28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
A larger WHR may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia. 3 key findings →
Design: cohort study Participants: 112 Evidence: moderate
Full summary, score breakdown and related studies → Original source
We investigated in a population-based cohort study the association of global and lobar brain tissue volumes with specific cognitive domains and risk of dementia. 3 key findings →
Design: cohort study Participants: 490 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Consumption of up to three servings of wine daily is associated with a lower risk of AD in elderly individuals without the APOE epsilon-4 allele. 5 key findings →
Design: cohort study Participants: 260 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Elevated midlife blood pressures, and the resulting increased white matter hyperintensities, increase the risk for MCI in a group of community-dwelling older men to at least the same degree as apolipoprotein E4 genotype. 5 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source
We conclude that smaller PFAv may contribute to slower gait through slower information processing. 4 key findings →
Design: longitudinal study Participants: 214 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Hyperhomocysteinemia is associated with an increased risk of vascular disease, and recent results suggest that it also could increase the risk of dementia. 4 key findings →
Design: cross-sectional Participants: 1,241 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Among 251 patients examined 3 months after the onset of acute ischemic stroke, we diagnosed dementia in 66 (26.3%) by using modified DSM-III-R criteria based on neuropsychological, neurological, functional, and psychiatric examinations. 4 key findings →
Design: cross-sectional Participants: 251 Evidence: low
Full summary, score breakdown and related studies → Original source
In univariate analysis, all 29 adiposity and metabolic measures assessed were associated with ' g ' at P < 0.05. 5 key findings →
Participants: 8,769 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Use of metformin, DPP4 inhibitors, GLP1 analogs and SGLT2 inhibitors was associated with lower risk of dementia in patients with diabetes. 3 key findings →
Design: case-control study Participants: 250 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Lower RBC DHA levels are associated with smaller brain volumes and a "vascular" pattern of cognitive impairment even in persons free of clinical dementia. 3 key findings →
Design: cross-sectional Participants: 1,575 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Sensory impairments are associated with greater risk of dementia in Chinese older adults. 4 key findings →
Design: cross-sectional Participants: 250,752 Evidence: low
Full summary, score breakdown and related studies → Original source
Depression symptoms before the onset of AD are associated with the development of AD, even in families where first depression symptoms occurred more than 25 years before the onset of AD. 4 key findings →
Design: case-control study Participants: 1,953 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Long-term exposure to the highest tertile of PM10 or ozone was significantly associated with an increased risk of AD and VaD. 2 key findings →
Design: case-control study Evidence: moderate
Full summary, score breakdown and related studies → Original source
An increased incidence of mild cognitive impairment was observed in community-dwelling elderly adults who had nonpsychotic psychiatric symptoms at baseline. 3 key findings →
Design: cohort study Participants: 365 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Cerebrovascular risk factors are associated with Parkinson disease, an effect comparable to their association with Alzheimer disease. 5 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Increasing frailty is associated with incident AD and the rate of cognitive decline in older persons. 5 key findings →
Design: longitudinal study Participants: 823 Evidence: moderate
Full summary, score breakdown and related studies → Original source
ACAD's traction indicates the feasibility of recruiting Asians for clinical research to enhance understanding of AD risk factors. 1 key finding →
Participants: 606 Evidence: moderate
Full summary, score breakdown and related studies → Original source
These findings suggest that promoting CVH in older adults may help alleviate the burden of neurodegenerative diseases, particularly among Black adults, who are known to experience a higher prevalence of cardiovascular disease. 5 key findings →
Design: cohort study Participants: 1,018 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Low plasma levels of apoE are associated with increased risk of future Alzheimer disease and all dementia in the general population, independent of ε2/ε3/ε4 APOE genotype. 3 key findings →
Participants: 75,708 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Individuals with AD and VaD have higher Hct levels than controls; however, a causal relationship between high-Hct level and risk of developing dementia is not supported. 5 key findings →
Design: meta-analysis Participants: 6,122 Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
However, the effect sizes were small. 1 key finding →
Participants: 34 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
HI is associated with increased risk of developing dementia in older adults. 3 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Only 11 putative risk factors for delirium are supported by either strong or moderate level of evidence. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Lipid-lowering agent use was associated with a lower risk of dementia, and specifically of Alzheimer disease, in those younger than 80 years. 5 key findings →
Design: cohort study Participants: 492 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Delirium and dementia are two frequent causes of cognitive impairment among older adults and have a distinct, complex and interconnected relationship. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
10 of the 3,281 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →