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A Novel Mouse Model for Investigating ARIAs in Response to Anti-Abeta Immunotherapy
Christian Crouzet, Jihua Liu, Bernard Choi, David H Cribbs. Cerebral Circulation - Cognition and Behavior, 2025-01-01
Topic: Amyloid, tau and blood-test diagnosis
Study 1 was designed for 8 weeks with weekly 3D6.IgG2a injections, but was aborted after the first injection when 7/10 mice died within 36 hours. The remaining 3 mice were perfused to salvage data. All 3D6.IgG2a-treated brains showed surface macro- hemorrhages (Figure 1), while the IgG2a controls had no visible bleeds. Study 2 revealed striking strain differences: 5XFAD.C57B/6J mice were resistant to 3D6.IgG2a at all timepoints, while 5XFAD.WSB.EiJ brains showed modest surface lesions at 12 hours, prominent hemorrhages by 24 hours, and distress signs by 27 hours. Conclusions Comparing anti-Ab immunotherapy responses between 5XFAD.C57B/6J versus 5XFAD.WSB.EiJ mice provide insights into aging, amyloid plaque, and CAA contributions to ARIA development. The 3D6 antibody was chosen because its humanized version (bapineuzumab) previously reduced Aβ pathology while inducing ARIA-E and ARIA-H in patients. ARIA-like responses in 5XFAD.WSB.EiJ mice may provide a valuable model for investigating causes of serious adverse events in human amyloid immunotherapy patients.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Crouzet, C., Liu, J., Choi, B., & Cribbs, D. H. (2025). A Novel Mouse Model for Investigating ARIAs in Response to Anti-Abeta Immunotherapy. Cerebral Circulation - Cognition and Behavior. https://doi.org/10.1016/j.cccb.2025.100475
Vancouver
Crouzet C, Liu J, Choi B, Cribbs DH. A Novel Mouse Model for Investigating ARIAs in Response to Anti-Abeta Immunotherapy. Cerebral Circulation - Cognition and Behavior. 2025. doi:10.1016/j.cccb.2025.100475.
BibTeX
@article{crouzet2025-ff920d55,
author = {Crouzet, Christian and Liu, Jihua and Choi, Bernard and Cribbs, David H},
title = {{A Novel Mouse Model for Investigating ARIAs in Response to Anti-Abeta Immunotherapy}},
journal = {Cerebral Circulation - Cognition and Behavior},
year = {2025},
doi = {10.1016/j.cccb.2025.100475},
url = {https://doi.org/10.1016/j.cccb.2025.100475}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Study 1 was designed for 8 weeks with weekly 3D6.IgG2a injections, but was aborted after the first injection when 7/10 mice died within 36 hours.
- The remaining 3 mice were perfused to salvage data.
- All 3D6.IgG2a-treated brains showed surface macro- hemorrhages (Figure 1), while the IgG2a controls had no visible bleeds.
- Study 2 revealed striking strain differences: 5XFAD.C57B/6J mice were resistant to 3D6.IgG2a at all timepoints, while 5XFAD.WSB.EiJ brains showed modest surface lesions at 12 hours, prominent hemorrhages by 24 hours, and distress signs by 27 hours.
- Conclusions Comparing anti-Ab immunotherapy responses between 5XFAD.C57B/6J versus 5XFAD.WSB.EiJ mice provide insights into aging, amyloid plaque, and CAA contributions to ARIA development.
Why it matters
In this mouse study, most mice given the anti-Abeta antibody 3D6.IgG2a died within 36 hours, and surviving treated brains showed surface macro-hemorrhages while controls had no visible bleeds. The authors propose a mouse strain as a possible model for studying ARIA, but this is animal research and provides no treatment or cure for patients.
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Study details
- Evidence strengthLow
How this study scored 28/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 27 of the 96 points we could judge it on, which is 28 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cerebral Circulation - Cognition and Behavior) |
| Journal's citation record | 0 / 4 | Cerebral Circulation - Cognition and Behavior: journal h-index 19 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mouse”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | 1 / 3 | University of California, Irvine: institution h-index 1,195 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 2 / 2 | Free to read |
| Points | 27 / 96 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 27 of the 96 points we could judge it on is 28 out of 100. |
| Total | 28 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1016/j.cccb.2025.100475
- Original source →
- Free full text: Cerebral Circulation - Cognition and Behavior →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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