27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Cerebral small vessel disease (SVD) is frequently comorbid with Alzheimer's disease (AD), and brain endothelial cells (BECs) express genes associated with AD genetic risk. 4 key findings →
Evidence: low
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In this study, we show that repeated ethanol binges aggravate the amyloid pathology and plaque burden in the hippocampus of APP/PS1 mice. 5 key findings →
Evidence: low
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SnRNA-seq analysis revealed elevated microglial proportions across all dementia subtypes compared to NCI. 5 key findings →
Evidence: low
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Thirteen differentially expressed CSF proteins in A+T+ individuals correlated positively with tryptophan metabolites and pyroglutamate, and negatively with regulatory T cells, isobutyrate, and dendritic cells. 4 key findings →
Participants: 19 Evidence: low
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The 4R-like pattern was more prevalent and more strongly expressed (84.3%, mean score, 2.0 ± 1.1) in patients with a consensus diagnosis of PSP/CBD (joint diagnostic group of clinically likely 4R tauopathies) than in all other groups (11.6%, 0.26 ± 0.75, P < 0.0001). 5 key findings →
Evidence: moderate
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The study population demonstrated limited PET-based amyloid-β and tau pathology, which did not associate with any of the investigated plasma biomarkers. 5 key findings →
Design: cross-sectional Participants: 49 Evidence: low
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Using the RGC marker ribonucleic acid binding protein with multiple splicing (RBPMS) and Nissl staining, we found a 46–56% reduction in RBPMS + RGCs and Nissl + neurons in the ganglion cell layer (GCL) of MCI and AD retinas ( P < 0.05–0.001). 5 key findings →
Evidence: low
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Alzheimer's disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles. 2 key findings →
Evidence: low
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CSF and plasma SNAP25 were positively correlated, but no correlation was observed for VAMP2 in these matrices. 5 key findings →
Participants: 80 Evidence: low
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Aggregation of microtubule-associated tau protein is a distinct hallmark of several neurodegenerative disorders such as Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and progressive supranuclear palsy (PSP). 2 key findings →
Evidence: low
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Neurodegenerative diseases are characterized by protein aggregation and overlapping pathologies, challenging traditional classifications and highlighting shared underlying mechanisms. 1 key finding →
Evidence: low
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Alzheimer's disease is a neurodegenerative disorder characterized by two hallmarks: amyloid beta plaques and neurofibrillary tangles. 2 key findings →
Participants: 708,580 Evidence: low
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These findings suggest that subcortical VCIND modifies the relationship between FPN lateralization and cognitive functions, rather than altering the lateralization pattern itself. 1 key finding →
Participants: 30 Evidence: high
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When systematically reviewed using the USDA Nutrition Evidence Systematic Review method and an a priori established protocol, a common theme emerged: diets characterized by higher consumption of vegetables, fruits, legumes, nuts, fish, seafood, and unsaturated vegetable oils, alongside lower intake of red and processed meats and sugar-sweetened beverages, are consistently associated with a reduced risk of cognitive decline and dementia. 2 key findings →
Design: systematic review Evidence: high
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Participating ICU in both surveys (2016: n = 559, 2024: n = 447) had similar basic characteristics and enabled comparison. 5 key findings →
Participants: 559 Evidence: low
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The studied cohort comprised 4601 patients, mean age of 83.93 years and 56.26% were women. 5 key findings →
Participants: 4,601 Evidence: moderate
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The risk of delirium admissions was elevated for the first 1-30 days of prescriptions [IRR 1.54 (95% CI 1.30-1.82) for men, 1.44 (1.22-1.70) for women] and whilst reducing over time for women [1.10 (0.94-1.29) for 91-365 days of prescriptions], it remained elevated for men [1.38 (1.17-1.64)]. 5 key findings →
Participants: 293 Evidence: low
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The incidence of POD was 8.2% (26 of 316). 5 key findings →
Participants: 316 Evidence: low
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NPs reported that the quality of dementia care in their practices is poorer than the overall care provided. 5 key findings →
Design: cross-sectional Evidence: low
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Among 51,202 admissions (mean/SD age = 82/7 years), any cognitive morbidity was present in 18,225 (35.6%, 95% CI 35.2-36.0%): delirium occurred in 24.0% (n = 12,289, of which 14.3% (n = 7332) had delirium only and 9.7% (n = 4957) had delirium + dementia) dementia only in 8.7%, (n = 4450), AMTS <8 in 2.9% (n = 1486). 5 key findings →
Participants: 12,289 Evidence: low
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We included 150 patients; 67.3% met criteria for PC need. 4 key findings →
Design: cross-sectional Participants: 150 Evidence: low
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Of 9872 individuals, 3563 (36%) died within 6 months. 5 key findings →
Participants: 9,872 Evidence: low
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Of the 127 participants, one-third died during their stay. 5 key findings →
Participants: 127 Evidence: low
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We have enrolled 29 clinicians and 53 FCPs and aim to have 24 clinicians matched with 96 FCPs (N = 120) to complete the intervention. 3 key findings →
Participants: 120 Evidence: high
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Pre-post evaluations revealed significant reductions in physical symptoms, psychosocial-spiritual distresses and information insufficiency of patients in the first three months of service. 4 key findings →
Participants: 567 Evidence: high
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Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled.
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →