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Aducanumab and disease modifying treatments for Alzheimer's disease
Emily Thomas, Brenda Wasunna‐Smith, Tarun Kuruvilla. Progress in Neurology and Psychiatry, 2021-07
Topic: Drug trials: efficacy and safety
Plain-language summary
Aducanumab has recently been licensed by the Food and Drug Administration (FDA) in the USA under its ‘accelerated approval’ pathway (to provide earlier access to treatments that fulfil an unmet need based on a surrogate endpoint) for treatment of Alzheimer's disease. This was a controversial decision, and the licence is subject to the outcome of further phase IV trials. Results will be eagerly anticipated, especially by the estimated 50 billion people worldwide currently living with dementia. 1 The drugs success could pave the way for a new era in treatments at a time where existing therapies only offer symptomatic treatment to slow progression.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Thomas, E., Wasunna‐Smith, B., & Kuruvilla, T. (2021). Aducanumab and disease modifying treatments for Alzheimer's disease. Progress in Neurology and Psychiatry. https://doi.org/10.1002/pnp.711
Vancouver
Thomas E, Wasunna‐Smith B, Kuruvilla T. Aducanumab and disease modifying treatments for Alzheimer's disease. Progress in Neurology and Psychiatry. 2021. doi:10.1002/pnp.711.
BibTeX
@article{thomas2021-6ea281e6,
author = {Thomas, Emily and Wasunna‐Smith, Brenda and Kuruvilla, Tarun},
title = {{Aducanumab and disease modifying treatments for Alzheimer's disease}},
journal = {Progress in Neurology and Psychiatry},
year = {2021},
doi = {10.1002/pnp.711},
url = {https://doi.org/10.1002/pnp.711}
}
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Key findings
- Results will be eagerly anticipated, especially by the estimated 50 billion people worldwide currently living with dementia. 1 The drugs success could pave the way for a new era in treatments at a time where existing therapies only offer symptomatic treatment to slow progression.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Progress in Neurology and Psychiatry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
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