuestefeld2023-37082959,
author = {Wuestefeld, A. and Pichet Binette, A. and Berron, D. and Spotorno, N. and van Westen, D. and Stomrud, E. and Mattsson-Carlgren, N. and Strandberg, O. and others},
title = {{Age-related and amyloid-beta-independent tau deposition and its downstream effects}},
journal = {Brain : a journal of neurology},
year = {2023},
doi = {10.1093/brain/awad135},
pmid = {37082959},
url = {https://doi.org/10.1093/brain/awad135}
}
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Key findings
- In vivo age-related tau deposition was observed in the medial temporal lobe and in frontal and parietal cortical regions, which was statistically significant when adjusting for Aβ.
- Tau deposition was negatively associated with cortical volumes and thickness in temporal and parietal regions independently of Aβ.
- Results were validated in the ex vivo cohort showing age-related and Aβ-independent increases in tau aggregates in and outside the medial temporal lobe.
- Taken together, our study provides support for primary age-related tauopathy even outside the medial temporal lobe in vivo and ex vivo, with downstream effects on structure and cognition.
- These results have implications for our understanding of the spreading of tau outside the medial temporal lobe, also in the context of Alzheimer's disease.
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Study details
- Participants545
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 34 of the 58 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Brain : a journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 545 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37082959) |
| Free to read | 2 / 2 | Free to read |
| Points | 34 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 34 of the 58 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
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