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45/100

✓ Peer-reviewed alzhub usefulness score 45 out of 100. Prevention trials

Topic: Brain proteins, microglia and lab models

Abstract Vascular cognitive impairment no dementia (VCIND) represents cognitive deficits due to vascular causes, without meeting the criteria for dementia. Cognitive training has emerged as a safe and effective intervention for VCIND, though its underlying mechanisms remain obscure. This study investigates how subcortical VCIND and computerized cognitive training affect brain functional lateralization of the fronto-parietal network (FPN), whose functions are notably influenced by both VCIND and cognitive training. In a randomized, active-controlled design for VCIND patients, we assessed the resting-state functional lateralization index (LI) of the FPN and conducted neuropsychological assessments in VCIND training and control groups (n = 30 per group) at baseline, after a 7-week intervention and at a 6-month follow-up. A healthy older group (n = 30) only provided baseline data. At baseline, VCIND patients showed an FPN lateralization pattern similar to that of healthy older adults. However, a stronger right-lateralized interhemispheric heterotopic LI in FPN correlated with better memory performance only in healthy adults. After the intervention, only the VCIND training group exhibited reduced lateralization in FPN, shifting to a bilateral interhemispheric LI, with stronger leftward changes correlating with improved executive and memory functions. Notably, these changes disappeared at the 6-month follow-up. These findings suggest that subcortical VCIND modifies the relationship between FPN lateralization and cognitive functions, rather than altering the lateralization pattern itself. Short-term computerized cognitive training facilitates executive and memory functions by promoting hemispherical reorganizing of FPN and functional compensation, although the benefits may diminish over time.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Jin, X., Xing, Y., Lyu, B., Ding, J., Wang, X., Du, Y., et al. (2025). Cognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment. Brain Communications. https://doi.org/10.1093/braincomms/fcaf394

Vancouver

Jin X, Xing Y, Lyu B, Ding J, Wang X, Du Y, et al. Cognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment. Brain Communications. 2025. doi:10.1093/braincomms/fcaf394. PMID: 41234528.

BibTeX

@article{jin2025-41234528,
  author  = {Jin, Xinhu and Xing, Yi and Lyu, Baihan and Ding, Junhua and Wang, Xiuyi and Du, Yi and Tang, Yi},
  title   = {{Cognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf394},
  pmid    = {41234528},
  url     = {https://doi.org/10.1093/braincomms/fcaf394}
}

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Key findings

These findings suggest that subcortical VCIND modifies the relationship between FPN lateralization and cognitive functions, rather than altering the lateralization pattern itself.

Why it matters

In this randomized study of 60 patients with vascular cognitive impairment no dementia, cognitive training shifted brain network lateralization toward a more bilateral pattern, and these changes correlated with improved executive and memory functions. The findings suggest cognitive training reorganizes brain networks, though the changes disappeared by follow-up.

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Study details

Participants30
Evidence strengthHigh

How this study scored 45/100

Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Brain Communications)
Journal's citation record	0 / 4	Brain Communications: journal h-index 67 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	30 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Yi Tang: h-index 35 (OpenAlex, whole career)
Institution's track record	2 / 3	Chinese Academy of Sciences: institution h-index 1,801 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 8 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41234528)
Free to read	2 / 2	Free to read
Total	45 / 100	—

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