31,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Among 2556 patients (mean age 79 ± 9 years; 56% women), delirium occurred in 957 (37%). 5 key findings →
Design: cohort study Participants: 2,556 Evidence: moderate
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Out of 929 patients, 184 (20%) experienced POD. 5 key findings →
Design: cohort study Participants: 929 Evidence: moderate
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Our sample included 11,105 patients (median age 77, 51% female), with 2299 in the hallway group and 8806 in the non-hallway group. 5 key findings →
Design: retrospective cohort Participants: 11,105 Evidence: moderate
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Of 689 participants, CI was associated with delirium (adjusted odds ratio [aOR]: 3.64, 95% CI: 1.31, 9.49, P-value = 0.009), 90-day complications (aOR: 2.26, 95% CI: 1.14, 4.28, P-value = 0.015), and 90-day composite adverse outcomes (aOR: 2.03, 95% CI: 1.03, 3.81, P-value = 0.033). 5 key findings →
Design: cohort study Participants: 689 Evidence: moderate
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First, based on pooled results of RCTs, the melatonin agonists melatonin and ramelteon were not found to reduce delirium incidence (RR 0.94, 95% CI 0.72–1.22, k = 16 studies; RR 0.63, 95% CI 0.39–1.03, k = 8, respectively). 5 key findings →
Design: systematic review Participants: 203 Evidence: high
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Across several cohorts, delirium is emerging as an important prognostic signal, independent of chronic markers of baseline morbidity, that identifies patients at markedly increased risk of death or future dementia. 5 key findings →
Design: cohort study Participants: 2,556 Evidence: moderate
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Dementia prevalence was 22%, with 35% undiagnosed. 4 key findings →
Design: prospective cohort Participants: 2,003 Evidence: moderate
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Among 2889 patients with delirium (mean age 85 years; 54.7% female), 59.8% were triaged at SETS 1–2 (high priority) and 40.2% at SETS 3–4 (low priority). 5 key findings →
Design: cohort study Participants: 2,889 Evidence: moderate
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Among 547 310 older adults undergoing surgery, 43 041 (7·9%) had preoperative dementia. 5 key findings →
Design: cohort study Evidence: moderate
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Of 574 older adults, 187 (33%) were admitted. 5 key findings →
Participants: 574 Evidence: low
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From the database searches, 4796 records were identified. 5 key findings →
Participants: 12 Evidence: high
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Cognitive decline is closely associated with biological aging and with interconnected processes, including chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and cellular senescence. 2 key findings →
Design: narrative review Evidence: high
Full summary, score breakdown and related studies → Original source
In a sample of 2,599 Medicare beneficiaries (mean age 78.4 years, 52.9% female, 81.8% White), we identified a total of 5,677 hospitalization claims. 5 key findings →
Participants: 5,677 Evidence: low
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A case-control GWAS was performed in the UK Biobank to identify genetic variants associated with postoperative delirium, adjusted for age, sex, genetic chip, and the first 10 principal components. 5 key findings →
Design: case-control study Evidence: moderate
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Over a median follow-up of 5.9-7.9 years, 3,492 dementia cases were identified. 5 key findings →
Participants: 44,488 Evidence: low
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Little is known about the relationships between infections, sepsis and dysphagia. 3 key findings →
Participants: 4,475 Evidence: low
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Among 45,651 patients, 311 delirium events occurred among continuous users and 84 among early discontinuers, corresponding to incidence rates of 66 and 112 events per 10,000 person-years, respectively. 5 key findings →
Participants: 45,651 Evidence: low
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DSD occurred in 680 patients (39.8%). Compared with dementia alone, DSD was associated with higher PAS scores (5.3 vs. 4.0, p < 0.001), poorer functional status (FIM 48.6 vs. 57.8, p < 0.001) and more frequent in-hospital falls (29.9% vs. 17.5%, p < 0.001). 5 key findings →
Participants: 1,709 Evidence: low
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AWVs were associated with reduced risks for falls (HR: 0.976 for 2 AWVs; 0.936 for ≥3 AWVs) and fractures (HR: 0.978 for 1 AWV; 0.960 for 2 AWVs; 0.927 for ≥3 AWVs), with greater reductions observed with more AVWs. 5 key findings →
Evidence: moderate
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Delirium is a common health problem with serious and long-lasting health consequences that disproportionately affects vulnerable population groups (especially older people with dementia or frailty). 3 key findings →
Evidence: low
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Of 4288 consultations with patients ≥65 years in the study periods, 402 (9.4%) involved possible or probable delirium. 5 key findings →
Evidence: low
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The resulting framework is organized around 3 themes-vision, process, and impact-each containing guiding questions that encourage dialogical reflection and decision-making. 4 key findings →
Evidence: low
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376 323 elective geriatric THA patient samples from the NIS database were included, with an overall dementia prevalence of 2.05%. 3 key findings →
Evidence: low
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Alzheimer's disease and related dementias (ADRD) affects millions of patients worldwide and is a leading cause of morbidity in older adults. 4 key findings →
Evidence: low
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Twenty-six participants (15 ED clinicians, 3 caregivers, 8 community advisors) contributed perspectives. 5 key findings →
Evidence: low
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Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 31,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 31,380 records, built mostly from automated pulls of Europe PMC (65.6% of the library) and OpenAlex (16.2%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,048 records (3.3% of the library) are not peer-reviewed — 973 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →
Newest studies, as a dated timeline → Atom feed Where this research is being discussed: events