Until recently, intraindividual visit-to-visit variability of cardiovascular risk factors has been dismissed as random fluctuation. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
31,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
39/100
Neurodegenerative disorders are the most devastating disorder of the nervous system. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Similar to other complex disorders, the etiology of Alzheimer disease is multifactorial and characterized by an interplay of biological and environmental risk and protective factors. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research into cognitive reserve (CR) and dementia is advancing rapidly. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Despite the large number of elderly bilinguals at risk for Alzheimer's disease (AD) and dementia worldwide, significant questions remain about the relationship between speaking more than one language and later cognitive decline. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We examined associations between cognitive reserve and late-life amyloid-β deposition using florbetapir positron emission tomography (PET). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
39/100
Brain age prediction is a machine learning method that estimates an individual's chronological age from their neuroimaging scans. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Three major neurobiological features shared by LLD and AD include neurodegeneration, disruption to cerebrovascular functioning, and increased levels of neuroinflammation. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This article covers current research on the relationship between depression and cognitive impairment in older adults. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Older adults with depression showed increased ReHo in the bilateral dorsal anterior cingulate cortex (dACC) and the right middle temporal gyrus, with no significant findings for network homogeneity. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Although cognitive and functional impairment are the hallmark features of Alzheimer's disease (AD), neuropsychiatric symptoms associated with AD account for increased rates of disability and profoundly impact the quality of life of both patients and their caregivers. 2 key findings →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
Dementia has become a major public health concern around the world. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Among cognitively normal individuals, a 5 μg/m3 increase in 7-day and 1-year average PM2.5 was associated with elevated VCAM-1 (7-day: 35.4 (9.7, 61.1) ng/ml; 1-year: 51.8 (6.5, 97.1) ng/ml). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
39/100
In these models, PM2.5 concentration was associated with smaller left hippocampal volume. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The third part of the DGP statement introduces the current body of knowledge on less studied health outcomes associated with exposure to ambient air pollution: the negative impact on metabolism leading to impaired glucose tolerance and diabetes as well as contribution to the development of neurodegenerative disorders and delayed cognitive function in children. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Social determinants of health, such as neighborhood disadvantage, have been linked to an increased risk of clinical dementia syndrome; however, their association with neuropathologically confirmed Alzheimer's disease (AD) remains unknown. 5 key findings →
Participants: 434 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
PM2.5 particles in air pollution have been widely considered associated with respiratory and cardiovascular diseases. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Exposure to ambient air pollution and noise is ubiquitous globally. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Airborne particulate matter poses a serious threat to human health. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
These innovations can be benchmarked on firm understanding of nutrigenomics and the personalized management of individuals at risk. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Traffic-related air pollution particulate matter (TRAP-PM) is associated with increased risk of Alzheimer Disease (AD). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Fewer than 5% of Alzheimer's disease (AD) cases are demonstrably directly inherited, indicating that environmental factors may be important in initiating and/or promoting the disease. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The effect of austerity and associated budgets are strong contenders,3Ruckert A Labonté R Health inequities in the age of austerity: the need for social protection policies. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
It has been reported that taurine intake in the past may have a positive effect on present cognitive function in the elderly. 4 key findings →
Design: cross-sectional Participants: 481 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 31,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 31,380 records, built mostly from automated pulls of Europe PMC (65.6% of the library) and OpenAlex (16.2%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,048 records (3.3% of the library) are not peer-reviewed — 973 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →
Newest studies, as a dated timeline → Atom feed Where this research is being discussed: events