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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. TREM2 and immune genetics

Topic: Brain proteins, microglia and lab models

Background The activation of the immune system in neurodegeneration has detrimental as well as beneficial effects. Which aspects of this immune response aggravate the neurodegenerative breakdown and which stimulate regeneration remains an open question. To unravel the neuroprotective aspects of the immune system we focused on a model of acute peripheral nerve injury, in which the immune system was shown to be protective.

Key findings

Which aspects of this immune response aggravate the neurodegenerative breakdown and which stimulate regeneration remains an open question.
To unravel the neuroprotective aspects of the immune system we focused on a model of acute peripheral nerve injury, in which the immune system was shown to be protective.
Methods To determine the type of immune response triggered after axotomy of the sciatic nerve, a model for Wallerian degeneration in the peripheral nervous system, we evaluated markers representing the two extremes of a type I and type II immune response (classical vs. alternative) using real-time quantitative polymerase chain reaction (RT-qPCR), western blot, and immunohistochemistry.
Results Our results showed that acute peripheral nerve injury triggers an anti-inflammatory and immunosuppressive response, rather than a pro-inflammatory response.

Why it matters

This study examines the immune response after acute peripheral nerve injury in a Wallerian degeneration model. It concerns peripheral nerve injury, not Alzheimer's disease treatment or prevention.

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Study details

Evidence strengthLow

How this study scored 45/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of neuroinflammation)
Journal's citation record	2 / 4	Journal of Neuroinflammation: journal h-index 216 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2012 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 160 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.0 citations a year over 16 year(s) since 2012
Impact for its field and year	3 / 6	Cited 6.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	2 / 4	Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Sophie Janssens: h-index 49 (OpenAlex, whole career)
Institution's track record	1 / 3	Ghent University: institution h-index 1,033 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 22818207)
Free to read	2 / 2	Free to read
Total	45 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Ydens, E., Cauwels, A., Asselbergh, B., Goethals, S., Peeraer, L., Lornet, G., et al. (2012). Acute injury in the peripheral nervous system triggers an alternative macrophage response. Journal of neuroinflammation. https://doi.org/10.1186/1742-2094-9-176

Vancouver

Ydens E, Cauwels A, Asselbergh B, Goethals S, Peeraer L, Lornet G, et al. Acute injury in the peripheral nervous system triggers an alternative macrophage response. Journal of neuroinflammation. 2012. doi:10.1186/1742-2094-9-176. PMID: 22818207.

BibTeX

@article{ydens2012-22818207,
  author  = {Ydens, E. and Cauwels, A. and Asselbergh, B. and Goethals, S. and Peeraer, L. and Lornet, G. and Almeida-Souza, L. and Van Ginderachter, J. A. and others},
  title   = {{Acute injury in the peripheral nervous system triggers an alternative macrophage response}},
  journal = {Journal of neuroinflammation},
  year    = {2012},
  doi     = {10.1186/1742-2094-9-176},
  pmid    = {22818207},
  url     = {https://doi.org/10.1186/1742-2094-9-176}
}

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