This is the first study to investigate urine biomarker through exercise intervention. 3 key findings →
Participants: 12 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Research
27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Cognitive decline leading to dementia represents a global health burden. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Our findings suggest that the onset of dementia-related syndromes may be initiated by repetitive cerebral concussions in professional football players. 5 key findings →
Evidence: low
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Loss of cholinergic neurons is associated with impaired cognitive function, particularly memory loss and Alzheimer disease (AD). 3 key findings →
Participants: 1,391 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
AD is a public health epidemic, which seriously impacts cognition, mood and daily activities; however, one type of activity, exercise, has been shown to alter these states. 3 key findings →
Participants: 104 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Higher prevalence of SCD in SGM adults highlights the importance of ensuring inclusive screenings, interventions, care services, and resources for SGM adults. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
In multivariate analysis, feeding tube use was found to be associated with swallowing problems (odds ratio (OR) 5.4, 95% confidence interval (CI) 4.3-6.8); urban location of nursing home (OR 2.9, 95% CI 2.3-3.5); non-white race (OR 2.7, 95% CI 1.9-3.6); stroke (OR 2.5, 95% CI 2.0-3.1); and absence of dementia (OR 2.5, 95% CI 2.0-3.1). 5 key findings →
Design: cross-sectional Participants: 4,997 Evidence: low
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Causal pathways corresponding to all 4 hypotheses were supported. 2 key findings →
Design: longitudinal study Evidence: moderate
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51/100
Cognitive decline in older adults contributes to reduced ability to perform daily tasks and continued disuse leads to muscle weakness and potentiates functional loss. 1 key finding →
Design: longitudinal study Evidence: moderate
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A decline in physical and/or cognitive function is a common feature of aging, and frailty has been shown to be associated with cognitive impairment and dementia. 4 key findings →
Design: longitudinal study Evidence: moderate
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Whether deficits in specific cognitive domains are associated with long-term survival in patients with ischaemic stroke is not known in detail. 3 key findings →
Participants: 409 Evidence: low
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Functional decline is associated with risk and can be efficiently assessed by participants and study partners (SPs). 4 key findings →
Design: longitudinal study Evidence: moderate
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The prevalence of cognitive impairment, MCI, and dementia among participants aged 60 years and older were 21.48% (95% CI, 19.90-23.10), 15.70% (95% CI, 14.30-17.10), and 5.77 (95% CI, 4.90-6.70), respectively. 5 key findings →
Design: cross-sectional Participants: 3,233 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Among 5,145 participants included in the analyses, 747 (14.5 %) reported hearing loss, including 207 Black adults and 199 White adults. 5 key findings →
Design: cohort study Participants: 5,145 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
These lessons emphasize the importance of ensuring tests are feasible across both high-income countries and LMICs, maintaining consistency within studies and over time, and designing comprehensive cognitive batteries for improved measurement precision of general and domain-specific phenotypes. 4 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
This study aims to identify depressive risks in elderly individuals with subjective cognitive decline (SCD) and develop a predictive model using machine learning algorithms to enable timely interventions. 3 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Our findings highlight the altered phases of swallowing in patients with dementia. 4 key findings →
Design: cross-sectional Participants: 158 Evidence: low
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General and central obesity trajectories beyond midlife with persistently high or increasing patterns were significantly associated with an increased risk of developing cognitive decline and dementia in late life. 3 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Cognitive training produced a significant, moderate improvement in cognitive task performance (Hedges’ g = 0.451, 95% CI 0.207–0.696; p < .001). 5 key findings →
Design: meta-analysis Evidence: high
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Sarcopenia and its components were associated with baseline MMSE and MMSE changes. 5 key findings →
Design: cohort study Participants: 3,146 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
This olive oil-cognition association needs to be confirmed by further studies. 3 key findings →
Participants: 6,947 Evidence: low
Full summary, score breakdown and related studies → Original source
Multiple factors affect cognitive health, such as age-related changes in the brain, injuries, mood disorders, substance abuse, and diseases. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
A primary goal of research in cognitive impairment and dementia is to understand how some individuals retain sufficient cognitive function for a fulfilling life while many others are robbed of their independence, sometimes their essence, in the last years and decades of life. 5 key findings →
Evidence: low
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The incidence of dementia and cardiovascular disease (CVD) increases with age. 5 key findings →
Evidence: low
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Impaired everyday function is a diagnostic criterion for dementia, and a determinant of healthcare utilization and caregiver burden. 3 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
From across this tag
10 of the 1,130 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Cognitive improvement effects of electro-acupuncture for the treatment of MCI compared with Western medications: a systematic review and Meta-analysis
- A Critical Review of the Study of Neuroprotective Diets to Reduce Cognitive Decline
- Age- and education-adjusted normative data for the Montreal Cognitive Assessment (MoCA) in older adults age 70-99
- Relationship between chewing ability and cognitive impairment in the rural elderly
- Association of neighborhood disadvantage with cognitive function and cortical disorganization in an unimpaired cohort
- The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment: A Pilot Feasibility Study
- Harmonized Cognitive Assessment Protocol: What makes an HCAP an HCAP? An adaptive architecture for measuring cognitive aging around the world
- Effect of Area-Level Socioeconomic Deprivation on Risk of Cognitive Dysfunction in Older Adults
- Cross-sectional and longitudinal associations between adherence to Mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis
- Dietary patterns: a novel approach to examine the link between nutrition and cognitive function in older individuals
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →