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Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment
Bai F, Watson DR, Yu H, Shi Y, Yuan Y, Zhang Z.. Brain research, 2009-09-16
Topic: Brain proteins, microglia and lab models
Amnestic type mild cognitive impairment (aMCI) refers to a transitional stage between normal aging and Alzheimer's disease (AD). Whilst posterior cingulate cortex (PCC) is believed to have a key role in a default network and be involved in the pathophysiology of AD, few studies have investigated whole-brain functional connectivity of PCC during resting state, or investigated the relationship between abnormal functional connectivity and disturbance in cognitive function in aMCI patients. Resting-state functional connectivity analysis was used to examine the temporal correlation between PCC and whole-brain regions in 30 aMCI patients and 26 well-matched controls. Further analysis involved evaluation of possible relationships between functional connectivity measures and cognitive function. Regions of decreased functional connectivity were identified in aMCI patients, most notably in temporal cortex, whilst significantly increased functional connectivity was mainly in frontal cortex. In addition, functional connectivity of PCC and temporal cortex was associated with the performance of neuropsychological tests in aMCI patients. This would be consonant with the recruitment of compensatory mechanisms and the process of offset functional impairments appearing as neuropathologic develops, and resting-state connectivity disturbance of PCC-temporal cortex may be a central role in cognitive deficit in aMCI patients.
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APA 7th
Bai, F., Watson, D. R., Yu, H., Shi, Y., Yuan, Y., & Zhang, Z. (2009). Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment. Brain research. https://doi.org/10.1016/j.brainres.2009.09.028
Vancouver
Bai F, Watson DR, Yu H, Shi Y, Yuan Y, Zhang Z. Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment. Brain research. 2009. doi:10.1016/j.brainres.2009.09.028. PMID: 19765560.
BibTeX
@article{bai2009-19765560,
author = {Bai, F. and Watson, D. R. and Yu, H. and Shi, Y. and Yuan, Y. and Zhang, Z.},
title = {{Abnormal resting-state functional connectivity of posterior cingulate cortex in amnestic type mild cognitive impairment}},
journal = {Brain research},
year = {2009},
doi = {10.1016/j.brainres.2009.09.028},
pmid = {19765560},
url = {https://doi.org/10.1016/j.brainres.2009.09.028}
}
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Key findings
- Regions of decreased functional connectivity were identified in aMCI patients, most notably in temporal cortex, whilst significantly increased functional connectivity was mainly in frontal cortex.
- In addition, functional connectivity of PCC and temporal cortex was associated with the performance of neuropsychological tests in aMCI patients.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain research) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 19765560) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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